Protein Alignment Tango6 and TANGO6

DIOPT Version :10

• Sequence 1: NP_609922.2
• Gene: Tango6 / 35155
• FlyBaseID: FBgn0032728
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_078838.1
• Gene: TANGO6 / 79613
• HGNCID: 25749
• Length: 1094
• Species: Homo sapiens
• Alignment Length: 1061
• Identity: 208/1061 - (19%)
• Similarity: 389/1061 - (36%)
• Gaps: 312/1061 - (29%)

  Fly    62 TDDHESSIDPDS-----DRTICYIIRLQHVL---HSIMRNINFHSDAKEDLISVAHLKLCIQASQ 118
            |.:...::.||:     .:|:.::::....|   ..:|..:......:.:..:|....:|..|:.
Human   125 TPEVAPALSPDALSISQQKTVQFVLQFVVTLGICPYLMPGVGVPLRYRTEFGAVVQDVVCFDAAP 189

  Fly   119 ELS---YYSLRCQLH---EDFYKSPIFCEAQGKIKANFSLMLLSIQFFINLLHIRQYHIANSMEL 177
            :.:   |.|.:..|:   .....|.|||...|.|.|.    |..:.|.                .
Human   190 DATRRLYTSCKALLNVAQHTSLGSLIFCHHFGDIAAG----LCQLGFC----------------P 234

  Fly   178 VQRDLLAAIVSLRVQQDSPLLDKAIAYLWQYESKADFFRNILLF-----------KATTLC--PT 229
            .:|.||.....:..:::..|...|:..:.....:....|.:|:.           |....|  |.
Human   235 TKRKLLTPAEEVLTEEERTLSRGALRDMLDQVYQPLAVRELLILQGGPPQSCTDVKTQMRCRAPA 299

  Fly   230 LAQLLHRQLLG-KLHLPQGFASLVEALHQNPNVNSS------------RNAEIVASIVARKGFSQ 281
            ..:.|..|||. :|..|.|..::|..:.:.....::            :..:::|.|:|......
Human   300 WLRRLCGQLLSERLMRPNGVQAVVRGILEGAGAGAAGGSDAEVTAADWKKCDLIAKILASCPQQS 364

  Fly   282 LAQEK----MVLQVLEYCKFYLQNADKMCAGVLSLRRLYDLSDTN-------------QKLIKEI 329
            |:.|.    :..|||:.  |:.|  ||:.|     |:...::.|.             :.|::.:
Human   365 LSPENYYRDICPQVLDL--FHFQ--DKLTA-----RQFQRVATTTFITLSRERPHLAAKYLLQPV 420

  Fly   330 LFKHWETLCNPE----DIINGLILMDHQEL--CNRILLWQHLFCSSTVACLPSNLLVPYLPLLLQ 388
            |......|...|    |::.|.||:..:||  |...:...::..:..:..|..:|| |.|.:|..
Human   421 LAPLHRCLNTAELSESDMVPGTILVTEEELSRCIEDVFKVYVVGNEPLTVLMDSLL-PVLGVLFL 484

  Fly   389 LYDGLPMELPASSQISAIILRCLDNREMKNELPAILQKLFKW---EIEKEPPWKCLNPRIII--- 447
            ||                   |. .::..:.:.::.|::..|   ::|::.....|.....:
Human   485 LY-------------------CF-TKQSVSHIRSLCQEILLWILGKLERKKAIASLKGFAGLDKA 529

  Fly   448 LPSMNT-------TQIQVKVAHKDHLADHD------------MGRI--LPGLLTSSSHHSLTCKV 491
            :||:::       ||..:.:..|:.::|.|            .||:  |..||:    |...|.:
Human   530 VPSLHSLCQFRVATQGGIMITIKEAISDEDEDEALYQKVSSEQGRVEHLGDLLS----HCQECGL 590

