Protein Alignment Nak and Aak1

DIOPT Version :9

• Sequence 1: NP_477165.1
• Gene: Nak / 35154
• FlyBaseID: FBgn0015772
• Length: 1488
• Species: Drosophila melanogaster
• Sequence 2: XP_017448306.1
• Gene: Aak1 / 500244
• RGDID: 1305520
• Length: 1306
• Species: Rattus norvegicus
• Alignment Length: 1558
• Identity: 442/1558 - (28%)
• Similarity: 621/1558 - (39%)
• Gaps: 458/1558 - (29%)

  Fly     1 MKKILSKFERNENSRLENPPNSSSSSSSNEKNSFVGKVFTVGRVTVTVEDVLAEGGFAMVFLARG 65
            |||.........:|.|.:..:....|||...:.::|:||.:||..|||::||||||||:|||.|
  Rat     1 MKKFFDSRREQGSSGLGSGSSGGGGSSSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVR- 64

  Fly    66 NGGGSSSATKYALKRMYVNNEHDLNVAKREIQIASNLSGHKNIIGYVDSSITPTGNG-VCEVLLL 129
                :|:..|.|||||:|||||||.|.||||||..:|||||||:||:||||....:| |.|||:|
  Rat    65 ----TSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLIL 125

  Fly   130 MPYCK-HHMLAMMNARLHVGFTEPEVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTDAGNF 193
            |.:|: ..::.:||.||..||||.|||.||||..|||:|||.|:||||||||||||||..|.|::
  Rat   126 MDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHY 190

  Fly   194 VLCDFGSATAKTLNPQQHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKL 258
            |||||||||.|..|||..||..|::||:||||||||||||::||.||.||||||||||||:||||
  Rat   191 VLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 255

  Fly   259 CFFSLPFGESTLAIQNGQFSIPDSSKYSKGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNP 323
            |:|:||||||.:||.:|.|:|||:|:||:.||.||:||||||.:|||:|:||...:|:|..|:.|
  Rat   256 CYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECP 320

  Fly   324 VQNLHKTPIPNFDLLVVPPFESEAKRISAAASKAAKAQNVSVVEAGTSVAPRSRPKGSSSVHGGN 388
            |.|:..:|||.  .|..|...||| .:.....||.....:...|  ||:|||.|||...:  ..|
  Rat   321 VPNVQNSPIPT--KLPEPVKASEA-AVKKTQPKARLTDPIPTTE--TSIAPRQRPKAGQT--QPN 378

  Fly   389 PLGLGLPPSPSPRQNIT---------------------------------------------SPQ 408
            |..|.:.|:.:||:..|                                             :||
  Rat   379 PGILPIQPALTPRKRATVQPLPQATGPSNQPSLLASVSQPKAQATPSQPLQSSQPKQPQAPPTPQ 443

  Fly   409 PQPQPVVEQFQANFPAMP-------------------------PAVPPPP--------------- 433
            ..|.|..:.......|.|                         |..||.|
  Rat   444 QTPAPQTQGLPTQAQATPQHQQQLLLKQQQQQQQQQQQQQPQQPTAPPQPSGTFYQQQQPQQQQA 508

  Fly   434 -----QAVTPAA--------PAASK-------------------------------LFESSG--Y 452
                 |||.|||        |..|:                               |.:.:.  .
  Rat   509 QTQQFQAVHPAAQQSVTAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQLMAQQAALQQKTAVVV 573

  Fly   453 PDPFNEP------AAAVIPTEF-LPAAEEPNKEEVPQDLNVIAGTPTKSMLTPPKP-SGGGGHRR 509
            |.|..:|      |||..|.:. .||.::|..:..|..  .|.|....|:..|..| :...||||
  Rat   574 PQPQAQPATAPQAAAAQEPAQIQAPARQQPKVQTTPPP--TIQGQKVGSLTPPSSPKTQRAGHRR 636

  Fly   510 NVSDTSAFNKTFANETSQFLAPFNNNLAAMGDGQQTLASAASNPGIYASSTANSAAVSISELMKP 574
            .:||.:        .::.|..|.:.:       .|.|.:||:...:   |.:.||..:.|...:.
  Rat   637 ILSDVT--------HSAVFGVPASKS-------TQLLHAAAAEASL---SKSKSATTTPSGSPRT 683

  Fly   575 GQTAVEKRVE--AWNPFEEEQPFSQMTEDHIFEAEFDKIRQRGSQGSITAKSASTTSTLTPTEQI 637
            .|..|....|  .||||:::. ||::|.:.:...:|.|:    .:|.:..|...:..:|.|..|
  Rat   684 SQQNVSNASEGSTWNPFDDDN-FSKLTAEELLNKDFAKL----GEGKLPEKLGGSAESLIPGFQ- 742

  Fly   638 PSAVVAPVTAAPGAVPPPPIAAAVSPYPSQVSEDPFGSAPFSLPPGLREKASSLRKTGAKFIGVS 702
                     |..|                    |.|.::.||.....:.|......:|...:.||
  Rat   743 ---------ATQG--------------------DAFATSSFSAGTAEKRKGGQAVDSGIPLLSVS 778

