DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nak and aak1b

DIOPT Version :9

Sequence 1:	NP_477165.1	Gene:	Nak / 35154	FlyBaseID:	FBgn0015772	Length:	1488	Species:	Drosophila melanogaster
Sequence 2:	XP_009303928.1	Gene:	aak1b / 100534954	ZFINID:	ZDB-GENE-091118-25	Length:	1055	Species:	Danio rerio

Alignment Length:	1269	Identity:	400/1269 - (31%)
Similarity:	539/1269 - (42%)	Gaps:	369/1269 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSKFERNENSRLENPPNS-----SSSSSSNEKNSFVGKVFTVGRVTVTVEDVLAEGGFAMVFLAR 64
            :.||..:....:.:.|.|     .|.|.|....:|:|:.|||||..||||:.|||||||:|||.|
Zfish     1 MKKFFDSRRELVGSGPGSGGGAGGSGSGSGAGGNFIGRNFTVGRHQVTVEETLAEGGFAIVFLVR 65

  Fly    65 GNGGGSSSATKYALKRMYVNNEHDLNVAKREIQIASNLSGHKNIIGYVDSSITPTGNG-VCEVLL 128
            .|.|     .:.|||||||||||||.|.||||||..:|:|||||:|::|||||..|.| |.||.:
Zfish    66 TNQG-----VRCALKRMYVNNEHDLQVCKREIQIMRDLNGHKNIVGFLDSSITAVGGGDVWEVFI 125

  Fly   129 LMPYCK-HHMLAMMNARLHVGFTEPEVLNIFCDIAEAVSRLHYCQTPIIHRDLKVENILQTDAGN 192
            ||.:|: ..::.:||.||..||:|.|.|.||||..|||:|||..:||||||||||||||..|.|:
Zfish   126 LMDFCRGGQVVNLMNQRLQTGFSEQEALQIFCDTCEAVARLHQYKTPIIHRDLKVENILLHDRGH 190

  Fly   193 FVLCDFGSATAKTLNPQQHGVTVVQEEIQKYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYK 257
            :|||||||||.|..|||..|||.|::||:||||||||||||::||.||.|||||||||:||:|||
Zfish   191 YVLCDFGSATMKFQNPQSEGVTAVEDEIKKYTTLSYRAPEMVNLYNGKIITTKADIWAMGCLLYK 255

  Fly   258 LCFFSLPFGESTLAIQNGQFSIPDSSKYSKGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDN 322
            ||||:||||||.:||.:|.|:|||:|:||:.||:||:||||||.:|||:|:||...||:||.:|.
Zfish   256 LCFFTLPFGESQVAICDGNFTIPDNSRYSQDMHRLIRYMLEPDPDKRPDIYQVSFFAFKLARRDC 320

  Fly   323 PVQNLHKTPIPNFDLLVVPPFESEAKRISAAASKAAKAQNVS-----VVEAGTSVAPRSRPKGSS 382
            ||||:..:|||    ..:|    |..|.|.||:|.::.|..:     :....||:.||.|||.:.
Zfish   321 PVQNVKNSPIP----AKLP----EPIRASEAAAKKSQTQTKARLTDPIPTTETSITPRQRPKAAQ 377

  Fly   383 SVHGGNPLGLGLPPSP---SPRQNI-----------------------------TSPQP----QP 411
            |  ....||..||..|   :||:..                             .||.|    ||
Zfish   378 S--QSQALGGILPIQPAALTPRKRANLPAGAAQPIAVSVNLAQPAAALQSQKAQASPAPQQKTQP 440

  Fly   412 QPV-VEQFQANFPAMPP------AVPPPPQAVTPAAPAASKLFESSGY--------PDPFNEPAA 461
            .|| |.......||..|      |.|||.....|.|||.|...:.:..        |....:||.
Zfish   441 IPVTVTATAGGIPAASPTPQKAVATPPPSSPAPPTAPARSARRKQASVAQQQSVVAPPTATQPAV 505

  Fly   462 AVIPTEFLPAAEEPNKEE-------VPQDLNVIAGTPTKSMLTP--PKPSGGGGHRRNVSDTSAF 517
            |..|.:..|.|..|..::       .|:|.......|..|...|  |:.:...||||..||.:
Zfish   506 AQPPAQAEPTAAPPTVQQPAPQSQISPEDAEERPAAPGLSQTPPSSPRTAQKAGHRRIQSDVT-- 568

