DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango6 and RTP1

DIOPT Version :9

Sequence 1:	NP_609922.2	Gene:	Tango6 / 35155	FlyBaseID:	FBgn0032728	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_013910.1	Gene:	RTP1 / 855223	SGDID:	S000004797	Length:	981	Species:	Saccharomyces cerevisiae

Alignment Length:	1010	Identity:	196/1010 - (19%)
Similarity:	361/1010 - (35%)	Gaps:	284/1010 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KALANTANNSGTAEALEINLRILEKYAKLEIGQQLHELCLEYQ-LTDDHESSIDPDSDRTICYII 81
            :||..:.||...|.       :|:|:      |.||...||.| ...:.:|.:.|.|...:.|:.
Yeast    59 QALKCSNNNEFVAV-------LLQKF------QNLHIHVLEQQRRLIESKSDLLPISLHDMKYVD 110

  Fly    82 RLQH--VLHSIMRNIN-------------------------------FHSDAKEDLISVAHLKLC 113
            .|.:  ::|.|..|::                               .::|....:|:|
Yeast   111 ELINLLIIHGIDANLSPTMKIPFDSKRINTFKKGQKSAEYETPRWHTINNDTLSQVITV------ 169

  Fly   114 IQASQELSYYSLRCQLHEDFYKSPIFCEAQGKIKANFSLMLLSIQFFINLLHIR---QYH---IA 172
                   .|..|..:...|:.:..|   ::|...||..|.|:       :||::   :|.   |.
Yeast   170 -------FYNVLTSERSSDYLREII---SKGSAYANILLGLI-------VLHLQLPNRYSSQMIT 217

  Fly   173 NSMELVQRDLLAAIVSLRVQ--QDSPLLDKAIAYLWQYESKADFFRNILLFKATTLCPTLAQLLH 235
            |..:..:...|..:.:|.|:  ||..:                  |..:|.|.|||
Yeast   218 NLEDTQETYTLFGVYTLLVETIQDEKV------------------REPILSKLTTL--------- 255

  Fly   236 RQLLGKLHLPQ-GFASLVEALHQNPNVNSSRNAEIVASIVARKGFSQLAQEKMVLQVLEY----- 294
                 .|..|: |..||::.      |...|:||.:......:.:..|..:...:..|:|
Yeast   256 -----TLRRPENGLISLIDF------VLGVRDAEDIDIEKFNRIYQILMSKPKTMTNLQYLTELF 309

  Fly   295 -----------------C------KFYLQNADKMCAGVLSLRRLYDLSDTNQKLIKEILFK---- 332
                             |      ||||:|           :|:  ::|...|.::.|:|.
Yeast   310 KQIYDGLTFVNRPILVTCLNGLILKFYLRN-----------KRI--VNDFLFKKVRSIIFNSPLT 361

  Fly   333 -HWETLCNPEDIINGLILM---DHQELCNRILLWQHLFCSSTVACLPSN--LLVPYLPLLLQLYD 391
             |  |.....|:||.||.:   ...:|.|.::    ..|.......|..  |.|....|.|:...
Yeast   362 DH--TAKELNDVINVLISLSKNSSSDLLNDLV----TSCPDEDGTTPGQFFLYVWIYALFLKKNQ 420

  Fly   392 GL-PMEL------------------PASSQISAIILRCLDNREMKNE----LPAILQKLFKWEIE 433
            .| |:|:                  .:||:...::|..|.:..:..|    |..:...|..:|.|
Yeast   421 KLDPLEINKLSISDNKSTDSIHFPEQSSSKYYEVVLSLLKSLIVITENFQYLNVLSLNLLNFEHE 485

  Fly   434 KEPPWKCLNPRIIILP--SMNTTQIQVKVAHK--------DHLADHDMG-RILPGLLTSSSHHSL 487
            |   ||.|......||  |:..|.:......|        :.|.|.|:. .:....|...:....
Yeast   486 K---WKYLIDLDTQLPYISVKNTDMAELFFEKGSKNSQISEFLQDMDLSIELFMEFLVLLNDEEQ 547

  Fly   488 TCKVFLSLLGFIAKQINDKSSASVD------------FISSEAELKDFLHSKYQLKL-----DLL 535
            :..:||.:|.............|.|            .|..:.:|.:.::::::.|:     |:|
Yeast   548 SKTLFLDILKRWVHHTKKSEKRSSDNHSGMPSVTDNALILMDLKLLECMNNRFKTKIVNKPKDVL 612

  Fly   536 IALNQMVAHQPLRAQLSQHTKELLHILK---DLLVHRSREQDTTD----QILLLVLNLLQEILEG 593
            |.::|::       .:.|...|.:..::   |..|....|.:..|    ....::|.||..:|..
Yeast   613 IVIDQLI-------DVVQEKDETIQEVEADSDDEVEEGEETEELDPNENSSYKIILQLLSTVLSE 670

  Fly   594 SEN---IQLSEACKELKEQLHLLGTRSSN-PLIQQSVKSLLTIIHGAWRPSEAVKI----QPFQR 650
            |.:   :|.|...|.:..:|....|.:|. ..:..|:.::|...|...| ::.::|    :...:
Yeast   671 SSSSILLQNSYILKSISRKLQSFNTNASEIDALLASIDNILINGHTTER-NDNIEIEMDEERLDK 734

  Fly   651 ARSLIEEKQSHMQVYGIQMMIDLLKKRDPATLAQGQLIIALALTTLKDKESYTFLNCVRLFVSLV 715
            |.:.:.:....::.||:..:..|.:|:.|  :...:.::.:.|..||:.:.:.:||.::...:|.
Yeast   735 AITSLHDPLVPIKSYGLTELRHLAEKKSP--VISLEKVLQIHLDYLKNMDPFIYLNVIKGLTTLC 797

  Fly   716 HVMESDVLDKLSDEYLSETA--HLDYRLVVGEAILKVAQ---EL--GPLCFRYKAVLLNCFMYGS 773
            .:....:|..|::.|.::..  .||..|.|||..:...|   ||  |.|.:......|:......
Yeast   798 ELEPETILPLLAEFYANKKKKNRLDDVLKVGEVFINYIQRQNELFQGKLAYLIIDTCLSIVRPND 862

  Fly   774 RSPV-HEFRMSAFANLAQLCRLLAFQVQNFFHELLQLVNSEL---TTGGYVPSK-------RAAV 827
            ..|: :.:|||:.:.|....::.|..|.:...::|..|...|   ....::..|       |:||
Yeast   863 SKPLDNRWRMSSMSILGMCLQINARGVSDRIRDMLDCVFGILQLEQPQNHLKDKDDSFLMRRSAV 927

  Fly   828 LVLAELL--NGMENLLDYQEMLLPI---YRLLKAI 857
            .::.:||  .|.:        |||.   |..||.:
Yeast   928 HLIHDLLYSTGFD--------LLPFEYNYDKLKTL 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango6	NP_609922.2	RTP1_C1	650..750	CDD:287349	21/101 (21%)
RTP1	NP_013910.1	RTP1_C1	735..840	CDD:402124	22/106 (21%)
RTP1	NP_013910.1	RTP1_C2	947..979	CDD:402083	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4653
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR20959
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1862
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960