DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nak and gakh-1

DIOPT Version :9

Sequence 1:	NP_477165.1	Gene:	Nak / 35154	FlyBaseID:	FBgn0015772	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	NP_508971.1	Gene:	gakh-1 / 180844	WormBaseID:	WBGene00018516	Length:	570	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	165/576 - (28%)
Similarity:	251/576 - (43%)	Gaps:	77/576 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GKVFTVGRVTVTVEDVLAEGGFAMVFLARGNGGGSSSATKYALKRMYVNNEHDLNVAK---REIQ 97
            |:.|::......||.|:|:|||..||||. |..|...|.|..|       .||....|   .||.
Worm    29 GQTFSINGNNYRVEKVIAKGGFGTVFLAT-NTKGKQVAVKIML-------SHDAAATKDIDNEID 85

  Fly    98 IASNLSGHKNIIGYVDSSI--TPTGNGVCEVLLLMPYCKHHM--LAMMNARLHVGFTEPEVLNIF 158
            :...|. |:|||...|:|.  ..:...|.|..:.|.|||..:  :.:....:.:.|    |:.|.
Worm    86 MMKKLQ-HENIIQLFDASAESRSSNRSVKEYKISMEYCKFSIADVLLKYKEVSIDF----VVRII 145

  Fly   159 CDIAEAVSRLHYCQTPIIHRDLKVENILQTDAGNFVLCDFGSATAKTL------NPQQHGVTVVQ 217
            .....|:..||  ....||||:|.||:|....|...||||||||.|::      |.::   ..||
Worm   146 YFTTRALVYLH--SVGAIHRDIKAENLLINGNGKLKLCDFGSATTKSIEMAPLSNSER---LAVQ 205

  Fly   218 EEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPFGESTLAIQNGQFSIPDS 282
            ||:.||||...|:||:.|:|....|..:.|.||:||::|.:.|...||..|.|||.||::..|..
Worm   206 EEMFKYTTPITRSPEVCDVYSNWPIGKQQDNWAMGCLIYFVAFGEHPFDGSALAIINGKYKKPPP 270

  Fly   283 SKYSK--GMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNPVQNLHKTPIPN-FDLLVVPPFE 344
            .:.::  ....||...|.|:.::|....:: |...:||.:..| :...||...: .||:.|.|.:
Worm   271 VQQNQLSAFADLIAKCLTPNPDERITAAKI-EEYMKLAMQKQP-KLAAKTDFTDILDLMNVQPVQ 333

  Fly   345 SEAKRISAAASKAAKAQNVSVVEAGTSVAPRSRPKGSSSVHGGNPLGLGLPP---SPSPRQNITS 406
            :| :.|.:.|:|........:....||:.       ::.|...|.:|.|:.|   :|.|....||
Worm   334 AE-QSIESQAAKGFFTMQDKLFSNLTSLK-------NTVVQQTNKMGWGMEPTNTTPRPGHPSTS 390

  Fly   407 PQ--PQPQPVVEQFQANFPAMPPAVPPPPQAVTPAA------PAASKLFESSGYPDPFNEPAAAV 463
            |:  |:.....:|.:.|.|..||....|..|  |.|      |..|...:|:.....|::...||
Worm   391 PKLVPKTHRSNQQQEKNAPPRPPTTASPRAA--PVATFKVSWPTDSSQNDSANDWGDFSQAPPAV 453

  Fly   464 IPTE---FLPAAEEPN---KEEVPQDLNVIAGTPTKSMLTPPKPSGGGGHRRNVSDTSAFNKTFA 522
            ..::   |.|.:|..:   ..:..:||..:...|..:...|...|.......:..|....:.|.:
Worm   454 NVSKKDVFDPFSESASHNLSAKHSEDLLSLQNWPGTAEHKPEVRSQSSRDLFDFDDLMLRHTTPS 518

  Fly   523 NETSQ-FLAPF----NNNLAAMGDGQQTLASAASNPGIYASSTANSAAVSISELMK 573
            .|:|| .|.|.    |.||..:.         .|..||.:||::.|....:|::||
Worm   519 AESSQAVLQPIRQVENKNLTKVD---------VSKNGIGSSSSSASLDDMVSDMMK 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	96/291 (33%)
Nak	NP_477165.1	S_TKc	47..312	CDD:214567	94/279 (34%)
gakh-1	NP_508971.1	PKc_like	38..304	CDD:389743	95/284 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1989
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D296562at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22967
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920