DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10621 and Mtr

DIOPT Version :9

Sequence 1:NP_001286071.1 Gene:CG10621 / 35152 FlyBaseID:FBgn0032726 Length:331 Species:Drosophila melanogaster
Sequence 2:NP_001074597.1 Gene:Mtr / 238505 MGIID:894292 Length:1253 Species:Mus musculus


Alignment Length:363 Identity:84/363 - (23%)
Similarity:146/363 - (40%) Gaps:96/363 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 RVLVKDGGFGTQMTVHVGDSVDGDPLWSARF--------------NATNPAAIISTHLDFLQNGA 55
            |::|.|||.||.:..:   .:..:......|              :.|.|..|...|.::|..||
Mouse    16 RIMVLDGGMGTMIQRY---KLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGA 77

  Fly    56 DIILTNTYQSS----VDGYMEYLELDEEQSIELIKNTVRLAHIAKERYLTECYQAQLSVQEGYPL 116
            |||.|||:.|:    .|..:|:|      :..:.|.:..:|..|.|         ::::|.|...
Mouse    78 DIIETNTFSSTSIAQADYGLEHL------AYRMNKCSADVARKAAE---------EITLQTGVKR 127

  Fly   117 IIA-SIGPFGAHLH-----DGSEYTGSYADFVPAKEITDWHRVRIEACLEAGVDALAIETIPCQM 175
            .:| ::||....|.     :..:|.....|     |:.|.::.:.:..|:..||.|.||||....
Mouse   128 FVAGALGPTNKTLSVSPSVERPDYRNITFD-----ELVDAYQEQAKGLLDGRVDILLIETIFDTA 187

  Fly   176 EAE----ALVEMLCDDY-PDVKFWVAFQCKDEN--TLA--HGETFADAANAIWDLLAERNAQDKC 231
            .|:    |:..:..::| |....:::....|::  ||:  .||.|..:.           :....
Mouse   188 NAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQTGEAFVTSV-----------SHSDP 241

  Fly   232 LAIGVNC------VHPKFVTPLFKSLNGDREVGEQIPLVVYPNSG-----EVYDVVNGWQGREHC 285
            |.||:||      :.| |:..:.|....        .::.|||:|     ..||        |..
Mouse   242 LCIGLNCSLGAAEMRP-FIETIGKCTTA--------YVLCYPNAGLPNTFGDYD--------ETP 289

  Fly   286 VPLANYVPEWAQLG-AKVIGGCCRTYARDIRHIGEAIR 322
            ..:|.::.::|..| ..::||||.:....||.|.||::
Mouse   290 STMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVK 327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10621NP_001286071.1 mmuM 5..323 CDD:181899 84/363 (23%)
MtrNP_001074597.1 metH 1..1249 CDD:236539 84/363 (23%)
MetH1 8..328 CDD:223719 84/363 (23%)
MeTr 359..615 CDD:238381
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q99707 370..372
methionine_synthase_B12_BD 659..885 CDD:239020
Methylcob(III)alamin binding. /evidence=ECO:0000250|UniProtKB:P13009 770..774
Met_synt_B12 954..1234 CDD:281030
S-adenosyl-L-methionine binding. /evidence=ECO:0000250 1215..1216
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11743
eggNOG 1 0.900 - - E1_COG0646
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2187
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.840

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