DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10431 and Zfx

DIOPT Version :9

Sequence 1:	NP_001286078.1	Gene:	CG10431 / 35157	FlyBaseID:	FBgn0032730	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	XP_006528028.1	Gene:	Zfx / 22764	MGIID:	99211	Length:	832	Species:	Mus musculus

Alignment Length:	804	Identity:	138/804 - (17%)
Similarity:	266/804 - (33%)	Gaps:	292/804 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 MIQKCFP-TLQILQDDTLPKEICQECCLQLERF--SQFIDVVMLAQSELQRKYRRQLKIKQEPLV 206
            ::..|:| |..:|.|:.|  :...|..|:|::.  :.|.|......:.:.   ..|:.::.:..|
Mouse    14 LLLACYPDTSGVLADENL--KAMDEDGLELQQQAPNSFFDATGAGATHMD---GNQIVVEVQETV 73

  Fly   207 RVKQ--EACESLDNLFPDELDMGLEQD---DGCDQEETEQKFQFCEFPMLNAQDIINNCDIMEII 266
            .|..  ::..::.|..||:.|..:.||   |...::             :...||::..|:.|.:
Mouse    74 YVSDVVDSDITVHNYVPDDPDSVVIQDVIEDVVIED-------------VQCTDIMDEADVSETV 125

  Fly   267 NLDDPFINIPDDADVGQSERLQPGRTANEMLQNELLTEEHNYAKEEWQLPPHQYKTEKVEGTDAA 331
            .:.:..:    |:||.:...|......:::|.:::.:...:       :|.|...:|.:..:|
Mouse   126 IIPEQVL----DSDVTEEVSLTHCTVPDDVLASDITSASIS-------MPEHVLTSESIHVSD-- 177

  Fly   332 PDAAPPPADPPPLQDNIDPPSAPEPRSCKPIVTNVSQIPNPMI--CELLPQPAPPTSIKPNIVV- 393
                                           |.:|..:.:..:  .|::..|.....:...::|
Mouse   178 -------------------------------VGHVEHVVHDSVVEAEIVTDPLAADVVSEEVLVA 211

  Fly   394 --LNDSVVESSAA------FRLHNCTLCTAKFITIDSLNQHYAHSHSNSTPMVSVPPMNICLPSL 450
              .:::|::::..      ...:||.  ....|::|...: ..|..|:...|.:...::.|....
Mouse   212 DCASEAVIDANGIPVNQQDEEKNNCE--DYLMISLDDAGK-IEHDGSSGLTMDNETEIDPCKVDG 273

  Fly   451 TMNPPMKM---------ESNRGLVATEQSEYWPLEWH-------NSPVSKQPRKKIDILDMQSSF 499
            |....:|:         :...|.|...:||  |...|       |:.: :.||:|:..:.:..|.
Mouse   274 TCPEVIKVYIFKADPGEDDLGGTVDIVESE--PENEHGVELLDPNNSI-RVPREKMVYMAVNDSQ 335

  Fly   500 LHHKDL-----------------IPTATQLSAPAPDPQL----------VAVTASY--------- 528
            ...::|                 ...|...:|...:.|:          :|..|:|
Mouse   336 QEEEELNVAEIADEVYMEVIVGEEDAAAAAAAAVHEQQVEDNEMKTFMPIAWAAAYGNNSDGIEN 400

  Fly   529 -----------------AKLANRYRKLQLK--------------------------C-KKLKS-- 547
                             .:||.:..|.:.:                          | ||.||
Mouse   401 RNGTASALLHIDESAGLGRLAKQKPKKRRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRG 465

  Fly   548 ---------PRKVHRKTYVCRMCRKGFSKFKNLHHH--------RRQKA--------HFV----- 582
                     |..:.:|.|.|..|....:|..:||:|        :.:||        ||.
Mouse   466 FLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHLESHKLTSKAEKAIECDECGKHFSHAGAL 530

  Fly   583 ---KLI----------------------------------PNFSGRCSGCLKFFRSRLGLRQHMR 610
               |::                                  .||...|..|.|.||....|::|||
Mouse   531 FTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAVHSKNFPHICVECGKGFRHPSELKKHMR 595

  Fly   611 YICQSLSLKNHRRLQSFKCRHCQAIAFAHWRLYRRHELNCRPKKSKTKVQTAMNSKKKVTPTQVF 675
            .         |...:.::|::|:         ||    :......||.|:|      |.:....|
Mouse   596 I---------HTGEKPYECQYCE---------YR----SADSSNLKTHVKT------KHSKEMPF 632

  Fly   676 ECNICKKSFGSLNGLRQHNITHSTERQHKCGICERVFKRRNGLSQHIKGYHLQLKPHECPVCQ-- 738
            :|:||..:|.....::||.:.|...:.|:|..|:......:.|.:||...|.:..||:|.:|.
Mouse   633 KCDICLLTFSDTKEVQQHALVHQESKTHQCLHCDHKSSNSSDLKRHIISVHTKDYPHKCDMCDKG 697

  Fly   739 -HRYA-LK--------CDMLRCRH 752
             ||.: ||        ..|.:|||
Mouse   698 FHRPSELKKHVAAHKGKKMHQCRH 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10431	NP_001286078.1	THAP	4..81	CDD:283206
		zf-AD	123..192	CDD:214871	11/49 (22%)
		zf-C2H2_6	674..700	CDD:290623	8/25 (32%)
		C2H2 Zn finger	677..697	CDD:275368	6/19 (32%)
		C2H2 Zn finger	705..726	CDD:275368	5/20 (25%)
Zfx	XP_006528028.1	Zfx_Zfy_act	104..437	CDD:368066	51/395 (13%)
		zf-C2H2	452..474	CDD:333835	5/21 (24%)
		C2H2 Zn finger	454..474	CDD:275368	5/19 (26%)
		C2H2 Zn finger	485..509	CDD:275368	6/23 (26%)
		C2H2 Zn finger	517..537	CDD:275368	3/19 (16%)
		COG5048	570..>832	CDD:227381	48/180 (27%)
		C2H2 Zn finger	577..597	CDD:275368	9/28 (32%)
		C2H2 Zn finger	605..624	CDD:275368	7/31 (23%)
		C2H2 Zn finger	662..683	CDD:275368	5/20 (25%)
		C2H2 Zn finger	691..711	CDD:275368	6/19 (32%)
		C2H2 Zn finger	748..768	CDD:275368
		C2H2 Zn finger	776..797	CDD:275368
		C2H2 Zn finger	805..825	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100