DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nak and Aak1

DIOPT Version :9

Sequence 1:NP_477165.1 Gene:Nak / 35154 FlyBaseID:FBgn0015772 Length:1488 Species:Drosophila melanogaster
Sequence 2:XP_036022028.1 Gene:Aak1 / 269774 MGIID:1098687 Length:1302 Species:Mus musculus


Alignment Length:1514 Identity:445/1514 - (29%)
Similarity:639/1514 - (42%) Gaps:374/1514 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKKILSKFERNENSRLENPPNSSSSSSSNEKNSFVGKVFTVGRVTVTVEDVLAEGGFAMVFLARG 65
            |||.........:|.|.:..:....|||...:.::|:||.:||..|||::||||||||:|||.| 
Mouse     1 MKKFFDSRREQGSSGLGSGSSGGGGSSSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVR- 64

  Fly    66 NGGGSSSATKYALKRMYVNNEHDLNVAKREIQIASNLSGHKNIIGYVDSSITPTGNG-VCEVLLL 129
                :|:..|.|||||:|||||||.|.||||||..:|||||||:||:||||....:| |.|||:|
Mouse    65 ----TSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLIL 125

  Fly   130 MPYCK-HHMLAMMNARLHVGFTEPEVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTDAGNF 193
            |.:|: ..::.:||.||..||||.|||.||||..|||:|||.|:||||||||||||||..|.|::
Mouse   126 MDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHY 190

  Fly   194 VLCDFGSATAKTLNPQQHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKL 258
            |||||||||.|..|||..||..|::||:||||||||||||::||.||.||||||||||||:||||
Mouse   191 VLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKL 255

  Fly   259 CFFSLPFGESTLAIQNGQFSIPDSSKYSKGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNP 323
            |:|:||||||.:||.:|.|:|||:|:||:.||.||:||||||.:|||:|:||...:|:|..|:.|
Mouse   256 CYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECP 320

  Fly   324 VQNLHKTPIPNFDLLVVPPFESEAKRISAAASKAAKAQNVSVVEAGTSVAPRSRPKGSSSVHGGN 388
            |.|:..:|||   ..:..|.::....:.....||.....:...|  ||:|||.|||...:  ..|
Mouse   321 VPNVQNSPIP---AKLPEPVKASEAAVKKTQPKARLTDPIPTTE--TSIAPRQRPKAGQT--QPN 378

  Fly   389 PLGLGLPPSPSPRQNITSPQPQPQPVVEQFQANFPAMPPAVPPPPQAVTPAAP-AASKLFESSGY 452
            |..|.:.|:.:||:..| .||.||..   ..:|.|.:.|:|..|....||:.| .:|:..:....
Mouse   379 PGILPIQPALTPRKRAT-VQPLPQAA---GPSNQPGLLPSVSQPKAQATPSQPLQSSQPKQPQAP 439

  Fly   453 PDPFNEPAAAVIPTEFLPA--------------AEEPNKEEVPQDLNVIAGTPTKSMLTPPKPSG 503
            |.|...||.   .|:.||.              .::..:::.||.       ||    .||:|:|
Mouse   440 PTPQQTPAT---QTQGLPTQAQATPQHQQQHLLKQQQQQQQQPQQ-------PT----APPQPAG 490

  Fly   504 GGGHRRNVSDTSAFNKTFANETSQFLAPFNNNLAAMGDGQQTLASAASNPGIYASSTANSAAVSI 568
                            ||..:..|     .....|.....|.:..||..| :.|.....|...:.
Mouse   491 ----------------TFYQQQQQ-----QQQQQAQTQQFQAVHPAAQQP-VTAQFPVGSQGGAQ 533

  Fly   569 SELMKPGQTAVEKRVEAWNPFEEEQPFSQMTEDHIFEAEFDKIRQRGSQGSITAKSASTTSTLTP 633
            .:||:             |.:.::|  .|..:.....|:...::|:.:.....:::...|:....
Mouse   534 QQLMQ-------------NFYHQQQ--QQQQQQQQLMAQQAALQQKTAVVVPQSQAQPATAPQAA 583

  Fly   634 TEQIPSAVVAPVTAAP--GAVPPPPI----AAAVSPYPS----------QVSEDPFGSAPFSLPP 682
            ..|.|..:.|||...|  ...|||.|    ..:::| ||          ::..|...||.|.:| 
Mouse   584 AAQEPGQIQAPVRQQPKVQTTPPPTIQGQKVGSLTP-PSSPKTQRAGHRRILSDVTHSAVFGVP- 646

  Fly   683 GLREKASSLRKTGAKFIGVSSGGTGGGVATPIGLV-AGGANTATSSNSSKWMLSPTLEVSSEEKT 746
              ..|::.|.:..|  ...|...:.....||.|.. ....|.:.:|..|.|  :| .:..:..|.
Mouse   647 --ASKSTQLLQAAA--AEASLNKSKSATTTPSGSPRTSQQNVSNASEGSTW--NP-FDDDNFSKL 704

