DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nak and Dnajc6

DIOPT Version :9

Sequence 1:	NP_477165.1	Gene:	Nak / 35154	FlyBaseID:	FBgn0015772	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_001158055.1	Gene:	Dnajc6 / 72685	MGIID:	1919935	Length:	968	Species:	Mus musculus

Alignment Length:	872	Identity:	174/872 - (19%)
Similarity:	269/872 - (30%)	Gaps:	321/872 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SRLENPPNSSSSSSSNEKNSFVGKVFTVGRVTVTVEDVLAEGGFAMVFLARGNGGGSSSATKYAL 78
            |....||:.:|::.|:            |..:..:|.....|.|.||   :|..|
Mouse    47 SPARQPPHRASTTDSS------------GASSPDMEPSYGGGLFDMV---KGGAG---------- 86

  Fly    79 KRMYVNNEHDL-----NVAKREIQIASNLSGHKNIIGYVDSSITPTG-----------NGVCEV- 126
             |::.|.:.:|     :.:.|.||..|:.:.......||.|.|....           |.|.::
Mouse    87 -RLFSNLKDNLKDTLKDTSSRVIQSVSSYTKGDLDFTYVTSRIIVMSFPVDSVDIGFRNQVDDIR 150

  Fly   127 -LLLMPYCKHHML------AMMNARLHVGFTE--------PEVLNIFCDIAEAVSRLHY---CQT 173
             .|...:..|:.:      :...|:.|...:|        |.:.|:|     ||.|..|   .|.
Mouse   151 SFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLF-----AVCRNMYNWLLQN 210

  Fly   174 PIIHRDLKVENILQTDAGN-------FVLCDFGSA---TAKTLNPQQHGVTVVQEEIQKYTTLSY 228
            |   :::.|.:.|...|.:       |:.|:..|.   ..:.|..::.|:.:.... ::|  |.|
Mouse   211 P---KNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSH-RRY--LGY 269

  Fly   229 RAPEMIDLYGG-------KSITTKA---------DIWALGCMLYKLCFFSLPFGESTL------- 270
                |.||...       |.:|.||         :....||..|  |  .:..||:.:
Mouse   270 ----MCDLLADKPYRPHFKPLTIKAITVSPVPFFNKQRNGCRPY--C--DVLIGETKIYSTCTDF 326

  Fly   271 ------AIQNGQFSIP-----------------------------DSSKYSKGMHQ--------L 292
                  .:|:|:..||                             ::..:....|.        :
Mouse   327 ERMKEYRVQDGKIFIPLNITVQGDVIVSMYHLRSTIGSRLQAKVTNTQIFQLQFHSGFIPLDTTV 391

  Fly   293 IKYMLEPDM------EKRPNIWQVCEVAFRLAGKDNPVQNLHKTPIPNFDLLVVPPFESE-AKRI 350
            :|: .:|::      ||.|.::||.        .|..||...|.    .||  .||:|.. .|.:
Mouse   392 LKF-TKPELDACDVPEKYPQLFQVT--------LDIEVQPQDKV----IDL--TPPWEHYCTKDV 441

  Fly   351 SAAASKAAKAQNVSVVEAGTSVAPRSRPKGSSSVHGGNPLGLG---------------------- 393
            :.:...:::.::...:..| ..||...|..    |..| ||.|
Mouse   442 NPSILFSSQQEHQDTLALG-GQAPADLPPD----HPRN-LGQGGFFASLCWQDQKSEKSRCEEDH 500

  Fly   394 --------------LPPSPSPRQNITSPQPQ--PQPVVEQFQANFPAMPPAVPPPPQAVTPAAPA 442
                          |....||..|....:|.  .:|..:|       ..||.||||:.|......
Mouse   501 AALVNQESEQSDDELLTLSSPHGNAEGDKPHGAKKPGKKQ-------QEPAAPPPPEEVDLLGLE 558

  Fly   443 ASKLFESSGYPDPFNEPAAAVIPTEFLPAAEEPNKEEVPQDL--NVIAGTPTKS-------MLTP 498
            .|.                  :.|.|...|..|:..|:..||  .|.|..|.::       :..|
Mouse   559 GSD------------------VSTNFSSLAAPPSNSELLSDLFGGVGATGPAQAGQAGVEDVFHP 605

  Fly   499 PKP-SGGGGHRRNVSDTSAFNKTFANETSQFLAPFNNNLAAMGDGQQTL------ASAAS----- 551
            ..| |.....||..:..||.......|.:.| .||  ...|...||..|      :||:|
Mouse   606 SGPVSAQSTPRRTATSASASPTLRVGEGATF-DPF--GAPAKPPGQDLLGSFLNTSSASSDPFLQ 667

  Fly   552 -----NPGIYASSTANSAAVSISELM--------KPGQTAVEKRVEAWNPFEEEQPFSQMTEDHI 603
                 :|.::||||   .||:|...:        |||...:..:..|.:|...    |..|..|.
Mouse   668 PTRSPSPTVHASST---PAVNIQPDIAGGWDWHTKPGGFGMGSKSAATSPTGS----SHGTPTHQ 725

  Fly   604 FEAE-FDKIRQRGSQGSITAKSASTTSTLTPTEQIPSAVVAPVTAAPGAVPPPPIAAAVSPYP-- 665
            .:.: .|.....|:.||.:..|..||.                |...|..||.......||.|
Mouse   726 SKPQTLDPFADLGTLGSSSFASKPTTP----------------TGLGGGFPPLSSPQKASPQPMG 774

  Fly   666 -----------SQVSEDPFGSAPFSLP 681
                       .|....|..|.|.|.|
Mouse   775 GGWQQPAGYNWQQTQSKPQSSMPHSSP 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	71/393 (18%)
Nak	NP_477165.1	S_TKc	47..312	CDD:214567	70/381 (18%)
Dnajc6	NP_001158055.1	PTEN_C2	281..419	CDD:287393	23/150 (15%)
Dnajc6	NP_001158055.1	DnaJ	<916..961	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296562at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010