DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango6 and TANGO6

DIOPT Version :9

Sequence 1:	NP_609922.2	Gene:	Tango6 / 35155	FlyBaseID:	FBgn0032728	Length:	921	Species:	Drosophila melanogaster
Sequence 2:	NP_078838.1	Gene:	TANGO6 / 79613	HGNCID:	25749	Length:	1094	Species:	Homo sapiens

Alignment Length:	1061	Identity:	208/1061 - (19%)
Similarity:	389/1061 - (36%)	Gaps:	312/1061 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 TDDHESSIDPDS-----DRTICYIIRLQHVL---HSIMRNINFHSDAKEDLISVAHLKLCIQASQ 118
            |.:...::.||:     .:|:.::::....|   ..:|..:......:.:..:|....:|..|:.
Human   125 TPEVAPALSPDALSISQQKTVQFVLQFVVTLGICPYLMPGVGVPLRYRTEFGAVVQDVVCFDAAP 189

  Fly   119 ELS---YYSLRCQLH---EDFYKSPIFCEAQGKIKANFSLMLLSIQFFINLLHIRQYHIANSMEL 177
            :.:   |.|.:..|:   .....|.|||...|.|.|.    |..:.|.                .
Human   190 DATRRLYTSCKALLNVAQHTSLGSLIFCHHFGDIAAG----LCQLGFC----------------P 234

  Fly   178 VQRDLLAAIVSLRVQQDSPLLDKAIAYLWQYESKADFFRNILLF-----------KATTLC--PT 229
            .:|.||.....:..:::..|...|:..:.....:....|.:|:.           |....|  |.
Human   235 TKRKLLTPAEEVLTEEERTLSRGALRDMLDQVYQPLAVRELLILQGGPPQSCTDVKTQMRCRAPA 299

  Fly   230 LAQLLHRQLLG-KLHLPQGFASLVEALHQNPNVNSS------------RNAEIVASIVARKGFSQ 281
            ..:.|..|||. :|..|.|..::|..:.:.....::            :..:::|.|:|......
Human   300 WLRRLCGQLLSERLMRPNGVQAVVRGILEGAGAGAAGGSDAEVTAADWKKCDLIAKILASCPQQS 364

  Fly   282 LAQEK----MVLQVLEYCKFYLQNADKMCAGVLSLRRLYDLSDTN-------------QKLIKEI 329
            |:.|.    :..|||:.  |:.|  ||:.|     |:...::.|.             :.|::.:
Human   365 LSPENYYRDICPQVLDL--FHFQ--DKLTA-----RQFQRVATTTFITLSRERPHLAAKYLLQPV 420

  Fly   330 LFKHWETLCNPE----DIINGLILMDHQEL--CNRILLWQHLFCSSTVACLPSNLLVPYLPLLLQ 388
            |......|...|    |::.|.||:..:||  |...:...::..:..:..|..:|| |.|.:|..
Human   421 LAPLHRCLNTAELSESDMVPGTILVTEEELSRCIEDVFKVYVVGNEPLTVLMDSLL-PVLGVLFL 484

  Fly   389 LYDGLPMELPASSQISAIILRCLDNREMKNELPAILQKLFKW---EIEKEPPWKCLNPRIII--- 447
            ||                   |. .::..:.:.::.|::..|   ::|::.....|.....:
Human   485 LY-------------------CF-TKQSVSHIRSLCQEILLWILGKLERKKAIASLKGFAGLDKA 529

  Fly   448 LPSMNT-------TQIQVKVAHKDHLADHD------------MGRI--LPGLLTSSSHHSLTCKV 491
            :||:::       ||..:.:..|:.::|.|            .||:  |..||:    |...|.:
Human   530 VPSLHSLCQFRVATQGGIMITIKEAISDEDEDEALYQKVSSEQGRVEHLGDLLS----HCQECGL 590

  Fly   492 FLSLLGFIAKQINDKSSASVDFISSEAELK-DFLHSKYQLKLDLLIALNQMVAHQPLRAQLSQHT 555
            ......|..|::...:|      .:|.||| :...||..|:|:         .||.|..: .|..
Human   591 AGDFFIFCLKELTHVAS------ENETELKTEPFSSKSLLELE---------QHQTLLVE-GQER 639

