DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp3 and Y6B3B.4

DIOPT Version :9

Sequence 1:	NP_609917.2	Gene:	ssp3 / 35149	FlyBaseID:	FBgn0032723	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	NP_001364617.1	Gene:	Y6B3B.4 / 189368	WormBaseID:	WBGene00012389	Length:	1311	Species:	Caenorhabditis elegans

Alignment Length:	1395	Identity:	270/1395 - (19%)
Similarity:	493/1395 - (35%)	Gaps:	414/1395 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 KTNPGSILSTATRTKMSSRLSSREDITSSTSTLKA----------SNEQLSNSRNT-LKAENQHS 611
            |....|::|.:::.|.:.:..:|: .|.....||.          |.:.::..:.. |..::..:
Worm     6 KEKAESVVSRSSKKKKNRKKRARQ-WTGYVENLKTTCDLMYEMCRSEQSVTGCKEAMLYLQSASN 69

  Fly   612 EPKQIQPPTDADDGWLTVKNR----RRTSMHWANRFNQPTGYASLPTLALLNEQQKEQEHKEKQK 672
            :.|.:....:.:..|...:||    :|.|:.|..|.:..:...:||..:::.|..|.......:.
Worm    70 DFKSLIETINVEKQWDQDENRQEQIKRPSVAWEVRKSMSSPNPALPISSIIAEAVKNASPPTNKA 134

  Fly   673 GEDDGKVIVKTISAKTKAPIEVAKAKAKTSIVITRPE-----IKNAKAKVNS----------FPV 722
            .|.     ..|.|:.......:..|.|..::.:::|:     :.|.:.|..|          |.|
Worm   135 AEP-----FPTPSSSNLTYARITAAAAVAAVAVSQPDDGWKLVTNRRRKSTSSTTASEFDREFSV 194

  Fly   723 QKSNTNQVKKPE----------------KQEKSDT-TAPAAIASSSNTRNSSHSICVGRNSIIKR 770
            :|.     |:||                |:..:.| |.|.:......||.|...:...|..:.::
Worm   195 EKE-----KEPENPCPLNVYERLSSTSYKRTSTRTLTCPKSAMDLPQTRASMAKMAYSRQLLWEK 254

  Fly   771 QKSDLTGLKMTSLHKEYMRSEKN------------ALRK----LQQKEQGNQQHNSSSSSAETVV 819
            .:..|    :..|.:...|.:|:            |:||    ..||:.|:::....:.:..:.:
Worm   255 NQQVL----VEKLRQRQKREKKSNVQCGFTFADPLAVRKSVEEFNQKKIGSRRQGKETPTTSSNI 315

  Fly   820 E--SCNEDHSKIDIKIQTNCEFSKTIGELYESIAHCKLPSGSLKTNASTLSA---CDENEEQNTD 879
            |  |.||:.:.:......|.          |.:.....||.|:.....|.:.   ....||...|
Worm   316 ELHSINEEPTTVHPASSENS----------EDVPADPTPSSSISQPPPTTTLFGYVQVPEELEKD 370

  Fly   880 D--NEEERNERILGEVQESLERQIRELEQTEIDVDTETDETDCEVQLEEQDDGVDGLEMGSGDDS 942
            |  .|....|..|...:.||..:|::.|..|||.:.|.     :|::|     .|.||...
Worm   371 DEWREMTEEEESLALEENSLNLEIKQAEAMEIDAELER-----QVEME-----ADKLEREH---- 421

  Fly   943 AVFVTMSDDENASLELRYQALLSDM-------------SWNERAEALATLQAYVARH-----PGR 989
                 ..:.:|...|.:.|....:|             :|:|..|..:..|..:..|     ||.
Worm   422 -----RKNQKNLKKEEKKQEKQQEMENFFKVFEEIRSLAWSELMEQESVAQYQLHHHQNVHEPGT 481

  Fly   990 AQELHQKLSSPSRRRSLQET---LKKYQAKQARAQQKRNLLQQEKAAKLQQLFSRVEDVKAAKNQ 1051
            ..|.|:|:.||||||..::.   .|:::.||..|::.|..||:.||:||::|.||||:|:..:..
Worm   482 HVERHEKMLSPSRRRGHKDDDDFGKRHEMKQKHAEELRQQLQEAKASKLKELTSRVEEVRMKQEA 546

  Fly  1052 IIEDKRQKMQGRLQRAAENREQYLKQIIEKAHDEEKKLKEINFIKNIEAQNKRLDLLESSKETEG 1116
            :.|.|||.::.|:|||::||::.:.::|.:|.|:::::.|:.||..::..|||.:||......|.
Worm   547 LKERKRQLLEARMQRASDNRDKNIMEVIRRAKDDDQRVMEVKFIATLQEDNKRYELLAKDASVEE 611

  Fly  1117 RLQDLEQERQKRVEEKLAKE-----AAVERRRQALEKERLLKLEKMNETRLEKEQRIGKMQE--- 1173
            :.:.|..||.::.|||.||:     ||..||.||.| :|..::.|::|   :||.|.||.:.
Worm   612 KQKQLADERARKHEEKAAKKREQEAAATARRAQAAE-QRQCRIRKLSE---QKEIRHGKKENPAP 672

