DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10621 and MHT1

DIOPT Version :9

Sequence 1:	NP_001286071.1	Gene:	CG10621 / 35152	FlyBaseID:	FBgn0032726	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_013038.1	Gene:	MHT1 / 850664	SGDID:	S000003985	Length:	324	Species:	Saccharomyces cerevisiae

Alignment Length:	343	Identity:	97/343 - (28%)
Similarity:	165/343 - (48%)	Gaps:	64/343 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVLVKDGGFGTQMTVHVGDSVDGDPLWSAR-FNATN---PAA-----IISTHLDFLQNGADIILT 60
            :||:.|||.||::. :.|.::: .|:|||. |.:.:   |::     :...:.||:..||:|::|
Yeast    16 KVLILDGGQGTELE-NRGININ-SPVWSAAPFTSESFWEPSSQERKVVEEMYRDFMIAGANILMT 78

  Fly    61 NTYQSSVDGYMEYLELDEEQSIELIKNTVRLAHIAKERYLTE--CYQAQLSVQEGYPLIIASIGP 123
            .|||::      :..:.|..||:.:        .|.:|:|.:  .:..:...:|.|  :|.||||
Yeast    79 ITYQAN------FQSISENTSIKTL--------AAYKRFLDKIVSFTREFIGEERY--LIGSIGP 127

  Fly   124 FGAHLHDGSEYTGSYADFVPAKEITDWH---RVRIEACLE-AGVDALAIETIPCQMEAEALVEML 184
            :.||:  ..||||.|.   |..|..|::   :.::|...: ..:|.:..||||...|.:|::..
Yeast   128 WAAHV--SCEYTGDYG---PHPENIDYYGFFKPQLENFNQNRDIDLIGFETIPNFHELKAILSW- 186

  Fly   185 CDDYPDVKFWVAFQCKDENTLAHGETFADAANAIWDLLAERNAQDKCLAIGVNCVHPKFVTPLFK 249
            .:|.....|::.....|.:.|..|.|..:.:..|..|..:.|  ...|.:|||||.......:.|
Yeast   187 DEDIISKPFYIGLSVDDNSLLRDGTTLEEISVHIKGLGNKIN--KNLLLMGVNCVSFNQSALILK 249

  Fly   250 SLNGDREVGEQIPLVVYPNSGEVY-----------DVVNGWQGREHCVPLANYVPEWAQLGAKVI 303
            .|:   |....:||:|||||||:|           :.::.|:         ..|.::...||::|
Yeast   250 MLH---EHLPGMPLLVYPNSGEIYNPKEKTWHRPTNKLDDWE---------TTVKKFVDNGARII 302

  Fly   304 GGCCRTYARDIRHIGEAI 321
            ||||||..:||..|..|:
Yeast   303 GGCCRTSPKDIAEIASAV 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10621	NP_001286071.1	mmuM	5..323	CDD:181899	97/343 (28%)
MHT1	NP_013038.1	MHT1	6..324	CDD:224951	97/343 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345612
Domainoid	1	1.000	93	1.000	Domainoid score	I1699
eggNOG	1	0.900	-	-		E1_COG0646
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I1490
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62632
OrthoFinder	1	1.000	-	-		FOG0002464
OrthoInspector	1	1.000	-	-		mtm9206
orthoMCL	1	0.900	-	-		OOG6_102920
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2187
SonicParanoid	1	1.000	-	-		X3176
TreeFam	1	0.960	-	-
	13	12.690