DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment L2HGDH and L2HGDH

DIOPT Version :9

Sequence 1:	NP_001286076.1	Gene:	L2HGDH / 35156	FlyBaseID:	FBgn0032729	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_079160.1	Gene:	L2HGDH / 79944	HGNCID:	20499	Length:	463	Species:	Homo sapiens

Alignment Length:	424	Identity:	236/424 - (55%)
Similarity:	308/424 - (72%)	Gaps:	10/424 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SSSCGDYDLVVVGGGIVGAASAREIVLRHPSLKVAVLEKECKLAKHQSGHNSGVIHAGIYYKPGT 101
            |:|...:|:|:|||||||.||||.::||||||.:.|||||..||.||:||||||||:||||||.:
Human    43 SASTSSFDIVIVGGGIVGLASARALILRHPSLSIGVLEKEKDLAVHQTGHNSGVIHSGIYYKPES 107

  Fly   102 LKARLCVEGMHLAYAYLDEKKIPYKKTGKLIVATDEKEVKLLKDLEKRGIANNVPDLRMIEGSEI 166
            |||:|||:|..|.|.|..:|.|.||:.||||||.:::|:..|:.|.::|:.|.||.||:|:..:|
Human   108 LKAKLCVQGAALLYEYCQQKGISYKQCGKLIVAVEQEEIPRLQALYEKGLQNGVPGLRLIQQEDI 172

  Fly   167 QEIEPYCQGVMALHSPHTGIVDWGLVTEHYGQDFKQCGGDIYLDFNVSKFTETKE-------GTD 224
            ::.||||:|:||:..|||||||:..|...:.|||::.||.:..:|.|......||       |..
Human   173 KKKEPYCRGLMAIDCPHTGIVDYRQVALSFAQDFQEAGGSVLTNFEVKGIEMAKESPSRSIDGMQ 237

  Fly   225 YPVTIHGAKPGQTVRTKNVLTCGGLQSDLLAEKTGCPRDPRIVPFRGEYLLLTKEKQHMVKGNIY 289
            ||:.|...| |:.:|.:.|:||.||.||.::|.:||..|||||||||:||||..||.::||||||
Human   238 YPIVIKNTK-GEEIRCQYVVTCAGLYSDRISELSGCTPDPRIVPFRGDYLLLKPEKCYLVKGNIY 301

  Fly   290 PVPDPRFPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINLFELFDALRYPGFVKMASKYIG 354
            ||||.||||||||||||||||||||||||||.|||||...|.:..::.|.:...|.:|:||:...
Human   302 PVPDSRFPFLGVHFTPRMDGSIWLGPNAVLAFKREGYRPFDFSATDVMDIIINSGLIKLASQNFS 366

  Fly   355 FGLSEMSKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMDLDGNLVDDFVFDRGQGSGALA 419
            :|::||.|:.|:...:|.|||:||:||..||.||||||||||:|.|||||:|||||.|.|.  :.
Human   367 YGVTEMYKACFLGATVKYLQKFIPEITISDILRGPAGVRAQALDRDGNLVEDFVFDAGVGD--IG 429

  Fly   420 KRVLHCRNAPSPGATSSLAIAKMIADKIENEFSI 453
            .|:||.||||||.||||:||:.||||:::..|.:
Human   430 NRILHVRNAPSPAATSSIAISGMIADEVQQRFEL 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
L2HGDH	NP_001286076.1	PRK11728	56..447	CDD:183292	224/397 (56%)
L2HGDH	NP_001286076.1	NADB_Rossmann	69..440	CDD:304358	209/377 (55%)
L2HGDH	NP_079160.1	NADB_Rossmann	31..448	CDD:304358	231/411 (56%)
L2HGDH	NP_079160.1	PRK11728	61..457	CDD:183292	224/402 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140710
Domainoid	1	1.000	467	1.000	Domainoid score	I466
eggNOG	1	0.900	-	-		E1_COG0579
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11767
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1492
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61343
OrthoDB	1	1.010	-	-		D1310154at2759
OrthoFinder	1	1.000	-	-		FOG0005741
OrthoInspector	1	1.000	-	-		oto89275
orthoMCL	1	0.900	-	-		OOG6_101318
Panther	1	1.100	-	-	LDO	PTHR43104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2601
SonicParanoid	1	1.000	-	-		X4135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800