DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10431 and ZFX

DIOPT Version :9

Sequence 1:	NP_001286078.1	Gene:	CG10431 / 35157	FlyBaseID:	FBgn0032730	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_001317256.1	Gene:	ZFX / 7543	HGNCID:	12869	Length:	844	Species:	Homo sapiens

Alignment Length:	377	Identity:	75/377 - (19%)
Similarity:	132/377 - (35%)	Gaps:	95/377 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 VVESSAAFRLHNCTLCTAKFITIDSLNQHYAHSHSNSTPMVSVPPMNICLPSLTMNPPMKMESNR 462
            |.:...|.::|.|..|..:......||:|....||.:.|       :||           :|..:
Human   548 VHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFP-------HIC-----------VECGK 594

  Fly   463 GLVATEQSEYWPLEWHNSPVSKQPRKKIDILDMQSSFLHHKDLIPTATQLSAPAPDPQLVAVTAS 527
            |.            .|.|.:.|..|........|..:..::         ||.:.:.: ..|...
Human   595 GF------------RHPSELKKHMRIHTGEKPYQCQYCEYR---------SADSSNLK-THVKTK 637

  Fly   528 YAKLANRYRKLQLKC----------KKLKSPRKVHR--KTYVCRMCRKGFSKFKNLHHHRRQKAH 580
            ::|      ::..||          |:::....:|:  ||:.|..|....|...:|      |.|
Human   638 HSK------EMPFKCDICLLTFSDTKEVQQHALIHQESKTHQCLHCDHKSSNSSDL------KRH 690

  Fly   581 FVKL-IPNFSGRCSGCLKFFRSRLGLRQHMRYICQSLSLKNHRRLQSFKCRHCQAIAFAHWRLYR 644
            .:.: ..::..:|..|.|.|.....|::|         :..|:..:..:||||. ...|...:..
Human   691 IISVHTKDYPHKCDMCDKGFHRPSELKKH---------VAAHKGKKMHQCRHCD-FKIADPFVLS 745

  Fly   645 RHELNCRPKKSKTKVQTAMNSKKKVTPTQVFECNICKKSFGSLNGLRQHNITHSTERQHKCGICE 709
            ||.|:...|...                  |.|..|:|.|...:.|::|..|||..:.::|..||
Human   746 RHILSVHTKDLP------------------FRCKRCRKGFRQQSELKKHMKTHSGRKVYQCEYCE 792

  Fly   710 RVFKRRNGLSQHIKGYHLQLKPHECPVCQHRYALKCDMLRCRHSLRKGPAAG 761
            ......:|..:|:...|.:..||.|..|:..:....:  :.:|.:|.....|
Human   793 YSTTDASGFKRHVISIHTKDYPHRCEYCKKGFRRPSE--KNQHIMRHHKEVG 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10431	NP_001286078.1	THAP	4..81	CDD:283206
		zf-AD	123..192	CDD:214871
		zf-C2H2_6	674..700	CDD:290623	10/25 (40%)
		C2H2 Zn finger	677..697	CDD:275368	6/19 (32%)
		C2H2 Zn finger	705..726	CDD:275368	5/20 (25%)
ZFX	NP_001317256.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100