DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nak and Gak

DIOPT Version :9

Sequence 1:NP_477165.1 Gene:Nak / 35154 FlyBaseID:FBgn0015772 Length:1488 Species:Drosophila melanogaster
Sequence 2:NP_112292.1 Gene:Gak / 81659 RGDID:621589 Length:1305 Species:Rattus norvegicus


Alignment Length:1584 Identity:338/1584 - (21%)
Similarity:529/1584 - (33%) Gaps:544/1584 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 PNSSSSSSSNEKNSFVGKVFTVGRVTVTVEDVLAEGGFAMVFLARGNGGGSSSATKYALKRMYVN 84
            |.|...::..:::.|||:...:|.:.:.|..||||||||.|:.|:..|.|    .:|||||:..|
  Rat    14 PGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDLGSG----REYALKRLLSN 74

  Fly    85 NEHDLNVAKREIQIASNLSGHKNIIGYVDSSI---TPTGNGVCEVLLLMPYCKHHMLAMMNARLH 146
            .|.......:|:.....||||.||:.:..::.   ..:..|..|.|||...||..::..:.   .
  Rat    75 EEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLR---R 136

  Fly   147 VGFTEP----EVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTDAGNFVLCDFGSATAKTLN 207
            |....|    .:|.||.....||..:|..:.|||||||||||:|.::.|...||||||||..:..
  Rat   137 VECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHY 201

  Fly   208 P------QQHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPFG 266
            |      |:.  .:|:|||.:.||..||.||::|||....|..|.|||||||:||.|||...||.
  Rat   202 PDYSWSAQKR--AMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE 264

  Fly   267 E-STLAIQNGQFSIP-DSSKYSKGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNPVQNLHK 329
            : :.|.|.||::||| :.::|:. .|.||:.||:.:.|:|.:|.:|..                 
  Rat   265 DGAKLRIVNGKYSIPVNDTRYTV-FHDLIRGMLKVNPEERLSIAEVVR----------------- 311

  Fly   330 TPIPNFDLLVVPPFESEAKRISAAASKAAKAQNVSVVEA----GTSVAPRSRPKGSSSVHGGNPL 390
                            :.:.|:||.:...||....::|.    |.|...|::|.....|:....|
  Rat   312 ----------------QLQEIAAARNVNPKAPITELLEQNGGYGNSGPSRAQPPSGGPVNSSGVL 360

  Fly   391 GLGLPPSP----------SPRQNITSPQPQPQPVVEQFQANFPAMPPAVPPPPQAVTPAAPAASK 445
            .|.....|          ...:..|:.:.....|: |..||:          .:.....:...|:
  Rat   361 ALAEYDQPYGGFLDILRGGTERLFTNLKDTSSKVI-QSVANY----------AKGDLDISYITSR 414

  Fly   446 LFESSGYPDPFNEPAAAVIPTEFLPAAEEPNKEEVPQDLNV-IAGTPTKSMLTPPKPSGGGGHRR 509
            :             |....|.|.:.:|.:.|.|:|...|:. ..|......|:|........|.|
  Rat   415 I-------------AVMSFPAEGVESAIKNNIEDVRLFLDAKHPGHYAVYNLSPRIYRASKFHNR 466

  Fly   510 NVSDTSAFNK--------TFANETSQFLAPFNNNLAAMG--DGQQTLASAASNPGIYA------- 557
            ......|..:        |.......:|...:.|:..:.  ||:     |||...:.|       
  Rat   467 VTECGWAVRRAPHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGR-----AASAVAVCAFLCFCRL 526

  Fly   558 SSTANSAAVSISELMK---PGQTAVEKR-VEAWNPFEEEQPFSQ-----------MTEDHIF--- 604
            .|||.:|....|  ||   ||.....|| :|.......|:|.:.           ||...:|   
  Rat   527 FSTAEAAVYMFS--MKRCPPGIWPSHKRYIEYVCDMVAEEPITPHSKPMLVKSVVMTPVPLFSKQ 589

  Fly   605 --------------------EAEFDKIR----QRGS---------QGSITAKSASTTSTLTPTEQ 636
                                ..|:|:::    :.|.         ||.:........|||....|
  Rat   590 RNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKAVIPLGITVQGDVLTIIYHARSTLGGRLQ 654

  Fly   637 --IPSAVVAPVTAAPGAVPPPPIAAAVSPYPSQVSEDPFGSAPFSLPPGLREKASSLRKTGAKFI 699
              :.|..:..:....|.||........:.|.....:             ::||...|.:...: :
  Rat   655 AKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACD-------------IQEKYPDLFQVNLE-V 705

  Fly   700 GVSSGGTGGGVATPIGLVAGGANTATSSNSSKWMLSPTLEVSSEEKTSLISKL------------ 752
            .|....      .|...|....||:....:.|.:.|     :.||:..::||.            
  Rat   706 EVEPRD------RPSRDVPPWENTSLRGLNPKILFS-----NREEQQDILSKFGKPELPRQPGST 759

