DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10431 and THAP2

DIOPT Version :9

Sequence 1:	NP_001286078.1	Gene:	CG10431 / 35157	FlyBaseID:	FBgn0032730	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_113623.1	Gene:	THAP2 / 83591	HGNCID:	20854	Length:	228	Species:	Homo sapiens

Alignment Length:	192	Identity:	52/192 - (27%)
Similarity:	80/192 - (41%)	Gaps:	49/192 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAHCAVINCSHKYVHAGSISFHRFPF--KRKDLLQKWKEFTQRSAQWMPSKWSALCSRHFGDED 63
            ||.:||...|:..|....:|||||||.  ||:   ::|....:|. .::|.|.:.|||:||....
Human     1 MPTNCAAAGCATTYNKHINISFHRFPLDPKRR---KEWVRLVRRK-NFVPGKHTFLCSKHFEASC 61

  Fly    64 FNCSNNRKTLKKNAVPSIRVSEDDSMSGHLEQVSPSNRPTHKQTLSSAAESAATGVKATCRFCGS 128
            |:.:...:.||.:|||:|     .....|::.:...:|...|:. :|.:.:..:.:|:
Human    62 FDLTGQTRRLKMDAVPTI-----FDFCTHIKSMKLKSRNLLKKN-NSCSPAGPSNLKS------- 113

  Fly   129 SAINCSS----------FDKSFELFGMIQKCFPTLQILQDDTLPKEIC-----QECCLQLER 175
               |.||          |....|....|.|            |.|||.     .:.|||.||
Human   114 ---NISSQQVLLEHSYAFRNPMEAKKRIIK------------LEKEIASLRRKMKTCLQKER 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10431	NP_001286078.1	THAP	4..81	CDD:283206	28/78 (36%)
		zf-AD	123..192	CDD:214871	16/68 (24%)
		zf-C2H2_6	674..700	CDD:290623
		C2H2 Zn finger	677..697	CDD:275368
		C2H2 Zn finger	705..726	CDD:275368
THAP2	NP_113623.1	THAP	5..80	CDD:310232	29/83 (35%)
THAP2	NP_113623.1	HCFC1-binding motif (HBM). /evidence=ECO:0000250	123..126		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I10030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001174
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910