Protein Alignment Tango6 and Tango6

DIOPT Version :10

• Sequence 1: NP_609922.2
• Gene: Tango6 / 35155
• FlyBaseID: FBgn0032728
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_766625.1
• Gene: Tango6 / 272538
• MGIID: 2142786
• Length: 1079
• Species: Mus musculus
• Alignment Length: 1011
• Identity: 206/1011 - (20%)
• Similarity: 367/1011 - (36%)
• Gaps: 282/1011 - (27%)

  Fly    71 PDSDRT-----ICYIIRLQHVLHSIMRNINFHSDAKEDLISVAHLKLCIQASQELSYYSLRCQLH 130
            |..|||     :..::||:...|:..|                 |.:|.:...:|:.::....|
Mouse   171 PLRDRTEFGAVVQDVVRLEAAPHATRR-----------------LYICCRVLLDLAQHASLGSL- 217

  Fly   131 EDFYKSPIFCEAQGKIKANFSLMLLSIQFFINLLHIRQYHIANSMELVQRDLLAAIVSLRVQQDS 195
                   |||...|.|.|.    |..:.|.                ..:|.....:..:..:::.
Mouse   218 -------IFCRHFGDIAAG----LCQLGFC----------------PTKRKPPGPVEEVLTEEER 255

  Fly   196 PLLDKAIAYLWQYESKADFFRNILLF-----------KATTLCPTLAQLLHRQLLG-----KLHL 244
            .|..:|:..:.....:....|.:|..           |....|...|....|:|.|     :|..
Mouse   256 TLSRRALRDILDQVYQPLAVRELLTLQGGPRQPCTDVKTQLRCRAQAPAWLRRLCGQLLSERLMR 320

  Fly   245 PQGFASLVEALHQNPNVNSS------------RNAEIVASIVARKGFSQLAQEK----MVLQVLE 293
            |.|..::|..:.:.....::            |..:::|.|:|......|:.|.    :..|:|:
Mouse   321 PNGVQAVVRGILEGAGAGAAGGSDAEATAADWRKCDLIAKILASCPQQSLSPESYYKDICPQILD 385

  Fly   294 YCKFYLQNADKMCAGVLSLRRLYDLSDTN-------------QKLIKEILFKHWETLCNPE---- 341
            .  |:||  ||:.|     |:...::.|.             :.|::.:|......|...|
Mouse   386 L--FHLQ--DKLTA-----RQFQRVATTTFITLSRERPELAAKYLLQPMLAPLQRCLSTAEIPES 441

  Fly   342 DIINGLILMDHQEL--CNRILLWQHLFCSSTVACLPSNLLVPYLPLLLQLYDGLPMELP-ASSQI 403
            |::.|.||:..:||  |...:...::..:..|..|..:|| |.|.:...||......:. ..|..
Mouse   442 DMVPGAILVTEEELSRCVEDVFKVYVVANEPVPVLLDSLL-PLLRVFFSLYCFTQQSVSHIRSLC 505

  Fly   404 SAIILRCLDNREMKNELPAILQKLFKWEIEKEPPWKCLNPR----------III----------- 447
            ..|:|..|...|.|..:.::  |.|. .::|..|  .|:|:          |:|
Mouse   506 QEILLWILVKLERKKAIASL--KGFS-GLDKTVP--TLHPQCQFRAATHGGIVITAKEAISDDED 565

  Fly   448 ---LPSMNTTQIQVKVAHKDHLADHDMGRILPGLLTSSSHHSLTCKVFLSLLGFIAKQINDKSSA 509
               ...:::.|.||     :||.|         ||.......|....|:..|..::..:.|:.:.
Mouse   566 EALYQKVSSEQSQV-----EHLGD---------LLLHCQQCGLAGDFFIFCLKELSHLLEDREAE 616

  Fly   510 SVDFISSEAELKDFLHSKYQL------KLDLLIALNQMVAHQPLRAQLSQHTKELLHILKDL--- 565
            .....|..|.|.:..|.:..|      ||.:|..|  .|..:.:..|:..|..:::..:...
Mouse   617 FTPKPSCYASLLELEHHQTLLIEDQERKLQVLQLL--AVLCEKMSEQIFTHVTQVVDFVAATLQR 679

  Fly   566 ----LVHRSREQDTTDQILLLVLNLLQEILEGSENIQLSEACKELKEQLHLLGTRSSN----PLI 622
                |.|.: |.....|.|.:.:.|:..:|.|:..::.|:.. .||:.|.|| .|.||    |:|
Mouse   680 ACAGLAHEA-ESAVGSQTLSMSMGLVAVMLGGAVQLKSSDFA-VLKQLLPLL-ERVSNTYPDPVI 741

  Fly   623 QQSVKSL-LTI-IHGAW------------------------------------------------ 637
            |:....| :|| .|||:
Mouse   742 QELAADLRITISTHGAFSTDAVSTAAQSTLNQKDPGQKIEEQRQTSPDISTEGAQKPPRTGQGSS 806

  Fly   638 -------RPSEAVKIQPFQRARSLIEEKQSHMQVYGIQMMIDLLKKRDPATLAQGQLIIALALTT 695
                   :|..::..|.|:.......:.:...:...::.:...:::|:...|.:.:.::.:.|..
Mouse   807 GPCTATSQPPGSITTQQFREVLLSACDPEVPTRAAALRTLARWVEQREARALEEQKKLLQIFLEN 871

  Fly   696 LKDKESYTFLNCVRLFVSLVHVMESDVL-------DKLSDEYLSETAHLDYRLVVGEAILKVAQE 753
            |:.::|:.:|:.::....|..|...::|       |...|::..||     |:.|||.:::|.:.
Mouse   872 LEHEDSFVYLSAIQGIALLSDVYPEEILVDLLAKYDSGKDKHTPET-----RMKVGEVLMRVVRA 931

  Fly   754 LGPLCFRYKAVLLNCFMYGSRSPVHEFRMSAFANLAQLCRLLAFQVQNFFHELLQLVNSELTTGG 818
            ||.:..:|:..|::.|:.|.|.|....|.|:.|||.:||:.|.|.:....||:...:.:...|..
Mouse   932 LGDMVSKYREPLIHTFLRGVRDPDAAHRASSLANLGELCQCLHFLLGPVVHEVTACLIAVAKTDN 996

  Fly   819 YVPSKRAAVLVLAELLNGM-----ENLLDYQEMLLPIYRLLKAIEADESCDPQMRQHAANGLKIL 878
            .|..:||||.|:..||.|:     |.|.|   :|..:|.|||.:...|. |...:.||
Mouse   997 DVQVRRAAVHVVVLLLRGLSQKATEVLSD---VLRDLYHLLKHVVRLEP-DDVAKLHA------- 1050

  Fly   879 NKKCTKLIQSALEE------------KSLQKQIKVL 902
                    |.||||            :.|:|:|.||
Mouse  1051 --------QLALEELDEIMRNFLFPPQKLEKKIVVL 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango6	NP_609922.2	RTP1_C1	648..757	CDD:463059	21/115 (18%)
		RTP1_C2	846..879	CDD:431206	9/32 (28%)
Tango6	NP_766625.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..818		7/50 (14%)
		RTP1_C1	824..935	CDD:463059	36/110 (33%)
		HEAT 1	864..902		14/37 (38%)
		HEAT 2	937..973		12/40 (30%)
		RTP1_C2	1026..1059	CDD:431206