DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nak and dnajc6

DIOPT Version :9

Sequence 1:	NP_477165.1	Gene:	Nak / 35154	FlyBaseID:	FBgn0015772	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	XP_021332834.1	Gene:	dnajc6 / 796345	ZFINID:	ZDB-GENE-080104-2	Length:	979	Species:	Danio rerio

Alignment Length:	881	Identity:	168/881 - (19%)
Similarity:	287/881 - (32%)	Gaps:	289/881 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KFERNENSRLENPPNSSSSSSSNEKNSFV-GKV---FTVGRVTV------TVE------------ 49
            ||..|....|::....:|:...|:..::. |::   :...|:.|      |||
Zfish    91 KFFSNIKDNLKDTIKDTSTKVMNQVATYTKGELDIAYITSRIIVMSYPAETVEMGYRNHTEDIRS 155

  Fly    50 --DVLAEGGFAMVFLARGNGGGSSSATKYALKRMYVNNEHDLNVAKREIQIASNL-SGHKNIIGY 111
              |......:.:..|::.|..|:.          :.|...:.|...|:.....|| :..||:..:
Zfish   156 FLDSRHADHYTVFNLSQRNYRGAK----------FSNRVSECNWPSRQAPSLHNLFAVCKNMYNW 210

  Fly   112 VDSS------IT------PTGNGVCEVLLLMPYCKHHMLA-------MMNA-----------RLH 146
            :..:      ||      |:|..||.:     :|..|:.|       :::|           |.:
Zfish   211 LKQNPKNVCVITCSDGRAPSGVLVCAM-----FCFCHLFANPVPAMQLLSAKRPGSGLWPSHRRY 270

  Fly   147 VGFTEPEVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENI---LQTDAGNFVLCDFGSATAKTLNP 208
            :|:.        |.:......:.:.: |::.:.:.:..:   .:..:|....||......|..:.
Zfish   271 IGYV--------CSLVSEKPTVPHSK-PLVIKTVTISPVPCFNKQRSGCRPFCDVLIGETKIFST 326

  Fly   209 QQHGVTVVQEEIQKYTT-----LSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCF---FSLPF 265
            .|....:.:..||:...     :|.:...:|.:|..:|...:|.:  ....::::.|   |..|
Zfish   327 AQEYERMREHRIQEGKVVFPVGVSAQGDVVISVYHMRSHALQAKV--TNTQIFQIQFHTGFIAP- 388

  Fly   266 GESTLAIQNGQFSIPDS-SKYSKGMHQLIKYMLE---------------PDMEKRPNIWQVCE-- 312
            |.:.|.....:....|| .||.:..|.||...:|               |..:..||:...|.
Zfish   389 GSTVLKFMKTELDACDSPEKYPQLFHVLIDIEVESTEKQKDLTPPWEQFPTKDLSPNVLFSCHQE 453

  Fly   313 ------VAFRLAGKD--NPVQNLHKT----------PIPNFDLLVVPPFESEAKRISAAASKAAK 359
                  :|..:.|.|  :|.|. |.:          ..|:.|.::  ...|:....|...|||||
Zfish   454 HQDALAIADEMEGLDLEDPAQG-HSSCGGRVGPNEESEPSDDEML--SLSSQQSNASNEKSKAAK 515

  Fly   360 -------------AQNVSV--VEAGTSVAPRSRPKGSSSVHGGNPLG--LGLPPSP--------- 398
                         |:.|.:  ::...:..|.|.|:..::....:.||  .|.||:|
Zfish   516 RPEPQAAAPPPPAAEEVDLLGLDGDAAKIPPSSPQPPANNTTTDLLGDLFGAPPTPQPASCPGSA 580

  Fly   399 --SPRQNITSPQPQPQP----VVEQFQANFPAMPPAVPPPPQAVTPAAPAASKLFESSGYPDPFN 457
              :||::..|..|.|.|    ..:.|.:.     ||..|.||....|......:    |.|||
Zfish   581 QSTPRRSAQSSSPGPSPRSGNTFDPFGSG-----PAPAPKPQDFMGAFLGPGNM----GQPDP-- 634

  Fly   458 EPAAAVIPTEFLPAAEEPNKEEVPQDLNVIAG--------TPTKSM----------LTPPKPSGG 504
                      ||.||..|:    |...|:..|        |||.::          ...|..:||
Zfish   635 ----------FLHAARSPS----PTMQNMGMGRSSPVPPSTPTVNIQQQNSTGAWEWNKPAAAGG 685

  Fly   505 ----GGHRRNVSDTSAFNKTFANETS-QFLAPFNN--NL-AAMGDGQQTLASAASNPGIYASSTA 561
                |....:.|.||:.:.|..::|. ..|.||.:  || |.:|.|....:|..:.|     :..
Zfish   686 GFGMGSKSASTSPTSSAHGTPTHQTKPNTLDPFADLGNLGAGLGGGGSGFSSKPTTP-----TGT 745

  Fly   562 NSAAVSISELMKPGQTAVEKRVEAWNPFEEEQPFSQMTEDHIFEAEFDKIRQRGSQGSITAKSAS 626
            ..|...:....:|..:........|:|
Zfish   746 GGAFPPMGSPQRPAPSPQHTASGGWHP-------------------------------------- 772

  Fly   627 TTSTLTPTEQI-------PSAVVAPVTAAPGAVPPPPIAAAVSP---------YPSQVSEDPFGS 675
              :|..|:.|.       |.|...|..|.|.::|      ..||         :.:.....|..:
Zfish   773 --NTGFPSWQAGGGAQWQPQAQGTPTKAPPASMP------HTSPQNRPNYNVSFSAMSGASPGAA 829

  Fly   676 APFSLP-PGLREKASSLRKTGAKFIGVSSG-GTGGG 709
            .|.:.| .|.|.|.|.     |.|..:.|| |..||
Zfish   830 GPKAQPNMGTRPKVSD-----ANFDDLLSGQGFAGG 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	60/362 (17%)
Nak	NP_477165.1	S_TKc	47..312	CDD:214567	56/336 (17%)
dnajc6	XP_021332834.1	PTEN_C2	285..420	CDD:313607	25/138 (18%)
		Atrophin-1	<538..842	CDD:331285	76/379 (20%)
		DnaJ	<927..968	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296562at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010