  Fly   747 SLISKLKTD----SECGIPGAVGGAGEG-VSGYVKLPVEDRNKYEKLRSKDQPTSDDSDSEASEF 806
            :....|..|    .|..:|..:||:.|. :.|:                  |||..|:.:..| |
Mouse   705 TAEELLNKDFAKLGEGKLPEKLGGSAESLIPGF------------------QPTQGDAFTTPS-F 750

  Fly   807 FQQDSDEGGGGIFRQMQMVTSNLP----------------------------------------- 830
            ....:::..||     |.|.|.:|                                         
Mouse   751 SAGTAEKRKGG-----QAVDSGIPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTD 810

  Fly   831 ------ETIHKIQQVAYHKVDKTAHLPIVKKLRDKTKKPTT------AAHQAAQQLNLMAAAVAA 883
                  :.:.....||...:......|:.::|..:|:..|:      ....:....:|::...|.
Mouse   811 PFGSTSDAVIDKADVAVESLIPGLEPPVAQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTAG 875

  Fly   884 QAEEAA---------KAAES----DGDSIGSASDLRAEDDDLFDENP----RQTQAKQRRPLP-- 929
            ..||.|         ||||.    .|..:...|:..|||:  ||..|    :.||..||.|.|  
Mouse   876 LLEEFAPIALSAPTHKAAEDSNLISGFGVAEGSEKVAEDE--FDPIPVLITKNTQGLQRDPSPCP 938

  Fly   930 -TEMDGISESVKTCSSSAYHAECESVTTHEDDVRSRVVVKVRMRKKDRALVT---ATGDPSAPS- 989
             ..::...||:.|.....|...|.:..|                |....|.:   |...||:.| 
Mouse   939 VITVEHFKESMGTKGLPLYPDPCRAPGT----------------KTQNTLASDSLAREGPSSNSS 987

  Fly   990 -----EELSPTSSDLLHKFGDRPLLLDDELDYGS-------GESKSSTESPV------------- 1029
                 ||.:....|:|...|.||||..:|.|...       ||:...:||.|             
Mouse   988 FHSSEEEGTDLEGDMLDCSGSRPLLESEEEDENCRPLQEKLGEAALFSESGVCTEPEERGQGGKK 1052

  Fly  1030 APILPTNPDVQE--SEEDVFALAPFKLPVGVPLKRKTKPKAKPKPSEPEMWTSTPVKSAAVGDPS 1092
            :..||.|....:  .|.||||.|||:..: ||            ..:.::::..|..|.....||
Mouse  1053 SQFLPINQRASDDLGEPDVFATAPFRSSL-VP------------ADDVDIFSKAPFVSKGSVAPS 1104

  Fly  1093 TNFASFPAQLTPTNNVGNSAQLDEFNEPIFN--PFQENAQNTQSGETNQCDLFGLEPFPQVIRTI 1155
                                |:||.:  :|:  ||.:..              .:|.|..|..:.
Mouse  1105 --------------------QMDEVD--VFSRAPFTKKR--------------SMEEFLAVQGSS 1133

  Fly  1156 EQNPQH---HQIHQFPSHNNNNNVIKVPASVSVALPASVPVSVSVNSSAPQLVTINHSIIINKTP 1217
            :..|..   .|.::.|.....:..|..||.      |..|::    ..|||....:||:.:..  
Mouse  1134 QDLPMQANLSQSNEGPLLAGRDRAIYTPAQ------AQYPMT----GFAPQAGLPSHSVQVAD-- 1186

  Fly  1218 EPPMNYNNNNNNQTAKSSGTSSVYVNVPSFSSMSTSSCSINQPQ----SSPAAVIPVQAPLPVPV 1278
                :::.|:...:..|||...|..|...            |||    |.|||..|..   |..:
Mouse  1187 ----HFDGNSPRGSPMSSGGHPVDRNRGL------------QPQKEAFSGPAAGKPFH---PQAL 1232

  Fly  1279 P------AP---VSVPAVPVPIPAVVTHLRPLLPIADNAYVQISQDRCSDFTPDDEEEPVVLRDA 1334
            .      :|   :|..|.|:....:|:.....| :|.:..|.....|.::....|   |..|   
Mouse  1233 SKYSRHYSPEDELSAEAQPIAAYKIVSQSNKQL-LAGSVSVTSLSSRTTELATAD---PFAL--- 1290

  Fly  1335 DVVADGIGIPTPAKPKKEK 1353
                    .|.|:|..|:|
Mouse  1291 --------APFPSKAGKQK 1301

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NakNP_477165.1 STKc_NAK_like 42..319 CDD:270939 183/278 (66%)
S_TKc 47..312 CDD:214567 178/266 (67%)
Aak1XP_036022028.1 STKc_NAK_like 42..316 CDD:270939 183/278 (66%)
PHA03378 <296..>429 CDD:223065 48/143 (34%)
BMP2K_C 1085..1297 CDD:405873 55/293 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 353 1.000 Domainoid score I997
eggNOG 1 0.900 - - E1_KOG1989
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 480 1.000 Inparanoid score I1447
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001273
OrthoInspector 1 1.000 - - oto94199
orthoMCL 1 0.900 - - OOG6_101386
Panther 1 1.100 - - O PTHR22967
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R972
SonicParanoid 1 1.000 - - X882
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.850

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