  Fly  1174 -------------------------------------------------------------QKEK 1177
                                                                         .||.
Worm   673 SAPEDMLQYLNSLLLTEPVNSEPLPYLWPSTEHLAPRQCSLCSAVSTVIHSDLDAISHVLCSKEH 737

  Fly  1178 QRQA----------------------------LAREKARDREERLL------------------- 1195
            |.||                            :|.|:...|||.::
Worm   738 QIQAKTLTSGSMIEELKRHFFGIFKEVTVGDGVAIEEKNQREEAMMKAKAFLGKIQLSDSLPAPP 802

  Fly  1196 -------------ALQVQQQQTTEELQRKILQKQME---------------SARRHEENIEH--- 1229
                         .|..::.||.:...:::|:|.:.               ||.....|:|.
Worm   803 SSPRNRTKCVRDFILAHEKLQTNDPKTQEMLEKSLSELVQAVETDWKASTASADASSLNLEQFCA 867

  Fly  1230 ----------------------------------------------------IRQRALELTIPTR 1242
                                                                :.::.||| :...
Worm   868 IQGPQKLLEMLLEWTKGGATLRLCIRVCHVFCVFLKDPRVAYAVIFKPELLKLTEKILEL-VAVV 931

  Fly  1243 QADEGRGDQDVSEDILNG--NATSTTNEDCDLSSSLSEVGGNNAHTRSYKKKMKKLKQRMNQCAA 1305
            .|:.|   |:.||:..|.  |..:||.:..: |...::....||...| |......:...|....
Worm   932 GAENG---QNSSENAQNSSENGQNTTKKGQN-SPKNAQNSSENAQNSS-KNGQNSSENDQNSSEN 991

  Fly  1306 EYLESLEALPAHARRDSTVPKLLNLVVKGGGAQGLDRNLGNLLRVIPKAQTLDFLAFLCMDGLGI 1370
            ....|..|..:.....::...:.|....|..:....:|..|..::...:..|:.|| .|:.....
Worm   992 SQNSSKNAQNSAENAQNSTRNVQNPSENGQNSPENAQNSPNSQKLPQLSALLNVLA-TCLKSAAQ 1055

  Fly  1371 LAN---HVISKGMDENSEISRKSVYLAAQLYRNACSVCPQIARHALLGNSITVLFDAINKSFQLP 1432
            .||   ....|...|..|: :|..:||||    |.|......|::|..|.|.::.
Worm  1056 RANLPGKPTKKHQKEQKEL-QKLDFLAAQ----AISAVSSFLRNSLSPNDIKLVL---------- 1105

  Fly  1433 EEKSPQHPVELSTELMLACTEALSSSY-------VKKNTH--PKVPERLPDMINYAV--ITGLIE 1486
              :..:.||.|:|.|:.....:.|:..       |.::|:  .:..|...::::..:  .:|:::
Worm  1106 --RGARGPVLLATRLLGLAEHSGSAELLGIMGGAVLEHTYELKRAGEPCKELVSIVIPACSGILK 1168

  Fly  1487 ILSRRIQKVRESIESNKSVMLSLLTTLGFLSRFIDVCQPGPADPTRLLSAAKSTELFGTVSMLYG 1551
            ..|...||:        .:|..:|......|....:...|..:..:..|..|..|:...::.:.|
Worm  1169 NRSENCQKL--------MIMAVILLEDAMWSTTQSILSQGNLEERQWGSLTKDEEMLCKLTQMLG 1225

  Fly  1552 CVMPMGECIPPRTTALA-----ASTFHLYVS-----LASLDVNTFQETLTVEGPLSLKLLDVMTV 1606
            .:....|....|.|.::     :|..|:.::     |.|:..:..:...||    :.||:|.:
Worm  1226 NLADGMEHWQKRCTMISWTGGRSSCLHILINHIPIRLLSIGKHASRLVPTV----AEKLMDRL-- 1284

  Fly  1607 ILNCSLVNDQWTTNSESCPMLIDLVASMAF 1636
                        ||:|...:|.|:.|...|
Worm  1285 ------------TNAEKSEILGDMAAGWFF 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp3	NP_609917.2	SCAPER_N	113..208	CDD:293110
		FAM184	870..1060	CDD:292293	61/212 (29%)
		SPEC	991..1192	CDD:295325	79/300 (26%)
		GBP_C	<1111..1193	CDD:303769	33/178 (19%)
Y6B3B.4	NP_001364617.1	SCAPER_N	27..118	CDD:406813	16/91 (18%)
		PTZ00121	<393..668	CDD:173412	93/297 (31%)
		elast_bind_EbpS	<924..1035	CDD:411220	24/116 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163615
Domainoid	1	1.000	54	1.000	Domainoid score	I7582
eggNOG	1	0.900	-	-		E1_KOG4722
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006395
OrthoInspector	1	1.000	-	-		oto20789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR31434
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3307
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960