DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nak and AKL1

DIOPT Version :9

Sequence 1:	NP_477165.1	Gene:	Nak / 35154	FlyBaseID:	FBgn0015772	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_009615.1	Gene:	AKL1 / 852351	SGDID:	S000000263	Length:	1108	Species:	Saccharomyces cerevisiae

Alignment Length:	1529	Identity:	322/1529 - (21%)
Similarity:	512/1529 - (33%)	Gaps:	527/1529 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GKVFTVGRVTVTVEDVLAEGGFAMV----FLARGNGGGSSSATKY------ALKRMYVNNEHDLN 90
            |.:..||...|.|.:.|||||||.:    ||...|...::::...      .|||:.|.:|:.||
Yeast    25 GHIVCVGTHKVEVVNYLAEGGFAQIYVVKFLEYLNEFDNTASVPLKIGDVACLKRVLVQDENGLN 89

  Fly    91 VAKREIQIASNLSGHKNIIGYVDSSITPTGNGV--CEVLLLMPYCKH-HMLAMMNARLHVGFTEP 152
            ..:.|:::...|.|..||:.|.||:.:...:||  .||||||..|.: .:|..||.||....||.
Yeast    90 EMRNEVEVMKKLKGAPNIVQYFDSNASRRRDGVQGFEVLLLMELCPNKSLLDYMNQRLSTKLTEA 154

  Fly   153 EVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTDAGNFVLCDFGS-ATAKTLNPQQHGVTVV 216
            |::.|..|:|.::|::||....:||||:|:||:|.....||.|.|||| :|...:......:.::
Yeast   155 EIVKIMYDVALSISQMHYLPVSLIHRDIKIENVLVDAKNNFKLADFGSTSTCFPIVTTHQDIALL 219

  Fly   217 QEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPFGESTLAIQNGQFSIPD 281
            .:.|..:||..||:|||||||....|..|:||||||..||||.||:.|| |.|     |||:|..
Yeast   220 TQNIYVHTTPQYRSPEMIDLYRCLPINEKSDIWALGVFLYKLLFFTTPF-EMT-----GQFAILH 278

  Fly   282 S------SKYSKGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNPVQNLHKTPIPNFDLLVV 340
            |      :|||..:..||..||..:...||||:||.               .|...|.|.::.:.
Yeast   279 SKYEFPVNKYSSKLINLIIIMLAENPNLRPNIYQVL---------------YHLCEILNVEVPIE 328

  Fly   341 PPFESEAKRISAAASKAAKAQNVSVVEAGTSVAPRSRPKGSSSVHGGNPLGLGLPPSPSPRQNIT 405
            ..:...|...|.......|.|||.:         :........:...|.|.       ...:|:.
Yeast   329 DKYAEGAYNFSKYTQFQNKLQNVQL---------QMYQLQQKKIMQNNKLS-------DSEENLL 377

  Fly   406 SPQPQPQPVVEQFQANFPAMPPAVPPPPQAVTPAAPAASKLFESSGYPDPFN----EPAAAVIPT 466
            :         :.|.::|                  ..:|||        |.|    ..|.:.||:
Yeast   378 N---------DMFLSSF------------------EISSKL--------PMNASDGHAAVSRIPS 407

  Fly   467 EFLPAAEEPNKEEVPQDLNVIAGTPTKSMLTPPKPSGGGGHRRNVSDTSAFNKTFANETSQFLAP 531
            :.:....|..||.        .....||.|:..|.|                :|.:|..|
Yeast   408 QNVGQELEEEKES--------QSDQRKSTLSEDKSS----------------RTTSNANS----- 443

  Fly   532 FNNNLAAMGDGQQTLASAASNPGIYASSTANSAAVSISELMKPGQTAVEKRVEAWNPFEEEQPFS 596
                                      |.|||:.. .|:.:..||       :|..:.||.:.|
Yeast   444 --------------------------SGTANNPQ-EINTIQSPG-------IEDKSIFENKTP-- 472

  Fly   597 QMTEDHIFEAEFDKIRQRGSQGSITAKSASTTSTLTPTEQIPSAVVAPVTAAPGAVPPPPIAAAV 661
                                 |.:...|.|...|....|.:..:             ..|..:..
Yeast   473 ---------------------GELYYPSVSELDTYLDKELVKQS-------------SDPTISEQ 503

  Fly   662 SPYPSQVSEDPFGSAPFSLPPGLREKASSLRKTGAKFIGVSSGGTGGGVATPIGLVAGGANTATS 726
            ||..:..          |||.  |:|::|...:|    |.|...|..|.|| ||
Yeast   504 SPRLNTQ----------SLPQ--RQKSTSSYSSG----GRSMKSTSYGAAT-IG----------- 540

  Fly   727 SNSSKWMLSPTLEVSSEEKTSLISKLKTDSECGIPGAVGGAGEGVSGYVKLPVEDRNKYEKLRSK 791
                      :.|..:.|||:.|:|:|..                        :..|.:.|:...
Yeast   541 ----------SDEALANEKTAGINKMKQH------------------------KSNNPFPKMNVA 571