  Fly   518 NKTFANETSQFLAPFNNNLAAMGDGQQTLASAASNPGIYASST-ANSAAVSISELMKPGQTAVEK 581
                  .::.|..|.:.:...:   |...|.|:.|....||:| :||...|...:.:|.|.....
Zfish   569 ------HSAMFGVPVSQSTQQL---QAATAEASLNKSKSASATPSNSPQSSQQSVYQPAQQQASV 624

  Fly   582 RV----------------EAWNPFEEEQPFSQMTEDHIFEAEFDKIRQRGSQGSITAKSASTTST 630
            .|                ..||||:::. ||::|.:.:...:|.|:.....:..|.     |:.:
Zfish   625 SVPQAPASAANLTSPPTQPTWNPFDDDN-FSKLTAEDLLNKDFTKLADEPVEPLIV-----TSDS 683

  Fly   631 LTPTEQIPSAVVAPVTAA----------PG----AVPPPPIAAAVSP-----YPSQVS-EDPFGS 675
            |.|  .:.:|..||.::|          ||    |||...|....||     .|..:| .|||||
Zfish   684 LIP--GLEAAESAPPSSAERPADILGLEPGAGLLAVPEKLIEGLKSPDTSLMLPDLLSMADPFGS 746

  Fly   676 A------------PFSLPPGLREKASSLRKTGAKFIGVSSGGTGGGVATPIGLVAGGANTATSSN 728
            :            ..||.|||....:.|:...|
Zfish   747 SIEETRDVNTDVCLDSLIPGLEPPQAQLQPVEA-------------------------------- 779

  Fly   729 SSKWMLSPTLEVSSEEKTSLISKLKTDSECGIPGAVGGAGEGVSGYVKLPVEDRNKYEKLRSKDQ 793
                           |..||:   .||...|....:||
Zfish   780 ---------------ESASLV---LTDPLIGDDSLLGG--------------------------- 799

  Fly   794 PTSDDSDSEASEFFQQDSDEGGGGIFRQMQMVTSNLPETIHKIQQVAYHKVDKTAHLPIVKKLRD 858
            |.|..|.|...:|    :...||        .:.|:|
Zfish   800 PLSSSSASCLDDF----AVLSGG--------PSQNIP---------------------------- 824

  Fly   859 KTKKPTTAAHQAAQQLNLMAAAVAAQAEEAAKAAESDGDSIGSASDLRAEDDDLFDENPRQTQAK 923
                        |.:..|::....:.||.|                    ::|.||..|......
Zfish   825 ------------AAEPCLISGFEPSSAETA--------------------NEDEFDPIPVLVSKN 857

  Fly   924 QRRPLPTEMDGISESVKTCSSSAYHAECESVTTHEDDVRSRVVVKVRMRKKDRALVTATGDPSAP 988
            .:..|| .::| :||.....||...||.|    .|::|       :.|....:.|:..:...:..
Zfish   858 SQDDLP-NVNG-NESASCIQSSDVPAEEE----EEEEV-------LHMCSGSKLLLLDSKLLNTT 909

  Fly   989 SEELSPTSS-DLLHKFGDRPLLLDDELDYGSGESKSS--TESPVAPILPTNPDVQESEEDVFALA 1050
            |.:|||:|| |:   |...|.       .|.|.....  |.:|...|.|::|     :.|||..|
Zfish   910 SLKLSPSSSPDV---FSSAPF-------PGCGPDSRDIFTSAPFPQIQPSHP-----QPDVFLQA 959

  Fly  1051 PFKLPVGVPLKRKTKPKAKPKPSEPEMWTSTPVKS-----------------------AAVGDPS 1092
            ||       .||.....|:....:..:....||.|                       ::||..:
Zfish   960 PF-------YKRSESHVAQISNGDDPVLPHPPVHSQIRFPYCAEAPMPQQPIAAHRVVSSVGQQA 1017

  Fly  1093 TNFASFPAQLTPTNNVGNSAQLDEFNEPIFNPFQ 1126
            . .:|.|.....:..||..|.:|.|   :..|||
Zfish  1018 A-ISSVPVGPLHSWTVGVQAVMDPF---LAAPFQ 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	182/278 (65%)
Nak	NP_477165.1	S_TKc	47..312	CDD:214567	176/266 (66%)
aak1b	XP_009303928.1	STKc_NAK_like	43..316	CDD:270939	181/277 (65%)
		S_TKc	48..308	CDD:214567	174/264 (66%)
		BMP2K_C	810..1049	CDD:291930	68/349 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	359	1.000	Domainoid score	I917
eggNOG	1	0.900	-	-		E1_KOG1989
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001273
OrthoInspector	1	1.000	-	-		otm24445
orthoMCL	1	0.900	-	-		OOG6_101386
Panther	1	1.100	-	-	O	PTHR22967
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X882
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.770