Protein Alignment Tango6 and ekl-6

DIOPT Version :10

• Sequence 1: NP_609922.2
• Gene: Tango6 / 35155
• FlyBaseID: FBgn0032728
• Length: 921
• Species: Drosophila melanogaster
• Sequence 2: NP_499234.2
• Gene: ekl-6 / 176419
• WormBaseID: WBGene00011806
• Length: 964
• Species: Caenorhabditis elegans
• Alignment Length: 917
• Identity: 177/917 - (19%)
• Similarity: 312/917 - (34%)
• Gaps: 286/917 - (31%)

  Fly   144 GKIKANFSLMLLSIQFFINLLHIRQYHIANSMELV---QRDLLAAIVSLRVQQ----DSPLLDK- 200
            |:....|...:|:::|.:..|.|.:|.: |..|||   |.|:|...:....|.    .:|:..|
 Worm   173 GQFLTKFIDDVLAVRFQLLQLKIDKYEL-NFAELVSKLQIDVLFGSLMFLTQDKKTAKTPMWLKV 236

  Fly   201 --------------AIAYLWQY--ESKADFFR-NILLFKATT-------------------LCPT 229
                          .::||.||  |...|.:. |:.|.|..:                   :...
 Worm   237 ACGKQMTKILVGKDGLSYLLQYYRERAGDTWTDNLPLTKQVSWHLATVPKMFRHPLNYHEIISNQ 301

  Fly   230 LAQLLHRQLLGKLHLPQGFASLVEALHQNPNVNSSRNAEIVASIVARKGFSQL----AQEKMVL- 289
            ..:||..|.:.:.:....|.:.||.||....:|:  |..:...|:   .|.::    .|:|.|:
 Worm   302 FFELLWSQKIPEQNTLNVFINYVEELHTRFALNA--NLTVFDKIL---NFWEVLDKKIQDKTVMH 361

  Fly   290 --QVLEYCKFYLQNADKMCAGVLSLRRLYDLSDTNQKLIKEILFKHWETLCNPEDIINGLILMDH 352
              :|..|...:::|...:....||.    |:..|  :.:...||...|.:...:||:.
 Worm   362 SEKVENYSPNFIRNLQLLSQLQLSA----DVKRT--RALSTCLFACVEQIPYIKDILK------- 413

  Fly   353 QELCNRILLWQHLFCSSTVACLPSNLLVPYLPLLLQLYD---------GLPMELPASSQISAIIL 408
                               :.|.|.|.:.|:     :|.         .|..:...||:|..|
 Worm   414 -------------------SALDSVLSIGYI-----IYQFVMTPSHRVALEKKFVTSSKIQEI-- 452

  Fly   409 RCLDNREMKNELPAILQKLFKWEIEKEPPWKCLNPRIIILPSMNTT-QIQ-------------VK 459
               ......|:.|.....|...|...|...:.|.....::.::.|: ||:             :|
 Worm   453 ---GGDSNGNDTPFDEMWLHGIESTDEGVARRLETAFFVIDNVLTSAQIRPILEMMNMALDDFLK 514

  Fly   460 VAHKDHLADHDMGRI--LPGL-LTSSSH-HSLTCKVFLSLL------GF----------IAKQI- 503
            |:.|:.  :.|..|.  |.|. |.|||| |.:....|..::      ||          ||:.|
 Worm   515 VSEKER--EDDQARFVQLDGAKLFSSSHAHLVVGACFERIINLAQDSGFSQEECVQLLRIAESIL 577

  Fly   504 -----------NDKSSASVDFISSEAELKDFLHSKYQLKLDL-LIALNQMVAHQPLRAQ------ 550
                       |.|.:..| |..:..|.|:|..|:...|:.| :|:...|:.....|..
 Worm   578 NNCTGKFMRMANRKRNVDV-FRMTPTEKKEFECSRDSAKMCLPMISTVFMLTQTTTRMHDVHIRS 641

  Fly   551 ---LSQHTK-----------------ELLHILKDLLVHRSREQDTTDQILLLVLNLLQEILEGSE 595
               ::..||                 |...:|:||.:..::....|          |.:..:...
 Worm   642 MEAMANFTKAADAFPSEDVSFNLAVDEAKKLLRDLKIDVNQVNAPT----------LPQRTDRQR 696

  Fly   596 NIQLSEACKELKEQLHLLGTRSSNPLIQQSVKSLLTIIHGAWRPSEAVKIQPFQRARSLIEEKQS 660
            ..|..:.|.|..|:||     ...|                     |:|.....:...:...:..
 Worm   697 YNQQVDVCNEWIEELH-----DDEP---------------------AIKGGALMQIARVFRNRTY 735

  Fly   661 HMQ---VYGIQMMIDLLKKRDPATLAQGQLIIALALTTLKDKESYTFLNCVRLFVSL----VHVM 718
            |.|   .||:   .|.:|                  ..:.|.:||.:|:.:.....:    .::.
 Worm   736 HCQRLFEYGV---FDAVK------------------DMVADDDSYVYLSAINCLCEMGLYNKNMF 779

  Fly   719 ESDVLDKLSDEYLSETAH---LDYRLV-----VGEAILKVAQELGPLCFRYKAVLLNCFMYGSRS 775
            |..:      ||..|.::   .|.:::     |.|||.|:....|.:...|...|...||.|...
 Worm   780 EDTI------EYYEEMSNQPQKDTKMIIRVGRVAEAIGKLLLARGEISVTYFDRLATLFMKGIDE 838

  Fly   776 PVHEFRMS---AFANLAQLCRLLAFQ--VQNFFHELLQLVNSELTTGGYVPSKRAAVLVLAELLN 835
            |....|.|   ||.||....|....:  :...||:::.::..:.:.   :..:.||.|:...|.:
 Worm   839 PEEILRASSCGAFGNLMIATRGRGSEKWLGQVFHKIVNIIRVDRSP---LVRRSAADLIRHSLQS 900

  Fly   836 -GMENLLDYQEMLLPIYRLLKAIEADESCDPQMRQHAANGLKILNKKCTKLIQSALE------EK 893
             |.:.|...:|.||.::|.::.:...:. |..:|.||        :.|.:.|::||.      |:
 Worm   901 TGRDMLAILREHLLDLHREIRQLHRTDR-DETVRLHA--------QLCLEEIEAALRQNQEDTER 956

  Fly   894 SLQKQIK 900
            ...::|:
 Worm   957 GYHRRIR 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango6	NP_609922.2	RTP1_C1	648..757	CDD:463059	21/123 (17%)
		RTP1_C2	846..879	CDD:431206	7/32 (22%)
ekl-6	NP_499234.2	RTP1_C1	704..819	CDD:463059	28/167 (17%)
		HEAT repeat	748..771	CDD:293787	5/40 (13%)
		HEAT repeat	781..816	CDD:293787	9/40 (23%)
		HEAT repeat	827..853	CDD:293787	9/25 (36%)
		HEAT repeat	867..894	CDD:293787	4/29 (14%)
		RTP1_C2	912..945	CDD:431206	9/41 (22%)