DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nak and Dnajc6

DIOPT Version :9

Sequence 1:	NP_477165.1	Gene:	Nak / 35154	FlyBaseID:	FBgn0015772	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	XP_006238508.1	Gene:	Dnajc6 / 313409	RGDID:	1309900	Length:	968	Species:	Rattus norvegicus

Alignment Length:	1058	Identity:	189/1058 - (17%)
Similarity:	305/1058 - (28%)	Gaps:	428/1058 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SRLENPPNSSSSSSSNEKNSFVGKVFTVGRVTVTVEDVLAEGGFAMVFLARGNGGGSSSATKYAL 78
            |....||:.:|::.|:            |..:..:|.....|.|.||   :|..|
  Rat    47 SPARQPPHRASTTDSS------------GASSPDMEPSYGGGLFDMV---KGGAG---------- 86

  Fly    79 KRMYVNNEHDL-----NVAKREIQIASNLSGHKNIIGYVDSSITPTG-----------NGVCEV- 126
             |::.|.:.:|     :.:.|.||..|:.:.......||.|.|....           |.|.::
  Rat    87 -RLFSNLKDNLKDTLKDTSSRVIQSVSSYTKGDLDFTYVTSRIIVMSFPMDSVDIGFRNQVDDIR 150

  Fly   127 -LLLMPYCKHHML------AMMNARLHVGFTE--------PEVLNIFCDIAEAVSRLHY---CQT 173
             .|...:..|:.:      :...|:.|...:|        |.:.|:|     ||.|..|   .|.
  Rat   151 SFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLF-----AVCRNMYNWLLQN 210

  Fly   174 PIIHRDLKVENILQTDAGN-------FVLCDFGSA---TAKTLNPQQHGVTVVQEEIQKYTTLSY 228
            |   :::.|.:.|...|.:       |:.|:..|.   ..:.|..::.|:.:.... ::|  |.|
  Rat   211 P---KNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSH-RRY--LGY 269

  Fly   229 RAPEMIDLYGG-------KSITTKA---------DIWALGCMLYKLCFFSLPFGESTL------- 270
                |.||...       |.:|.||         :....||..|  |  .:..||:.:
  Rat   270 ----MCDLLADKPYRPHFKPLTIKAITVSPIPFFNKQRNGCRPY--C--DVLIGETKIFSTCTDF 326

  Fly   271 ------AIQNGQFSIP-----------------------------DSSKYSKGMHQ--------L 292
                  .:|:|:..||                             ::..:....|.        :
  Rat   327 ERMKEYRVQDGKIFIPLNITVQGDVIVSMYHLRSTIGSRLQAKVTNTQIFQLQFHSGFIPLDTTV 391

  Fly   293 IKYMLEPDM------EKRPNIWQVCEVAFRLAGKDNPVQNLHKTPIPNFDLLVVPPFESE-AKRI 350
            :|: .:|::      ||.|.::||.        .|..||...|.    .||  .||:|.. .|.:
  Rat   392 LKF-TKPELDACDVPEKYPQLFQVT--------LDIEVQPQDKV----IDL--TPPWEHYCTKDV 441

  Fly   351 SAAASKAAKAQNVSVVEAGTSVAPRSRPKGSSSVHGGNPLGLG---------------------- 393
            :.:...:::.::...:..| ..||...|..    |..| ||.|
  Rat   442 NPSILFSSQQEHQDTLALG-GQAPADLPPD----HPRN-LGQGGFFASLCWQDQKSEKSRCEEDH 500

  Fly   394 --------------LPPSPSPRQNITSPQPQ--PQPVVEQFQANFPAMPPAVPPPPQAVTPAAPA 442
                          |....||..|....:|.  .:|..:|       ..||.||||:.|......
  Rat   501 AALVNQESEQSDDELLTLSSPHGNADGDKPHGAKKPGKKQ-------QEPAAPPPPEEVDLLGLE 558

  Fly   443 ASKLFESSGYPDPFNEPAAAVIPTEFLPAAEEPNKEEVPQDLNVIAGTPTKSMLTPPKPSGGGGH 507
            .|.                  :.|.|.|.|..|:..|:..||                 .||||
  Rat   559 GSD------------------VSTNFSPLAAPPSNSELLSDL-----------------FGGGG- 587

  Fly   508 RRNVSDTSAFNKTFANETSQFLAPFNNNLAAMGDGQQTLASAASNPGIYASSTANSAAVSISELM 572
                                                      |:.|.
  Rat   588 ------------------------------------------ATGPA------------------ 592

  Fly   573 KPGQTAVEKRVEAWNPFEEEQPFSQMTEDHIFEAEFDKIRQRGSQGSITAKSASTTSTLTPTEQI 637
            :.||..||      :.|....|.|..:                     |.:.|:|:::.:||.::
  Rat   593 QAGQVGVE------DVFHPSGPASAQS---------------------TPRRATTSASASPTLRV 630

  Fly   638 PSAVVAPVTAAPGAVPPPPIAAAVSPYPSQVSEDPFGSAPFSLPPGLREKASSLRKTGAKFIGVS 702
            ..........|| |.||...........|..|.|||      |.| .|..:.::..:....:.:.
  Rat   631 GEGATFDPFGAP-AKPPGQDLLGSFLNTSNASSDPF------LQP-TRSPSPTVHASSTPAVNIQ 687

  Fly   703 SGGTGG--GVATPIGLVAGGANTATS----------SNSSKWMLSPTLEVSSEEKTSLISKLKTD 755
            ....||  ..|.|.|...|..:.|||          ..|....|.|..::.:...:|..||..|.
  Rat   688 PDIAGGWDWHAKPGGFGMGSKSAATSPTGSTHGTPTHQSKPQTLDPFADLGTLGSSSFASKPTTP 752

  Fly   756 SECG------------IPGAVGGAGEGVSGY----------------------------VKLPV- 779
            :..|            .|..:||..:..:||                            ..:|.
  Rat   753 TGLGGGFPPLSSPQKASPQPMGGGWQQPAGYNWQQAQPKPQSSMPHSSPQNRPNYNVSFSAMPAG 817

  Fly   780 -EDRNKYEKLRSKDQPTSDDSDSEASEFFQQDSDEGGGGIFRQMQMVTSNLPETIHKIQQVAYHK 843
             .||.|........|..:|..|..:|:.|....|:.|              |.||.::::....|
  Rat   818 QSDRGKGSTNLEGKQKAADFEDLLSSQGFNAHKDKKG--------------PRTIAEMRKEEMAK 868

  Fly   844 VDKTAHLPIVKKLRDKTK 861
            ......|.|::.:..|.:
  Rat   869 EMDPEKLKILEWIEGKER 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	71/393 (18%)
Nak	NP_477165.1	S_TKc	47..312	CDD:214567	70/381 (18%)
Dnajc6	XP_006238508.1	PTEN_C2	281..419	CDD:287393	23/150 (15%)
Dnajc6	XP_006238508.1	DnaJ	<916..961	CDD:99751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296562at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010