  Fly   792 DQPTSDDSDSEASEFFQQDSDEGGGGIFRQMQMVTSNLPETIHKIQQVAYHKVDKTAHLPIVKKL 856
            ...|::.| ::||.||.::..:|..  ::|.|..|.....|.          .|::.:...|::.
Yeast   572 YHSTNELS-NDASNFFLEEQQQGQR--YQQAQNQTGTQGNTF----------PDESQYQSRVEQQ 623

  Fly   857 RDKTKKPTTAAHQAAQQLNLMAAAVAAQAEEAAKAAESDGDSIGSASDLRAEDDDLFDENPRQTQ 921
            :.:..:|...|:.:  |.|....     .:.:.|..:..|...|.:.:.|....::.......:|
Yeast   624 QQQQDQPKGPANYS--QRNFYTG-----RDRSNKPMQLGGTIAGDSGNRRVNFQNISQNYATNSQ 681

  Fly   922 A----KQRRP-LPTEMDGISESVKTCSSSAYHAECESVTTHEDDVRSRVVVKVRMRKKDRALV-- 979
            :    .|..| :|.....||.:    ...|...:.:.:...:...:.::..|.:|:.:.:..|
Yeast   682 SGYLPSQNSPAIPMVRPVISMN----QQQAQQIQAQQLQAQQMQAKQQMQAKQQMQVQQQLQVQQ 742

  Fly   980 -----TATGDPSAPSEELSPTSSDLLHKFGDRPLLLDDELDYGSGESKSSTESPVAPILPTNPDV 1039
                 .|..:.:..|:..:.|:.|:.:..|..|                       |||..|
Yeast   743 QMQIQNANNNGTYVSDRTNHTTEDMRNAQGGEP-----------------------PILAGN--- 781

  Fly  1040 QESEEDVFALAPFKLPVGVPLKRKTKPKAKPKPSEPEMWTSTPVKSAAVGDPSTNFASFPAQLTP 1104
                                           ..:|| |.:|:.
Yeast   782 -------------------------------SANEP-MHSSSK---------------------- 792

  Fly  1105 TNNVGNSAQLDEFNEPIFNPFQENAQNTQSGETNQCDLFGLEPFPQVIRTIEQNPQHHQIHQFPS 1169
                 |.|.|.|     .:|.:|:|......:||:....|:|. .....||:           .|
Yeast   793 -----NEALLIE-----LSPLKEDAGKQSFQDTNEPQTGGIED-AGGSGTIK-----------GS 835

  Fly  1170 HNNNNNVIKVP------------ASVSVALPASVPVSVSV-------------NSSAPQL---VT 1206
            :||.|.|:.:.            |:||....:|...|:..             |.|..:|   :.
Yeast   836 NNNRNGVLNLSLNEMDLSRDDTGAAVSSFSSSSSSASIQQAKLSGRKGSSKRNNYSTDELGDSMV 900

  Fly  1207 INHSIIIN-------KTPEPPMNYNNNNNNQTAKSSGTSSVYVNVPSFSSMSTSSCSINQPQSSP 1264
            .:.||.|:       ||.|....:|...:...|:||..|    ....|.|...||.|..||:.|
Yeast   901 SSESIDIDLDDARRGKTAERRPLHNERGHKDQARSSDAS----KSNQFKSKDFSSVSTRQPRQS- 960

  Fly  1265 AAVIPVQAPLPVPVPAPVSVPAVPVPIPAVVTHLRPLLPIADNAYVQISQDRCSDFTPDDEEEPV 1329
                           ..::...|.:..|.:....|                     ..:|...|
Yeast   961 ---------------LDLNFQEVNLSSPTLTQEHR---------------------NKNDSPAP- 988

  Fly  1330 VLRDADVVADGIGIPTPAKPKKEKSNLAVRVLP---GKLTQKVKGHSYKKVSAAALGSTSSLSSG 1391
                                   .|:.:.||.|   ..:|:..:..:..::|..:.|...:..:|
Yeast   989 -----------------------NSHHSYRVSPHASTAITENKRHSTGHELSTRSNGKHETHRTG 1030

  Fly  1392 SKQKHQRLQYQSHDDDDDEQDQDENRGAGGGRNFQSNTIQNSAKTGFSNMSFEDFPSD--QEMDR 1454
            |||:|...:|:      ..:|:|.|         .|.||..|.            ||:  :...|
Yeast  1031 SKQRHDLERYR------HSKDKDSN---------SSITISTST------------PSEMRKSFAR 1068

  Fly  1455 LSRTIPFEVVRNEKMLLEAEKKFGSLKRRNNLFS 1488
            ..:::..|.||.|.|...|....||..:|.:.||
Yeast  1069 ARQSLDLERVRREAMASSASSSGGSNGKRRSFFS 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	115/296 (39%)
Nak	NP_477165.1	S_TKc	47..312	CDD:214567	113/284 (40%)
AKL1	NP_009615.1	STKc_NAK_like	31..322	CDD:270939	117/311 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346406
Domainoid	1	1.000	174	1.000	Domainoid score	I743
eggNOG	1	0.900	-	-		E1_KOG1989
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I813
Isobase	1	0.950	-	0	Normalized mean entropy	S2048
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001273
OrthoInspector	1	1.000	-	-		otm46860
orthoMCL	1	0.900	-	-		OOG6_101386
Panther	1	1.100	-	-	O	PTHR22967
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R972
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.820