DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10623 and MTR

DIOPT Version :9

Sequence 1:	NP_001286073.1	Gene:	CG10623 / 35153	FlyBaseID:	FBgn0032727	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	XP_011542496.1	Gene:	MTR / 4548	HGNCID:	7468	Length:	1321	Species:	Homo sapiens

Alignment Length:	342	Identity:	79/342 - (23%)
Similarity:	133/342 - (38%)	Gaps:	57/342 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WNWDTKPI-LVKCGGFSSQLAKNVTEKVDGDPLWGSRFDATNPEAVIQTHLDFLRNGADIILTNT 70
            |.|...|: :|.||......|.:..         |......:|.:....:.::|..|||||.|||
Human    98 WRWLAWPLAVVTCGEHVFSAAPSAQ---------GGDSTTCHPRSKTCRNPEYLLAGADIIETNT 153

  Fly    71 YQSSVEGFVKYLGVTRERGVE-----LIQKSVQLAKQAKEQYLSEIGSEAESALPLIMGSIGPYG 130
            :.|:......|       |:|     :...|..:|::|.|:...:.|.:.     .:.|::||..
Human   154 FSSTSIAQADY-------GLEHLAYRMNMCSAGVARKAAEEVTLQTGIKR-----FVAGALGPTN 206

  Fly   131 AYLHDGSEYTGNYADKMSKEELRAWHKTRIEICLAAGVDGLALETLPCLMEAEAVTELVLDNFPD 195
            ..|.............::.:||...::.:.:..|..|||.|.:||:.....|:|.. ..|.|..:
Human   207 KTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAAL-FALQNLFE 270

  Fly   196 AKF-----WVSLQCMDEKHMA----SGENFAEAALSLWRLVQSRKAENRLLGIGLNC-VNPLFVT 250
            .|:     ::|...:|:....    :||.|..:.           :....|.||||| :....:.
Human   271 EKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISV-----------SHGEPLCIGLNCALGAAEMR 324

  Fly   251 PLLSSLTKVAGSDRIPLVVYSNRGEIYDVEQGDWTGTGEEVVKFVPEWIQLG-VRIVGGCCRVYP 314
            |.:..:.|...:   .::.|.|.|  .....||:..|...:.|.:.::...| |.||||||...|
Human   325 PFIEIIGKCTTA---YVLCYPNAG--LPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTP 384

  Fly   315 TDVLAIRKYVDGLNIKP 331
            ..:..|.:.|.  |.||
Human   385 DHIREIAEAVK--NCKP 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10623	NP_001286073.1	S-methyl_trans	9..322	CDD:304616	74/329 (22%)
MTR	XP_011542496.1	metH	140..1317	CDD:236539	70/291 (24%)
		MetH1	140..396	CDD:223719	67/286 (23%)
		MeTr	427..683	CDD:238381
		methionine_synthase_B12_BD	727..953	CDD:239020
		Met_synt_B12	1021..1302	CDD:281030
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11469
eggNOG	1	0.900	-	-		E1_COG0646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D518534at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8560
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2187
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850