DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10621 and metr-1

DIOPT Version :9

Sequence 1:	NP_001286071.1	Gene:	CG10621 / 35152	FlyBaseID:	FBgn0032726	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_496353.1	Gene:	metr-1 / 174681	WormBaseID:	WBGene00010988	Length:	1249	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	80/365 - (21%)
Similarity:	142/365 - (38%)	Gaps:	100/365 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVLVKDGGFGTQMTVHVGDSVD--GD-------PLWSAR--FNATNPAAIISTHLDFLQNGADII 58
            |:::.||..||.:.....:..|  |:       ||....  .:.|.|..|...|..:|:.|||.:
Worm    17 RIMIIDGAMGTMIQREYMEEEDFRGEILKDHDKPLKGNNDLLSITRPDIIYKIHKLYLEAGADFV 81

  Fly    59 LTNTYQSSVDGYMEYLELDEEQSIELIKNTVRLAHIAKERYLTECYQAQLSVQEGYP-------- 115
            .|||:..:.....:|                |..|:..|..    ||:.|..:....
Worm    82 ETNTFSGTTIAQADY----------------RCEHLVHEIN----YQSALVARRACDDVGAATGR 126

  Fly   116 --LIIASIGPFGAHLHDGSEYTGSYADFVPAKEITDWHRVRIE-----------ACLEAGVDALA 167
              .:..:|||           |.......|:.|..|:..|..:           :.::.|||.|.
Worm   127 RRYVCGAIGP-----------TNRTLSISPSVEKPDFRNVTFQELVKAYGDQARSLIQGGVDVLL 180

  Fly   168 IETIPCQMEAEA---LVEMLCDD--YPDVKFWVAFQCKDEN--TLA--HGETFADAANAIWDLLA 223
            :||:.....|:|   .:..|.:|  .|::..:::....|.:  ||:  .||.|         |::
Worm   181 VETVFDSANAKAALFAIRTLFEDEGVPEMPVFLSGTIVDMSGRTLSGQTGEAF---------LVS 236

  Fly   224 ERNAQDKCLAIGVNCV-----HPKFVTPLFKSLNGDREVGEQIPLVVYPNSGEVYDVVNGWQGRE 283
            .:  |.|.:|:|:||.     ..:||..:.|..:..        ::.|||:| :.:.:.|:.  |
Worm   237 TK--QGKPMAVGLNCALGAKDMRQFVDNMSKWSDSF--------IICYPNAG-LPNALGGYD--E 288

  Fly   284 HCVPLANYVPEWAQLG-AKVIGGCCRTYARDIRHIGEAIR 322
            ....:|:.:.|:|:.| ..:|||||.|....|..:.:|::
Worm   289 TPEEMADVLREFARDGLVNIIGGCCGTTPDHINAMYKAVQ 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10621	NP_001286071.1	mmuM	5..323	CDD:181899	80/365 (22%)
metr-1	NP_496353.1	metH	1..1245	CDD:236539	80/365 (22%)
		MetH1	3..329	CDD:223719	80/365 (22%)
		MeTr	360..615	CDD:238381
		methionine_synthase_B12_BD	661..886	CDD:239020
		Met_synt_B12	954..1230	CDD:281030
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0646
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D518534at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2187
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850