DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10431 and THAP1

DIOPT Version :9

Sequence 1:	NP_001286078.1	Gene:	CG10431 / 35157	FlyBaseID:	FBgn0032730	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	NP_060575.1	Gene:	THAP1 / 55145	HGNCID:	20856	Length:	213	Species:	Homo sapiens

Alignment Length:	219	Identity:	53/219 - (24%)
Similarity:	99/219 - (45%)	Gaps:	38/219 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAHCAVINCSHKYVHAGSISFHRFPFKRKDLLQKWKEFTQRSAQWMPSKWSALCSRHFGDEDFN 65
            |...|:...|.::|.....:|||:||..|..|.::| |...|...:.|:|:|::||.||..:.|.
Human     1 MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKEW-EAAVRRKNFKPTKYSSICSEHFTPDCFK 64

  Fly    66 CSNNRKTLKKNAVPSIRV------SEDDSMSGHLEQVSPSNRPTHKQTLSSAAESAATGVKATCR 124
            ...|.|.||:||||:|.:      .::|.:... ||:.|...|.....:.:|.......::
Human    65 RECNNKLLKENAVPTIFLCTEPHDKKEDLLEPQ-EQLPPPPLPPPVSQVDAAIGLLMPPLQ---- 124

  Fly   125 FCGSSAINCSSF-DKSFELFGMIQKCFPTLQILQDDTL-PKEICQECCLQLERFSQFIDVVMLAQ 187
                :.:|.|.| |.::.:               :||: .::...:...|:|:..:.:..   ||
Human   125 ----TPVNLSVFCDHNYTV---------------EDTMHQRKRIHQLEQQVEKLRKKLKT---AQ 167

  Fly   188 SELQRKYRRQLKIKQEPLVRVKQE 211
            ...:|:.|:..|:|:  :|..::|
Human   168 QRCRRQERQLEKLKE--VVHFQKE 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10431	NP_001286078.1	THAP	4..81	CDD:283206	29/76 (38%)
		zf-AD	123..192	CDD:214871	10/70 (14%)
		zf-C2H2_6	674..700	CDD:290623
		C2H2 Zn finger	677..697	CDD:275368
		C2H2 Zn finger	705..726	CDD:275368
THAP1	NP_060575.1	THAP	5..81	CDD:368467	29/76 (38%)
		HCFC1-binding motif (HBM)	134..137		1/2 (50%)
		Involved in homodimer formation. /evidence=ECO:0000269\|PubMed:28299530	139..185		10/65 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I10030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001174
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910