DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10431 and prdm15

DIOPT Version :9

Sequence 1:	NP_001286078.1	Gene:	CG10431 / 35157	FlyBaseID:	FBgn0032730	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	XP_009303772.1	Gene:	prdm15 / 566512	ZFINID:	ZDB-GENE-080618-4	Length:	1120	Species:	Danio rerio

Alignment Length:	677	Identity:	138/677 - (20%)
Similarity:	228/677 - (33%)	Gaps:	242/677 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 PKEI--CQECCLQLERFSQFID--------VVMLAQSELQRKYRRQLKIKQEPLVRVKQEACESL 216
            |.|.  |::|       .|:.|        ||.:..|.:..:.|..|....|  :|:.:|..|.:
Zfish     6 PDEFIWCEDC-------GQYHDSECPELGPVVTVRDSFVLSRARSSLPDSLE--IRLAEEGKEGV 61

  Fly   217 -------------------------DNLFPDELDMGLEQDDG---CDQEETEQKFQFCEFPMLNA 253
                                     :..||    :.:.|.||   |             |...|.
Zfish    62 FVLRRLVRRTRFGPFEATRTSSLQTEGAFP----LKIFQKDGSVVC-------------FDTSNE 109

  Fly   254 QDIINNCDIMEII---------NL------DDPFINIPDDADVGQSERLQPGRTANEMLQNELLT 303
            .|    |:.|.::         ||      ||.:.|...|...|...|:..|..
Zfish   110 DD----CNWMMLVRPATDHKHQNLTAYQQDDDVYFNTSQDVLPGTELRVWYGAF----------- 159

  Fly   304 EEHNYAKEEWQLPPHQYKTEKVEGTDAAPDAAPPPADPPPLQDNIDPPSAPEPRSCKPIVTNVSQ 368
                |||             |::.....|...||..:.|..:....|..||.|.:.        .
Zfish   160 ----YAK-------------KMDRPVLRPPLLPPQPELPSNKPGDSPMKAPPPENL--------P 199

  Fly   369 IPNPMICELLPQPA--PPTSIKPNIVVLNDSVVESSAAFRLHNCTLCTAKFITIDSLNQHYAHSH 431
            :|:.::|: .|.||  ||.   |.:.                            ::|:|
Zfish   200 VPDQLLCQ-TPAPAEDPPV---PQVT----------------------------EALSQ------ 226

  Fly   432 SNSTPMVS-VPPMNICLPSLTMNPPMKMESNRGL---VATEQSEYWPLEWHNSPVSK-QPRKKID 491
             |:|.::: :.|.    |:...:.|.:.::.:.:   .|....|....|.:..|:|. .|...:.
Zfish   227 -NNTAIIAPIQPE----PAKKQSRPRRTKTQKSVPSGAANSAQEAPVAESNEQPLSTVAPDVPLS 286

  Fly   492 ILDMQSSFLHHKDLIPTATQLSAPAPDPQLVAVTASYAKLANRYRKLQLKCKKLKSPRKVHRKTY 556
            :||:|...: ..|.:|..|.....:|        .|..|...|.|.|:        |...|::.|
Zfish   287 VLDVQEVMV-SVDPLPLKTSRLTRSP--------ISSGKPILRKRTLR--------PGGDHKRVY 334

  Fly   557 VCRMCRKGFSKFKNLHHHRRQKAHFVKLIPNFSGRCSGCLKFFRSRLGLRQHMRYICQSLSLKNH 621
            .|.:|.|.|....||:.|.|  :|..|..     :|..|.|.|..:..|:||:.|    ...||.
Zfish   335 QCCLCNKVFQNSSNLNRHIR--SHGDKCF-----KCDECDKMFSRKESLKQHISY----KHSKNE 388

  Fly   622 RRLQ-SFKCRHCQAIAFAHWRLYRRHELNCRPKKSKTKVQTAMNSKKKVTPTQVFECNICKKSFG 685
            ..:: .:||..|:. :|......|.|  |||                  |..:.|:|.||.:.|.
Zfish   389 PDIEYRYKCSTCEK-SFRVENALRFH--NCR------------------TDDKTFQCEICSRFFS 432

  Fly   686 SLNGLRQHNITHSTERQHKCGICERVFKRRNGLSQH----------IKGYHLQL----------K 730
            :.:.|.:|...|. |:.:.|.||.::|.|::.:..|          :|...|::          :
Zfish   433 TNSNLSKHKKKHG-EKLYACEICNKMFYRKDVMQDHQRRHVVGPKNLKREELEVNGEEGSKYRKE 496

  Fly   731 PHECPVCQHRYALKCDMLRCRHSLRKG 757
            |..||:|...::.:.:|  .:|.|..|
Zfish   497 PSACPICGKVFSCRSNM--NKHLLTHG 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10431	NP_001286078.1	THAP	4..81	CDD:283206
		zf-AD	123..192	CDD:214871	9/39 (23%)
		zf-C2H2_6	674..700	CDD:290623	8/25 (32%)
		C2H2 Zn finger	677..697	CDD:275368	6/19 (32%)
		C2H2 Zn finger	705..726	CDD:275368	7/30 (23%)
prdm15	XP_009303772.1	COG5048	312..807	CDD:227381	63/253 (25%)
		zf-C2H2	334..356	CDD:278523	9/23 (39%)
		C2H2 Zn finger	336..356	CDD:275368	8/21 (38%)
		C2H2 Zn finger	363..413	CDD:275368	15/54 (28%)
		zf-C2H2	422..444	CDD:278523	7/21 (33%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	500..520	CDD:275368	6/21 (29%)
		C2H2 Zn finger	527..547	CDD:275368
		C2H2 Zn finger	621..644	CDD:275368
		C2H2 Zn finger	657..677	CDD:275368
		zf-H2C2_2	669..694	CDD:290200
		C2H2 Zn finger	685..705	CDD:275368
		C2H2 Zn finger	713..733	CDD:275368
		C2H2 Zn finger	741..761	CDD:275368
		C2H2 Zn finger	769..789	CDD:275368
		C2H2 Zn finger	797..818	CDD:275368
		C2H2 Zn finger	826..844	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100