DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10431 and CTCFL

DIOPT Version :9

Sequence 1:NP_001286078.1 Gene:CG10431 / 35157 FlyBaseID:FBgn0032730 Length:762 Species:Drosophila melanogaster
Sequence 2:NP_001255972.1 Gene:CTCFL / 140690 HGNCID:16234 Length:700 Species:Homo sapiens


Alignment Length:685 Identity:136/685 - (19%)
Similarity:231/685 - (33%) Gaps:207/685 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   141 ELFGMIQKCFPTLQILQDDTLPKE----ICQE------CCLQLERFS-QFIDVVM-------LAQ 187
            |.|..|::    |:::.:..|.:|    :|:|      ..|:.||.| .|.|.|:       ||.
Human    11 EQFTKIKE----LELMPEKGLKEEEKDGVCREKDHRSPSELEAERTSGAFQDSVLEEEVELVLAP 71

  Fly   188 SELQRKYRRQLKIKQEPLVRVKQEACESLDNLFPDELDMGLEQDDGCD-------------QEET 239
            ||...||...|:     .|....||.|..|...     :.::|.:|..             :|..
Human    72 SEESEKYILTLQ-----TVHFTSEAVELQDMSL-----LSIQQQEGVQVVVQQPGPGLLWLEEGP 126

  Fly   240 EQKFQFCEFPMLNAQDIINNCDIMEIIN---LDDPFINIPDDADVGQSERLQPG--RTANEMLQN 299
            .|..|.|  ..::.|..:.:...||::.   |::..:...:|:.:..|.....|  :...|..:|
Human   127 RQSLQQC--VAISIQQELYSPQEMEVLQFHALEENVMVASEDSKLAVSLAETTGLIKLEEEQEKN 189

  Fly   300 ELLTEEHNYAKEEWQLPPHQYKTEKVEGTDAAPDAAPPPADPPPLQDNIDPPSAPEPRSCKPIVT 364
            :||.|.   .||:      .:..|.:.| |...|..........:::..|.|:|.:..:.|...|
Human   190 QLLAER---TKEQ------LFFVETMSG-DERSDEIVLTVSNSNVEEQEDQPTAGQADAEKAKST 244

  Fly   365 ---------------NVSQIPNPMICELLPQPAPPTSIKPNI----------VVLNDSVVESSAA 404
                           :|....:..:..........||.||::          |.|..:.|.:...
Human   245 KNQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHLCLKTFRTVTLLRNHVNTHTG 309

  Fly   405 FRLHNCTLCTAKFITIDSLNQHYAHSHSNSTPMVSVPPMNICLPSLTMNPPMKMESNRGLVATEQ 469
            .|.:.|..|...|:|...|.:|..:.|::..|.           ..:|.....:|:::       
Human   310 TRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPF-----------KCSMCKYASVEASK------- 356

  Fly   470 SEYWPLEWH-NSPVSKQPRKKIDILDMQSSFLHHKDLIPTATQLSAPAPDPQLVAVTASYAKLAN 533
                 |:.| .|...::|                                  ......|||. .:
Human   357 -----LKRHVRSHTGERP----------------------------------FQCCQCSYAS-RD 381

  Fly   534 RYRKLQLKCKKLKSPRKVH--RKTYVCRMCRKGFSKFKNLHHHRRQKAHFVKLIPNFSGRCSGCL 596
            .|        |||...:.|  .|.|.|.:|...|::...:..|..||  ..:.:|.:  :|..|.
Human   382 TY--------KLKRHMRTHSGEKPYECHICHTRFTQSGTMKIHILQK--HGENVPKY--QCPHCA 434

  Fly   597 KFFRSRLGLRQHMR----YICQSLSLKNHRRLQSFKCRHCQAIAFAHWRLYRRHELNCRPKKSKT 657
            .....:..||.|||    |....|           |||:|.|:....:.|. :|:          
Human   435 TIIARKSDLRVHMRNLHAYSAAEL-----------KCRYCSAVFHERYALI-QHQ---------- 477

  Fly   658 KVQTAMNSKKKVTPTQVFECNICKKSFGSLNGLRQHNITHSTERQHKCGICERVFKRRNGLSQHI 722
              :|..|.|:       |:|..|..:......:..|..||:.|:...|..|.:.|:::..|:.|.
Human   478 --KTHKNEKR-------FKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHF 533

  Fly   723 KGYH-LQLKP--HECPVC---------QHRYALKC 745
            :.|| ....|  ::|..|         .||::.||
Human   534 RKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKC 568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10431NP_001286078.1 THAP 4..81 CDD:283206
zf-AD 123..192 CDD:214871 19/68 (28%)
zf-C2H2_6 674..700 CDD:290623 6/25 (24%)
C2H2 Zn finger 677..697 CDD:275368 3/19 (16%)
C2H2 Zn finger 705..726 CDD:275368 5/20 (25%)
CTCFLNP_001255972.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..55 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..250 5/28 (18%)
COG5048 <259..403 CDD:227381 34/209 (16%)
C2H2 Zn finger 259..279 CDD:275368 1/19 (5%)
zf-H2C2_2 271..296 CDD:290200 4/24 (17%)
C2H2 Zn finger 287..307 CDD:275368 3/19 (16%)
zf-H2C2_2 300..324 CDD:290200 5/23 (22%)
C2H2 Zn finger 315..333 CDD:275368 6/17 (35%)
C2H2 Zn finger 344..364 CDD:275368 4/31 (13%)
zf-H2C2_2 357..378 CDD:290200 5/54 (9%)
C2H2 Zn finger 372..392 CDD:275368 7/28 (25%)
zf-H2C2_2 385..409 CDD:290200 8/23 (35%)
C2H2 Zn finger 400..417 CDD:275368 3/16 (19%)
C2H2 Zn finger 430..448 CDD:275368 5/17 (29%)
C2H2 Zn finger 460..480 CDD:275368 6/32 (19%)
C2H2 Zn finger 488..508 CDD:275368 3/19 (16%)
zf-H2C2_2 500..525 CDD:290200 7/24 (29%)
C2H2 Zn finger 516..534 CDD:275368 5/17 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..630 136/685 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24406
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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