DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10428 and CARM1

DIOPT Version :9

Sequence 1:	NP_609918.1	Gene:	CG10428 / 35150	FlyBaseID:	FBgn0032724	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_954592.1	Gene:	CARM1 / 10498	HGNCID:	23393	Length:	608	Species:	Homo sapiens

Alignment Length:	312	Identity:	62/312 - (19%)
Similarity:	97/312 - (31%)	Gaps:	85/312 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 EVVRFEQHMNEPVRMHNIYKQAREQANQTENGGKVKRRERVQIKCTTPKEELLIEHRFAE----- 222
            |.....||....|:.:|:..:......:.|   :|...|:|.|..:.|...:|...|..|
Human   214 EASTMAQHAEVLVKSNNLTDRIVVIPGKVE---EVSLPEQVDIIISEPMGYMLFNERMLESYLHA 275

  Fly   223 -------GISF-TIADIILYPLLRIVFQHCGQMLPHFPLTSTWFSEIDSFGDKCARVLRDLYVPQ 279
                   |..| ||.|:.|.|     |......:..|...:.|:.  .||.......||...|.:
Human   276 KKYLKPSGNMFPTIGDVHLAP-----FTDEQLYMEQFTKANFWYQ--PSFHGVDLSALRGAAVDE 333

  Fly   280 AIKTPPGELGIPDCEATSLYKADPKRYKPRNRIYTSQLELEAALSKLSSLQLQFNSDSEHT---- 340
            ..:.|     :.|.....:..|...:|...        .|||....|..:::.|.....|:
Human   334 YFRQP-----VVDTFDIRILMAKSVKYTVN--------FLEAKEGDLHRIEIPFKFHMLHSGLVH 385

  Fly   341 ----------YGQQLIDWEQIEPTHAKSSALPKERLERKRQQLENLANAVVSLAQPGDRIVDFCS 395
                      .|..:..|....||.      |.....:.|...::     ...|:.||.:    |
Human   386 GLAFWFDVAFIGSIMTVWLSTAPTE------PLTHWYQVRCLFQS-----PLFAKAGDTL----S 435

  Fly   396 GTGHLAILLALKLPNCTIIVMENKAFSL-LQAQ------KRSNELGLTNCVF 440
            ||             |.:|..:.:::.: :.||      |.||.|.|.|..|
Human   436 GT-------------CLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFF 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10428	NP_609918.1	GST_C_family	<212..258	CDD:198286	12/58 (21%)
CG10428	NP_609918.1	AdoMet_MTases	368..486	CDD:302624	18/80 (23%)
CARM1	NP_954592.1	CARM1	34..138	CDD:288395
		PRMT5	<172..435	CDD:282971	48/258 (19%)
		Methyltransf_18	184..283	CDD:289607	14/71 (20%)
		Transactivation domain. /evidence=ECO:0000250	499..608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900