  Fly   556 KELLHILKDLLVHRSREQDTTD-----------------------------QILLLVLNLLQEIL 591
            |.|:..|..:|..|..||..|:                             |.|.:.:.|:..:|
Human   640 KLLVLQLMAVLCERMSEQIFTNVTQVVDFVAATLQRACASLAHQAESTVESQTLSMSMGLVAVML 704

  Fly   592 EGSENIQLSE--ACKELKEQLHLLGTRSSNPLIQQ-SVKSLLTI-IHGAWRPSEAVKI------- 645
            .|:..::.|:  ..|:|...|..:.....:|:||: :|...:|| .|||: .:|||.:
Human   705 GGAVQLKSSDFAVLKQLLPLLEKVSNTYPDPVIQELAVDLRITISTHGAF-ATEAVSMAAQSTLN 768

  Fly   646 -----------------QPFQRARSLIEEKQSH-------------------------------- 661
                             :|...|.|.:|::|||
Human   769 RKDLEGKIEEQQQTSHERPTDVAHSHLEQQQSHETAPQTGLQSNAPIIPQGVNEPSTTTSQKSGS 833

  Fly   662 ----------MQVY---------GIQMMIDLLKKRDPATLAQGQLIIALALTTLKDKESYTFLNC 707
                      :..|         .::.:...:::|:...|...:.::.:.|..|:.::::.:|:.
Human   834 VTTEQLQEVLLSAYDPQIPTRAAALRTLSHWIEQREAKALEMQEKLLKIFLENLEHEDTFVYLSA 898

  Fly   708 VRLFVSLVHVMESDVL-------DKLSDEYLSETAHLDYRLVVGEAILKVAQELGPLCFRYKAVL 765
            ::....|..|....:|       |...|::..||     |:.|||.::::.:.||.:..:|:..|
Human   899 IQGVALLSDVYPEKILPDLLAQYDSSKDKHTPET-----RMKVGEVLMRIVRALGDMVSKYREPL 958

  Fly   766 LNCFMYGSRSPVHEFRMSAFANLAQLCRLLAFQVQNFFHELLQLVNSELTTGGYVPSKRAAVLVL 830
            ::.|:.|.|.|....|.|:.|||.:||:.|.|.:.:..||:...:.:...|.|.|..:|||:.|:
Human   959 IHTFLRGVRDPDGAHRASSLANLGELCQRLDFLLGSVVHEVTACLIAVAKTDGEVQVRRAAIHVV 1023

  Fly   831 AELLNGMENLLD--YQEMLLPIYRLLKAIEADESCDPQMRQHAANGLKILNKKCTKLIQSALEE- 892
            ..||.|:.....  ...:|..:|.|||.:...|. |...:.||               |.||||
Human  1024 VLLLRGLSQKATEVLSAVLKDLYHLLKHVVCLEP-DDVAKLHA---------------QLALEEL 1072

  Fly   893 -----------KSLQKQIKVL 902
                       :.|:|:|.||
Human  1073 DDIMKNFLFPPQKLEKKIMVL 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango6	NP_609922.2	RTP1_C1	650..750	CDD:287349	23/157 (15%)
TANGO6	NP_078838.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	777..834		7/56 (13%)
		HEAT repeat	838..867	CDD:293787	1/28 (4%)
		RTP1_C1	841..944	CDD:287349	17/107 (16%)
		HEAT 1	873..909		5/35 (14%)
		HEAT repeat	879..907	CDD:293787	4/27 (15%)
		HEAT repeat	912..946	CDD:293787	9/38 (24%)
		HEAT 2	952..988		13/35 (37%)
		HEAT repeat	957..983	CDD:293787	10/25 (40%)
		HEAT repeat	996..1026	CDD:293787	9/29 (31%)
		RTP1_C2	1042..1073	CDD:287297	14/46 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147861
Domainoid	1	1.000	50	1.000	Domainoid score	I11740
eggNOG	1	0.900	-	-		E1_KOG4653
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D365063at33208
OrthoFinder	1	1.000	-	-		FOG0004138
OrthoInspector	1	1.000	-	-		oto88734
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR20959
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1862
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.930