DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31792 and abcc1

DIOPT Version :9

Sequence 1:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster
Sequence 2:	XP_001341895.3	Gene:	abcc1 / 100002010	ZFINID:	ZDB-GENE-050517-15	Length:	1518	Species:	Danio rerio

Alignment Length:	1383	Identity:	470/1383 - (33%)
Similarity:	726/1383 - (52%)	Gaps:	174/1383 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSWANE--------- 68
            |...::..|.::||:.....:||.|..|..|||:....|.::|.:..:|...|..|
Zfish   209 PESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRPVD 273

  Fly    69 --LETNKKNA---------------------------SLLRVLFRVFGRYFVFLGLVLFCLEVIL 104
              |.:.|::.                           ||...|.|.||.||:...|.....:|::
Zfish   274 KTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDVLM 338

  Fly   105 TVQPMFLMKLISSFSNPS--PTSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSS 167
            .|.|. :::|:..|.|.|  ||.:|  |.|...:.:.:.|:.:::..|.......|:::|..:..
Zfish   339 FVGPE-ILRLLILFVNDSSAPTWHG--YFYTALLFVCTCLQTLILQKYFHVCFVTGMRLRTAIVG 400

  Fly   168 MIYRKCLRLTKTDLGEISTGHIINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAA 232
            .:|||.|.:|.......:.|.|:||:|.|..|....|.:.:.:|.||||.::..|.::|.:|.:.
Zfish   401 AVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGASV 465

  Fly   233 VFGMTFILLFIPLQMYLGKKISGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHA 297
            :.|:..::|.:||...:..|....::......|.|:::|.|::.||:|:|:|||||.|:..|:..
Zfish   466 LAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAI 530

  Fly   298 RHKEINSIRHVAYAKCL---IWSFNRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVR-- 357
            |..|:..::.:||...:   .|....||..:|.|...| .|.....|.|:.||:..|.:|::|
Zfish   531 RESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYV-LVDENNILDAQKAFVSLALFNILRFP 594

  Fly   358 TNMTAYFSVGVTQTAETLVSIKRVQKLLLSGEVVAKDENVVSNGAEEDLQEAREKLLVTPTPMRA 422
            .||   ..:.::...:..||::|::..|...|:  .|:||             |:..::.||
Zfish   595 LNM---LPMVISSMVQASVSMQRLRVFLSHEEL--DDDNV-------------ERPAISGTP--- 638

  Fly   423 PEKPPHNSEDCVSISELKAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELR 487
                     |.:.|::....|:.:.|. ||..:|:.:..|||||:|||.|||||||:.|:|||:.
Zfish   639 ---------DSIRIADGAFSWSKDDPP-TLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMH 693

  Fly   488 VESGEIEVTGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTIL 552
            .:.|.:.:.||::|..|:.|:.:.|::.|||||:......|..||..|||..|.|:||..|.|.:
Zfish   694 KQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEI 758

  Fly   553 GDRGASLSGGQKARISLARSVYRDASIYLLDDPLSAVDSSVARRLFEECL--RGHLRDKIVILVT 615
            |::|.:||||||.|:|:||:||.:.|:|||||||||||:.|.:.:||:.:  :|.|:.:..:|||
Zfish   759 GEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVT 823

  Fly   616 HQLQFLQQADQIVIMEMGKVKAVGTY------------------------------ESLHKSGLD 650
            |.|.||.|||.|::|..|::..:|:|                              :::.:.||:
Zfish   824 HGLSFLPQADLILVMVDGEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEESLGDAVPRKGLE 888

  Fly   651 FGIVLDDP----------VNDNEAAEDRSRTSSITDQRRSSVKSVLSHAESCPEDVGEEQKINLQ 705
            .|    .|          :|...|.:...:|.:..|...:..||    ||:  ..:.|..|.|
Zfish   889 NG----GPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKS----AEA--SRLTEADKAN-- 941

  Fly   706 RQQLGRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLG-DYFLSPWVSRNEKMVAHNYTTD 769
               .||..|.|:.:|.:|.|..||...:..|| |.. |:||| :|:||.|.  ::.:|  |.|..
Zfish   942 ---TGRVKLSVFWEYMKAIGLPLSIFSIFLFF-CHH-LSSLGSNYWLSLWT--DDPVV--NNTQP 997

  Fly   770 AKDADFEMHAAY-IYMLITVLSIMVTIKRSFLFFNLAMRASIQLHNSMFRGISRASMYFFNKNPA 833
            .::....::.|. |...|.|....|::...      .:.||..||.:|...:.|:.|.||.:.|:
Zfish   998 KREMRLGVYGALGISQGIAVFCYSVSVSVG------GILASRYLHQTMLYNVLRSPMSFFERTPS 1056

  Fly   834 GSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPL--FLIPALAFGIVIYYLRSF 896
            |:::|||:|:...:|.::|:||...:.......|:..||.|..||  .:||.|  |::.::::.|
Zfish  1057 GNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPL--GLLYFFVQRF 1119

  Fly   897 YLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDGYQDMHSSASYMFISTSR 961
            |:.:|..:||||:.:|||||:||..:|.|.|.|||||.......|.||..|.:..|.:..|..:|
Zfish  1120 YVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANR 1184

  Fly   962 AFAYWMDI-------FCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQWTVRQSAELEN 1019
            ..|..::.       |..||..|...:.      |...:||:|:.|:.:|.::.|.||.|:|||.
Zfish  1185 WLAVRLEFVGNCIVTFAALFAVMARNNL------SPGIMGLSISYALQVTASLNWLVRMSSELET 1243

  Fly  1020 TMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSESVLKSLSFVIK 1084
            .:::|||:.||.:.|.|...:......| ..||..|.||..:..|||...|  |..:..:|..|.
Zfish  1244 NIVAVERVKEYGDTEKEAEWKLENSNLP-PGWPTAGHIEIHKFGLRYREDL--ELAICDISVNIA 1305

  Fly  1085 PKEKVGIVGRTGAGKSSLINALFR-LSYNDGSVRIDDKDTNDMGLHDLRSKISIIPQEPVLFSGT 1148
            ..||||||||||||||||...||| :...:|.:|||..:..|:|||:|||:|:||||:||||||:
Zfish  1306 GGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGS 1370

  Fly  1149 VRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVCLARAILRDN 1213
            :|.||||||.|:|:.:|.:||...||..|:.:...|..:.:|||.|.|:|||||||||||:||..
Zfish  1371 LRMNLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKT 1435

  Fly  1214 RILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGRVVEFGTPYE 1278
            :|||:|||||.||.:||.|||:|||.:|.:|||||:||||:||||..||||:|.|::.||.:|..
Zfish  1436 KILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSN 1500

  Fly  1279 LLTADDTNAFQDLVKQTG 1296
            |:.  ....|..:.|.:|
Zfish  1501 LIA--KKGIFYKMAKDSG 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	467/1366 (34%)
		ABC_membrane	94..360	CDD:294371	76/272 (28%)
		ABCC_MRP_domain1	434..634	CDD:213217	92/201 (46%)
		ABC_membrane	736..980	CDD:294371	82/254 (32%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	125/221 (57%)
abcc1	XP_001341895.3	MRP_assoc_pro	7..1517	CDD:188098	470/1383 (34%)
		ABC_membrane	331..595	CDD:279056	75/267 (28%)
		ABCC_MRP_domain1	641..842	CDD:213217	92/201 (46%)
		ABC_membrane	966..1231	CDD:279056	88/284 (31%)
		ABCC_MRP_domain2	1278..1498	CDD:213211	125/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760