DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nak and BMP2K

DIOPT Version :9

Sequence 1:	NP_477165.1	Gene:	Nak / 35154	FlyBaseID:	FBgn0015772	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_942595.1	Gene:	BMP2K / 55589	HGNCID:	18041	Length:	1161	Species:	Homo sapiens

Alignment Length:	1387	Identity:	392/1387 - (28%)
Similarity:	537/1387 - (38%)	Gaps:	492/1387 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SFVG-KVFTVGRVTVTVEDVLAEGGFAMVFLARGNGGGSSSATKYALKRMYVNNEHDLNVAKREI 96
            |.|| :||.|||..||:|:.||||||:.|||.|.:||     .:.|||||||||..||||.||||
Human    37 SSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGG-----IRCALKRMYVNNMPDLNVCKREI 96

  Fly    97 QIASNLSGHKNIIGYVDSSITPTGNGVCEVLLLMPYCK-HHMLAMMNARLHVGFTEPEVLNIFCD 160
            .|...|||||||:||:|.::....:.|.|||:||.||: ..::..||.:|..||||||||.||||
Human    97 TIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCD 161

  Fly   161 IAEAVSRLHYCQTPIIHRDLKVENILQTDAGNFVLCDFGSATAKTLNPQQHGVTVVQEEIQKYTT 225
            ..|||:|||.|:||||||||||||||..|.||:|||||||||.|.||||:.||.||:|||:||||
Human   162 TCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTT 226

  Fly   226 LSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPFGESTLAIQNGQFSIPDSSKYSKGMH 290
            |||||||||:|||||.||||||||||||:|||||||:||||||.:||.:|.|:|||:|:||:.:|
Human   227 LSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIH 291

  Fly   291 QLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNPVQNLHKTPIPNFDLLVVPPFESEAKRISAAAS 355
            .||::|||||.|.||:|:||...||:.|.||.||.|::.:.||:  .|..|...|||    ||..
Human   292 CLIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPS--ALPEPMTASEA----AARK 350

  Fly   356 KAAKAQNVSVV-EAGTSVAPRSRPKGSSSV--------------------------H-------- 385
            ...||:....: ...||:|||.|||.:|:.                          |
Human   351 SQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRP 415

  Fly   386 GGNP---LGLGLPPSP-------------------------SPRQNITSPQPQPQPVVEQFQA-- 420
            |..|   ||.|.|..|                         .|.|.....|.|.|...:|.|.
Human   416 GNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ 480

  Fly   421 -----------NFPAMPPAVPPPPQAVTPAAPAASKLFESSGYPDPFNEPAAAVIPTEFLP---- 470
                       :...:..|.....|..|.......:.|.......|  :|:|:..|| .:|
Human   481 QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQP--QPSASQYPT-MMPQYQQ 542

  Fly   471 --------AAEEPNKEEV-------PQDLNVIAGTPTKSMLTPPKPSGGGGHRRNVSDTS-AFNK 519
                    |..:|::::.       ||:.     :|.....|...|:..|    .:.|:| :.|:
Human   543 AFFQQQMLAQHQPSQQQASPEYLTSPQEF-----SPALVSYTSSLPAQVG----TIMDSSYSANR 598

  Fly   520 TFANETSQFLAPFNNNLAAMGDGQQTLASAASNPGIYASSTANSAAVSISELMKPGQTAVEKRVE 584
            :.|::  :.:|.|.|        |:.:    |||                           ..:.
Human   599 SVADK--EAIANFTN--------QKNI----SNP---------------------------PDMS 622

  Fly   585 AWNPFEEEQPFSQMTEDHIFEAEFDKIR-QRGSQGSITAKSASTTSTLTPTEQIPSAVVAPVTAA 648
            .||||.|:. ||::||:.:.:.|||.:| .|..:.:.:.|:..:.|                  |
Human   623 GWNPFGEDN-FSKLTEEELLDREFDLLRSNRLEERASSDKNVDSLS------------------A 668

  Fly   649 PGAVPPPPIAAAVSPYPSQVSEDPFGSAPFSLPPGLREKASSLRKTGAKFIGVSSGGTGGGVATP 713
            |...||               ||||||.||....|..||.:.          .||.....|.|.|
Human   669 PHNHPP---------------EDPFGSVPFISHSGSPEKKAE----------HSSINQENGTANP 708