  Fly   492 FLSLLGFIAKQINDKSSASVDFISSEAELK-DFLHSKYQLKLDLLIALNQMVAHQPLRAQLSQHT 555
            ......|..|::...:|      .:|.||| :...||..|:|:         .||.|..: .|..
Human   591 AGDFFIFCLKELTHVAS------ENETELKTEPFSSKSLLELE---------QHQTLLVE-GQER 639

  Fly   556 KELLHILKDLLVHRSREQDTTD-----------------------------QILLLVLNLLQEIL 591
            |.|:..|..:|..|..||..|:                             |.|.:.:.|:..:|
Human   640 KLLVLQLMAVLCERMSEQIFTNVTQVVDFVAATLQRACASLAHQAESTVESQTLSMSMGLVAVML 704

  Fly   592 EGSENIQLSE--ACKELKEQLHLLGTRSSNPLIQQ-SVKSLLTI-IHGAWRPSEAVKI------- 645
            .|:..::.|:  ..|:|...|..:.....:|:||: :|...:|| .|||: .:|||.:
Human   705 GGAVQLKSSDFAVLKQLLPLLEKVSNTYPDPVIQELAVDLRITISTHGAF-ATEAVSMAAQSTLN 768

  Fly   646 -----------------QPFQRARSLIEEKQSH-------------------------------- 661
                             :|...|.|.:|::|||
Human   769 RKDLEGKIEEQQQTSHERPTDVAHSHLEQQQSHETAPQTGLQSNAPIIPQGVNEPSTTTSQKSGS 833

  Fly   662 ----------MQVY---------GIQMMIDLLKKRDPATLAQGQLIIALALTTLKDKESYTFLNC 707
                      :..|         .::.:...:::|:...|...:.::.:.|..|:.::::.:|:.
Human   834 VTTEQLQEVLLSAYDPQIPTRAAALRTLSHWIEQREAKALEMQEKLLKIFLENLEHEDTFVYLSA 898

  Fly   708 VRLFVSLVHVMESDVL-------DKLSDEYLSETAHLDYRLVVGEAILKVAQELGPLCFRYKAVL 765
            ::....|..|....:|       |...|::..||     |:.|||.::::.:.||.:..:|:..|
Human   899 IQGVALLSDVYPEKILPDLLAQYDSSKDKHTPET-----RMKVGEVLMRIVRALGDMVSKYREPL 958

  Fly   766 LNCFMYGSRSPVHEFRMSAFANLAQLCRLLAFQVQNFFHELLQLVNSELTTGGYVPSKRAAVLVL 830
            ::.|:.|.|.|....|.|:.|||.:||:.|.|.:.:..||:...:.:...|.|.|..:|||:.|:
Human   959 IHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVV 1023

  Fly   831 AELLNGMENLLD--YQEMLLPIYRLLKAIEADESCDPQMRQHAANGLKILNKKCTKLIQSALEE- 892
            ..||.|:.....  ...:|..:|.|||.:...|. |...:.||               |.||||
Human  1024 VLLLRGLSQKATEVLSAVLKDLYHLLKHVVCLEP-DDVAKLHA---------------QLALEEL 1072

  Fly   893 -----------KSLQKQIKVL 902
                       :.|:|:|.||
Human  1073 DDIMKNFLFPPQKLEKKIMVL 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango6	NP_609922.2	RTP1_C1	648..757	CDD:463059	25/166 (15%)
		RTP1_C2	846..879	CDD:431206	9/32 (28%)
TANGO6	NP_078838.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..834		7/56 (13%)
		HEAT repeat	838..867	CDD:293787	1/28 (4%)
		RTP1_C1	839..950	CDD:463059	19/115 (17%)
		HEAT 1	873..909		5/35 (14%)
		HEAT repeat	879..907	CDD:293787	4/27 (15%)
		HEAT repeat	912..946	CDD:293787	9/38 (24%)
		HEAT 2	952..988		13/35 (37%)
		HEAT repeat	957..983	CDD:293787	10/25 (40%)
		HEAT repeat	996..1026	CDD:293787	9/29 (31%)
		RTP1_C2	1041..1074	CDD:431206	14/48 (29%)