  Fly   753 -KTDSECGIPGAVGGAGEGVSGYVKLPVEDRNKYEKLRSKDQPTSDDSDSEASEF-----FQQDS 811
             :.|:|.|.|.|                       ::...|.|.|..:|:  :.|     :|::.
  Rat   760 AQYDAEAGSPEA-----------------------EITESDSPQSSSTDT--NHFLHTLDWQEEK 799

  Fly   812 DEGGGGIFRQMQMVTSNLPETIHKIQQVAYHKVDKTAHLPIVKKLRDKTKKPTTAAHQAAQQLNL 876
            |                 |||          .||.|:                    ....|.||
  Rat   800 D-----------------PET----------GVDNTS--------------------PKESQSNL 817

  Fly   877 MAAAVAAQAEEAAKAAESDGDSIGSASDLRAEDDDLFDENPRQTQAKQRRPLPTEMDGISESVKT 941
            :|                |||  ||         ::.||......:::|:|      |..|....
  Rat   818 IA----------------DGD--GS---------EVSDEEEASCPSEERKP------GAGEDTPR 849

  Fly   942 CSSSAYHAECESVTTHEDDVRSRVVVKVRMRKKDRALVTATGDPSAPSEELSPTSS-DL--LHKF 1003
            .::..                         |::|  |:...|..:||.|.:.|... ||  ||..
  Rat   850 LAAGT-------------------------RQQD--LIFDVGMLAAPQEPVQPEEGVDLLGLHSE 887

  Fly  1004 GD-RPL--------------LLDDEL------------DYGSGESKSSTESPVAPILPTNPDVQE 1041
            || ||.              ||...|            |...||:.....|||: :|....::|.
  Rat   888 GDLRPAAPLQASGVQSSNTDLLSSLLEPSDASQVGPPGDLLGGETPLLLASPVS-LLGVQSNLQG 951

  Fly  1042 SEEDVFALAPFKLPVGVPLKRKTKPKAKPKPSEPEMWTSTPVKSAAVGDPSTNFASFPAQLT--- 1103
            ...|  .:.||...: :|....|:|.:||......:.:.:...|.|.  |||:.|..|:..|   
  Rat   952 KVPD--TVDPFDQFL-LPSSSDTQPCSKPDLFGEFLNSDSVASSTAF--PSTHSAPPPSCSTAFL 1011

  Fly  1104 --------PTNNVGNSAQLD-----------EFNEPIFNPFQENAQNTQSGETNQCDLFGLEPFP 1149
                    |...:.:|:..|           ....|...|..|....:.:|..       ..|.|
  Rat  1012 HLGDLPAEPNKVIASSSHPDLLGGWDTWAETALPGPASMPVPEGTLFSSAGHP-------APPGP 1069

  Fly  1150 QVIRTIEQNPQHHQIHQFPSHNNNNNVIKVPASVSVALPASVPVSVSVNSSAPQLVTINHSIIIN 1214
            ...:|..|||.     .|...::.::.::       .|||.:|....|.:||             
  Rat  1070 NPSQTKSQNPD-----PFADLSDLSSSLQ-------GLPAGLPAGSFVGTSA------------- 1109

  Fly  1215 KTPEPPMNYNNNNNNQTAK--SSGTSSVYVNVPSFSSMSTSSCSINQPQSSPA-----------A 1266
                  ..:.:|::.||.:  :.|||.                   .||:.||           :
  Rat  1110 ------TTHKSNSSWQTTRPTAPGTSW-------------------PPQAKPAPRASEQLRSHFS 1149

  Fly  1267 VIPVQAPLPVPVPAPVSVPAVPVPIPAVVTHLRPLLPIADNAYVQISQDRCSDFTPDDEEEPVVL 1331
            ||..:....|..|:....|.|                 ::|.:..:..::  .|:..|::.|..:
  Rat  1150 VIGAREERGVRAPSFAQKPKV-----------------SENDFEDLLPNQ--GFSKSDKKGPKTM 1195

  Fly  1332 ---------RDAD--------------------------VVADG---------IGIPTPAKPKKE 1352
                     ||.|                          |:.||         ..:.||.:.||:
  Rat  1196 AEMRKQELARDTDPFKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVSMADLVTPEQVKKQ 1260

  Fly  1353 KSNLAVRVLPGKLTQKVKGHSYKK 1376
            .....:.|.|.|.|    |..|::
  Rat  1261 YRRAVLVVHPDKAT----GQPYEQ 1280

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NakNP_477165.1 STKc_NAK_like 42..319 CDD:270939 112/291 (38%)
S_TKc 47..312 CDD:214567 111/279 (40%)
GakNP_112292.1 STKc_GAK 39..320 CDD:270938 113/323 (35%)
S_TKc 41..311 CDD:214567 111/279 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..354 5/21 (24%)
PTEN_C2 568..706 CDD:287393 20/151 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 747..856 33/238 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1044..1141 28/153 (18%)
DnaJ <1253..1298 CDD:99751 10/32 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1989
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D296562at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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