  Fly   703 SGGTGGGVA-TPIGLVAGGANTATSSNSSKWMLSPTL----EVSSEEKTSLISKLKTDSECGIPG 762
            .......|. .|..|:.|..:..||      :|.|.|    :.......::|.|.....|..|||
  Rat   779 DPFIPLQVPDAPEKLIEGLKSPDTS------LLLPDLLPMTDPFGSTSDAVIEKADAAVESLIPG 837

  Fly   763 AVGGAGEGVSGYVKLPVEDRNKYEKLRSKDQPTSDDSDSEASEFFQQDSDEGGGGIFRQMQMVTS 827
            ......:.:..:.:....:|.        |..|.:||..:.|......:|
  Rat   838 LEPPVAQRLPSHTESVTSNRT--------DSLTGEDSLLDCSLLSNPTAD--------------- 879

  Fly   828 NLPETIHKIQQVAYHKVDKTAHLPIVKKLRDKTKKPTTAAHQAAQQLNLMAAAVAAQAEEAAKAA 892
                           .:|:.|.:.:           :.:.|:||:..||::
  Rat   880 ---------------LLDEFAPIAL-----------SASTHKAAEDSNLIS-------------- 904

  Fly   893 ESDGDSIGSASDLRAEDDDLFDENP----RQTQAKQRRPLP---TEMDGISESVKTCSSSAYHAE 950
               |..:...|:..|||:  ||..|    :.||..||.|.|   ..::...|:|.|.....|...
  Rat   905 ---GFGVAEGSEKVAEDE--FDPIPVLITKNTQGLQREPNPCPVITVERFKEAVGTKGLPLYPDP 964

  Fly   951 CESVTTHEDDVRSRVVVKVRMRKKDRALVT---ATGDPSAPS------EELSPTSSDLLHKFGDR 1006
            |.:..|                |...||.:   |...||:.|      ||.:...:|:|...|.|
  Rat   965 CRAPGT----------------KTLNALESDSLAREGPSSNSSFHSSEEEGTDLEADMLDCSGSR 1013

  Fly  1007 PLLLDDELDYGS-------GESKSSTESPV-------------APILPTNPDVQE--SEEDVFAL 1049
            |||..:|.|...       ||:...::|.|             :..||.|....|  .|.||||:
  Rat  1014 PLLESEEEDESCRPLQEKLGEATLFSQSAVSVEPEERGQSGKKSRFLPVNQQASEDPGEPDVFAI 1078

  Fly  1050 APFK------LPVGVPLKRKTKPKAKPKPSEPEMWTSTPVKSAAVGDPSTNFASFPAQLTPTNNV 1108
            |||:      ..|.:..|.....|....||:.|   ...|.|.|......:...|.|....:.::
  Rat  1079 APFRSSLAPAADVDIFSKAPFVSKGSVAPSQAE---EVDVFSRAPFTKKKSVEEFLAVQGSSQDL 1140

  Fly  1109 GNSAQLDEFNEPIFNPFQENAQNTQSGETNQCDLFGLEPFPQVIRTIEQNPQHHQIHQFPSHNNN 1173
            ...|.|.:.:|.:....::.|..|.:...:....|.|:.                  ..|||
  Rat  1141 LMQANLSQPSEGLLLAGRDRAMYTPAQAQHPVTGFALQA------------------GLPSH--- 1184

  Fly  1174 NNVIKVPASVSVALPASVPVSVSVNSSAPQLVTINHSIIINKTPEPPMNYNNNNNNQTAKSSGTS 1238
                            ||.|:...:|::|:              ..|||...:.|:   ::.|.
  Rat  1185 ----------------SVQVADHFDSNSPR--------------GSPMNSGGHPND---RNRGL- 1215

  Fly  1239 SVYVNVPSFSSMSTSSCSINQPQ----SSPAAVIPVQAPL---------PVPVPAPVSVPAVPVP 1290
                                |||    |.|||..|.:...         |...|:|   .|.|:.
  Rat  1216 --------------------QPQKEAFSGPAAGKPFRPQALSKYSRHYSPEDEPSP---EAQPIA 1257

  Fly  1291 IPAVVTHLRPLLPIADNAYVQISQDRCSDFTPDDEEEPVVLRDADVVADGIGIPTPAKPKKEK 1353
            ...:|:.....| :|.:..|.....|.::....|   |..|           .|.|:|..|:|
  Rat  1258 AYKIVSQSNKQL-LAGSVSVTSLSSRTTELATAD---PFAL-----------APFPSKASKQK 1305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	183/278 (66%)
		S_TKc	47..312	CDD:214567	178/266 (67%)
Aak1	XP_017448306.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	348	1.000	Domainoid score	I1000
eggNOG	1	0.900	-	-		E1_KOG1989
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001273
OrthoInspector	1	1.000	-	-		oto97724
orthoMCL	1	0.900	-	-		OOG6_101386
Panther	1	1.100	-	-	O	PTHR22967
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X882
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.770