  Fly   714 IGLVAGGANTATSSNSSKWMLSPTLEVSSEEKTSLISK-LKTDSECGIPGAVGGAGEGVSGYVKL 777
            |                           ...|||..|| .:|..:..:.|.|....:
Human   709 I---------------------------KNGKTSPASKDQRTGKKTSVQGQVQKGND-------- 738

  Fly   778 PVEDRNKYEKLRSKDQPTSDDSDSEASEFFQQDSDE---GGGGIFRQMQMVTSNLPETIHKIQQV 839
              |..:.:|    .|.|:...|:.|     :||.:|   |..|.|........||
Human   739 --ESESDFE----SDPPSPKSSEEE-----EQDDEEVLQGEQGDFNDDDTEPENL---------- 782

  Fly   840 AYHKVDKTAHLPIVKKLRDKTKKPTTAAHQAAQQLNLMAAAVAAQAEEAAKAAESDGDSI----- 899
                    .|.|::....|:.::...::....:|               |||..||..|:
Human   783 --------GHRPLLMDSEDEEEEEKHSSDSDYEQ---------------AKAKYSDMSSVYRDRS 824

  Fly   900 --GSASDLRA-------EDDDLFDENPRQTQAKQRRPLPTEMDGISESVKTCSSSAYHAECESVT 955
              |...||..       ...|:..|.|:|
Human   825 GSGPTQDLNTILLTSAQLSSDVAVETPKQ------------------------------------ 853

  Fly   956 THEDDVRSRV---VVKVRMRKKDRALVTATGDPSAPSEELSPTSSDLLHKFGDRPLLLDDELDYG 1017
              |.||...|   .|:.:..::::            :|:..|.     |:|
Human   854 --EFDVFGAVPFFAVRAQQPQQEK------------NEKNLPQ-----HRF-------------- 885

  Fly  1018 SGESKSSTESPVAPILPTNPDVQESEEDVFALAPFKLPVGVPLKRKTKPKAKPKPSEPEMWTSTP 1082
                      |.|       .:::.|.|||..|||...|.|.......|:|...|..|:
Human   886 ----------PAA-------GLEQEEFDVFTKAPFSKKVNVQECHAVGPEAHTIPGYPK------ 927

  Fly  1083 VKSAAVGDPSTNFASFPAQLTPTNNVGNSAQLDEFNEPIFNPFQENAQNTQSGETNQCDLFGLEP 1147
                                          .:|.|....|.||..:...::|.|    |||||.|
Human   928 ------------------------------SVDVFGSTPFQPFLTSTSKSESNE----DLFGLVP 958

  Fly  1148 FPQVIRTIEQNPQHHQIHQFPSH----------NNNNNVIKVPASVSVALPASVPVSVSVNSSAP 1202
            |.::..:.:|..:...:.:..|.          :|.......|.|....|..:.
Human   959 FDEITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTY----------- 1012

  Fly  1203 QLVTINHSIIINKTPEPPMNYNNNNNNQTAKSSGTSSVYVNVPSFSSMSTSSCSIN--------- 1258
                        :|||....:.......:..|:          .|.::|.|..:|:
Human  1013 ------------RTPERARRHKKVGRRDSQSSN----------EFLTISDSKENISVALTDGKDR 1055

  Fly  1259 ----QPQSS---PAAVIPVQAP 1273
                ||:.|   |....|..:|
Human  1056 GNVLQPEESLLDPFGAKPFHSP 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	182/277 (66%)
Nak	NP_477165.1	S_TKc	47..312	CDD:214567	177/265 (67%)
BMP2K	NP_942595.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		STKc_NAK_like	47..320	CDD:270939	182/277 (66%)
		S_TKc	52..311	CDD:214567	175/263 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..439		17/80 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..495		7/41 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..630		9/58 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..832		56/298 (19%)
		BMP2K_C	893..1161	CDD:291930	47/258 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	965..1035		10/102 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1137..1161
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I1000
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1675
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001273
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101386
Panther	1	1.100	-	-	LDO	PTHR22967
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R972
SonicParanoid	1	1.000	-	-		X882
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	8.080