DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment L2HGDH and AT3G56840

DIOPT Version :9

Sequence 1:	NP_001286076.1	Gene:	L2HGDH / 35156	FlyBaseID:	FBgn0032729	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001319771.1	Gene:	AT3G56840 / 824851	AraportID:	AT3G56840	Length:	465	Species:	Arabidopsis thaliana

Alignment Length:	483	Identity:	146/483 - (30%)
Similarity:	212/483 - (43%)	Gaps:	101/483 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VRLLVQGLRR--SLLNV---------GVAAPNESTATHKRSQHSSSSCGDYDLVVVGGGIVGAAS 57
            :||..:.|:.  :|:||         |::...|:.|..:           .|.||:|.|:||.|.
plant    41 MRLSTRNLKPTWNLINVVDASKTIVRGISGGAETIAKER-----------VDTVVIGAGVVGLAV 94

  Fly    58 AREIVLRHPSLKVAVLEKECKLAKHQSGHNSGVIHAGIYYKPGTLKARLCVEGMHLAYAYLDEKK 122
            |||:.||  ..:|.:|:.........|..||.|:||||||.|.:|||:.||.|..|.|.|..|.:
plant    95 ARELSLR--GREVLILDAASSFGTVTSSRNSEVVHAGIYYPPNSLKAKFCVRGRELLYKYCSEYE 157

  Fly   123 IPYKKTGKLIVATDEKEVKLLKDLEKRGIANNVPDLRMIEGSEIQEIEPYCQGVMALHSPHTGIV 187
            ||:||.|||||||...|:..|..|...|..|.|..|||:||.|...:||..:.|.||.||.:||:
plant   158 IPHKKIGKLIVATGSSEIPKLDLLMHLGTQNRVSGLRMLEGFEAMRMEPQLRCVKALLSPESGIL 222

  Fly   188 D-----WGLVTEHYGQDFKQCGGDIYLDFNV-----------SKFTETKEGTDYPVTIHGAKPGQ 236
            |     ..||.|............:.|:..|           ::|:|::...:          .|
plant   223 DTHSFMLSLVGEAQNNHATFSYNTVVLNGRVEEKKMHLYVADTRFSESRCEAE----------AQ 277

  Fly   237 TVRTKN-VLTCGGLQSDLLAEKT-GCPRDPRIVP----FRGEYLLLTKEKQHMVKGNIYPVPDPR 295
            .....| |:...||.:..||::. |.  |.|.||    .||.|..|:..|.......:||:|:.
plant   278 LELIPNLVVNSAGLGAQALAKRLHGL--DHRFVPSSHYARGCYFTLSGIKAPPFNKLVYPIPEE- 339

  Fly   296 FPFLGVHFTPRMDGSIWLGPNAVLALKREGYTW----GDINLF-ELFDALRYPGFVKMASKYIGF 355
             ..||||.|..::|.:..||:.         .|    .|.:.| ..||....|
plant   340 -GGLGVHVTVDLNGLVKFGPDV---------EWIECTDDTSSFLNKFDYRVNP------------ 382

  Fly   356 GLSEMSKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMDLDG--NLVDDFVFDRGQGSGAL 418
               :.|:.::     ..::||.||:.:..::.|.:|:|.:   |.|  ....|||....:..|
plant   383 ---QRSEKFY-----PEIRKYYPDLKDGSLEPGYSGIRPK---LSGPKQSPADFVIQGEETHG-- 434

  Fly   419 AKRVLHCRNAPSPGATSSLAIAKMIADK 446
            ...:::.....|||.|||||||:.||:|
plant   435 VPGLVNLFGIESPGLTSSLAIAEHIANK 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
L2HGDH	NP_001286076.1	PRK11728	56..447	CDD:183292	130/420 (31%)
L2HGDH	NP_001286076.1	NADB_Rossmann	69..440	CDD:304358	119/399 (30%)
AT3G56840	NP_001319771.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	139	1.000	Domainoid score	I1558
eggNOG	1	0.900	-	-		E1_COG0579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I1788
OMA	1	1.010	-	-		QHG61343
OrthoDB	1	1.010	-	-		D1310154at2759
OrthoFinder	1	1.000	-	-		FOG0005741
OrthoInspector	1	1.000	-	-		oto2878
orthoMCL	1	0.900	-	-		OOG6_101318
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4135
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.740