DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10431 and LOC103694540

DIOPT Version :9

Sequence 1:	NP_001286078.1	Gene:	CG10431 / 35157	FlyBaseID:	FBgn0032730	Length:	762	Species:	Drosophila melanogaster
Sequence 2:	XP_038956652.1	Gene:	LOC103694540 / 103694540	RGDID:	9203794	Length:	781	Species:	Rattus norvegicus

Alignment Length:	771	Identity:	152/771 - (19%)
Similarity:	256/771 - (33%)	Gaps:	240/771 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EDFNCSN--NRKTLKKNAVPSIRVSEDDSMSGHLEQVSPSNRPTHKQTLSSAAESAATGVKATCR 124
            ||.:|||  ....:..|.:...:|.:.|:    .|:||.:..|......||...::.|..:   .
  Rat    72 EDVHCSNILEETDISDNVIIPEQVLDLDT----AEEVSLAQFPIPDILASSITSTSLTMPE---H 129

  Fly   125 FCGSSAINCSSFDKSFELFGMIQKCFPTLQILQD---------DTLPKEICQ----ECCLQLERF 176
            ...|.||:.|.       .|.|:      |::.|         |.|..:|.:    :|..:
  Rat   130 ILMSEAIHVSD-------VGHIE------QVIHDSLVETEVITDPLTADISEILVTDCASE---- 177

  Fly   177 SQFIDVVMLAQSELQRKYRRQLKIKQEPLVRVKQEACESLDNLFPDELDMGLEQDDGCDQEETEQ 241
                  .:|..|.:..:.:...|:.::..:.:      |||       |.|..:::|..:..|..
  Rat   178 ------AVLDSSGMPLEQQDDTKVNRDDYLMI------SLD-------DAGKTENEGSSEVTTNA 223

  Fly   242 KFQFCEFPMLN--AQDIINNCDIMEIINLDDPFINIPDDADVGQSERLQPGRTAN----EML--- 297
            :.:...: .||  :.::|.    :.|...|      |::.|||::..:...:|.|    |::
  Rat   224 ESESDPY-KLNETSPEVIK----VYIFKAD------PEEDDVGETVDIVESKTDNGNEAEVIDQS 277

  Fly   298 -------QNELLTEEHNYAKEEWQLPPHQYKTEKVEGTDAAPDAAPPPADPPPLQDNIDPPSAPE 355
                   .|..:....:..:||        .|:.:.|.:.|.|.|...::.....|:.:..:|..
  Rat   278 SSIYVPRDNVYMPVSDSQKEEE--------DTKVIVGDEDAGDTAADTSEHEQQMDDSEIKAAFL 334

  Fly   356 PRSCKPIVTNVSQIPNPMICELLPQPAPPTSIKPNIVVLNDSVVESSAAFRLHN----------- 409
            |.:......|.|.       |:..|....::      ||:.:  ||....|:|.
  Rat   335 PIAWAAAYDNNSD-------EIEEQNVTASA------VLHQN--ESGGLDRVHKQKAKKKKRPES 384

  Fly   410 --------------------CTLCTAKFITIDSLNQHYAHSHSNSTPMVSVPPMNICLPSLTMNP 454
                                |..|..||.|...|.:|                        ..|.
  Rat   385 KQYQTAIIVAPDGQTLIVYPCMFCGKKFKTKSFLKRH------------------------IKNH 425

  Fly   455 PMKMESNRGLVATEQSEYWPLEWHNSPVSKQPRKKIDILDMQSSFLHHKDLIPTATQLSAPAPDP 519
            |..:...:              :|.:.......|||.:.:...|   ||..|.|...........
  Rat   426 PEYLAKKK--------------YHCTDCDYSTNKKISLHNHMES---HKLTIKTEKTTECDDCGK 473

  Fly   520 QLVAVTASYAKLANRYRKLQLKCKKLKSPRKVHRKTYVCRMCRKGFSKFKNLHHHRRQKAHFVKL 584
            .|     |:|...         |...|...|| .|||.|:.|....::..:|:||  ..|...|.
  Rat   474 HL-----SHAGTL---------CTHKKEKEKV-SKTYKCKFCDYETAEQTSLNHH--LLAVHSKK 521

  Fly   585 IPNFSGRCSGCLKFFRSRLGLRQHMRYICQSLSLKNHRRLQSFKCRHCQAIAFAHWRLYRRHELN 649
            .|:.   |..|.|.||....|::|:|.         |...:.::|::|:         |:    :
  Rat   522 YPHV---CVECGKGFRHPSELKKHIRV---------HTGEKPYQCQYCE---------YK----S 561

  Fly   650 CRPKKSKTKVQTAMNSKKKVTPTQVFECNICKKSFGSLNGLRQHNITHSTERQHKCGICERVFKR 714
            ......||.::|   ...|..|   .:|.||..:|......:||.:.|...|.|:|..|......
  Rat   562 ADSSNLKTHIKT---KHSKDIP---LKCGICLMTFSDTKEAQQHALIHQENRTHQCSYCNHKSSN 620

  Fly   715 RNGLSQHIKGYHLQLKPHECPVCQ---HRYA-LK--------CDMLRCRHSLRKGP 758
            .:.|.:||...|.:..||:|.:|.   ||.: ||        ..|.:|||...|.|
  Rat   621 SSDLKRHIISVHTKDYPHKCDMCSKGFHRPSELKKHVATHKSKKMHQCRHCDFKSP 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10431	NP_001286078.1	THAP	4..81	CDD:283206	6/20 (30%)
		zf-AD	123..192	CDD:214871	14/81 (17%)
		zf-C2H2_6	674..700	CDD:290623	7/25 (28%)
		C2H2 Zn finger	677..697	CDD:275368	6/19 (32%)
		C2H2 Zn finger	705..726	CDD:275368	5/20 (25%)
LOC103694540	XP_038956652.1	Zfx_Zfy_act	68..388	CDD:398398	70/392 (18%)
		zf-C2H2	403..425	CDD:395048	7/45 (16%)
		C2H2 Zn finger	405..425	CDD:275368	7/43 (16%)
		C2H2 Zn finger	436..456	CDD:275368	4/22 (18%)
		C2H2 Zn finger	468..484	CDD:275368	4/29 (14%)
		C2H2 Zn finger	497..518	CDD:275368	6/22 (27%)
		COG5048	508..>694	CDD:227381	52/202 (26%)
		C2H2 Zn finger	526..546	CDD:275368	8/28 (29%)
		zf-H2C2_2	538..562	CDD:404364	7/45 (16%)
		C2H2 Zn finger	554..573	CDD:275368	5/31 (16%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		C2H2 Zn finger	611..632	CDD:275368	5/20 (25%)
		C2H2 Zn finger	640..689	CDD:275368	12/37 (32%)
		zf-C2H2	695..717	CDD:395048
		C2H2 Zn finger	697..717	CDD:275368
		zf-H2C2_2	709..733	CDD:404364
		C2H2 Zn finger	725..746	CDD:275368
		C2H2 Zn finger	754..774	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24406
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100