DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10623 and Mtr

DIOPT Version :9

Sequence 1:	NP_001286073.1	Gene:	CG10623 / 35153	FlyBaseID:	FBgn0032727	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_110491.2	Gene:	Mtr / 81522	RGDID:	621283	Length:	1253	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	84/347 - (24%)
Similarity:	143/347 - (41%)	Gaps:	57/347 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KPILVKCGGFSS--QLAKNVTEKVDGD-------PLWGSR--FDATNPEAVIQTHLDFLRNGADI 65
            |.|:|..||..:  |..|...|...|.       ||.|:.  ...|.|:.:.|.|.::|..||||
  Rat    15 KRIMVLDGGMGTMIQRYKLSEENFQGQEFKDHSRPLKGNNDILSITQPDVIYQIHKEYLLAGADI 79

  Fly    66 ILTNTYQSSVEGFVKYLGVTRERGVE-----LIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGS 125
            |.|||:.|:......|       |:|     :.:.|..:|::|.|:...:.|.:.     .:.||
  Rat    80 IETNTFSSTSIAQADY-------GLEHLAYRMNKCSADVARKAAEEITLQTGVKR-----FVAGS 132

  Fly   126 IGPYGAYLHDGSEYTGNYADKMSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAE----AVT 186
            :||....|.............::.:||...::.:.:..|..|||.|.:||:.....|:    |:.
  Rat   133 LGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQ 197

  Fly   187 ELVLDNFPDAK-FWVSLQCMDEKHMA----SGENFAEAALSLWRLVQSRKAENRLLGIGLNC-VN 245
            :|..:|:...: .::|...:|:....    :||.|..:.           :.:..|.||||| :.
  Rat   198 KLFEENYASPRPIFISGTIVDKSGRTLSGQTGEAFVTSV-----------SHSDPLCIGLNCALG 251

  Fly   246 PLFVTPLLSSLTKVAGSDRIPLVVYSNRGEIYDVEQGDWTGTGEEVVKFVPEWIQLG-VRIVGGC 309
            ...:.|.:.::.|...:   .::.|.|.|  .....||:..|...:...:.::...| |.:||||
  Rat   252 AAEMRPFIETIGKCTTA---YVLCYPNAG--LPNTFGDYDETPAMMAMHLKDFAVDGLVNVVGGC 311

  Fly   310 CRVYPTDVLAIRKYVDGLNIKP 331
            |...|..:..|.:.|.  |.||
  Rat   312 CGSTPDHIREIAEAVK--NCKP 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10623	NP_001286073.1	S-methyl_trans	9..322	CDD:304616	80/336 (24%)
Mtr	NP_110491.2	metH	1..1249	CDD:236539	84/347 (24%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q99707	370..372
		Methylcob(III)alamin binding. /evidence=ECO:0000250\|UniProtKB:P13009	770..774
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250	1215..1216
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11284
eggNOG	1	0.900	-	-		E1_COG0646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D518534at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44974
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820