DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp3 and Scaper

DIOPT Version :9

Sequence 1:	NP_609917.2	Gene:	ssp3 / 35149	FlyBaseID:	FBgn0032723	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	XP_038938311.1	Gene:	Scaper / 117521	RGDID:	621585	Length:	1408	Species:	Rattus norvegicus

Alignment Length:	1859	Identity:	429/1859 - (23%)
Similarity:	674/1859 - (36%)	Gaps:	665/1859 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EMREVLSREGREAKNLLVYQFCDETTSSGATSGFGSTGGDVGGGSGGDG-PAVGSGGVLLNGDCY 65
            ::|.:::.|||.|:||:.:....|:...                   || |...:||
  Rat    13 KVRRIVAEEGRTARNLIAWSVPLESKDD-------------------DGKPKCQTGG-------- 50

  Fly    66 RKPPMVPPKSPNGTPKNCQSPTSPRLKSSASVGCGGGSSGGPRVRSAS---TGRDKKSELQARYW 127
                 ...::..||.|..:.  ......:.||.|...|:.|.:....|   |...:|.:|:||||
  Rat    51 -----KSKRTIQGTHKTTKQ--FHLFHQNTSVECKITSTTGEKHFDKSPTKTRHPRKIDLRARYW 108

  Fly   128 ALLFGNLQRAINEIYQTVECYENISSCQETILVLENYVRDFKALCEWFKVSWDYESRPLQQRPQS 192
            |.||.||:||::|||.|.|..:::..|:|.:::|:.||||||||.:|.::....|....|.||.|
  Rat   109 AFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDYYVRDFKALIDWIQLQEKLEKTDAQSRPTS 173

  Fly   193 LAWEVRKSNPTPRVRTRSLCSPNNSGKSSPALFPGTQSGETSPFCDNGQISPRKLLRAYDQVPKG 257
            |||||:|.:|...|    :.||:
  Rat   174 LAWEVKKMSPGRHV----IQSPS------------------------------------------ 192

  Fly   258 AMRLNVRELFAASKRATQGSSQSDNMEGPLDLSGDKSNFVLRSTQYAQTDLEDPHLTLADVREKM 322
            |.|:||
  Rat   193 ADRMNV----------------------------------------------------------- 198

  Fly   323 RMEAEEREAQNRIENEALEEVTIPIDNEDATESLNKQEPSSLELPIHNVADLSKEPELMEAASEA 387
                                      ...|..|||
  Rat   199 --------------------------TSTARRSLN------------------------------ 207

  Fly   388 TALEMTVASLESMENALLNQQANKEPTPPSTVIKPLAEILKKPQPLNPLSGNNVQNSPLKYSSVL 452
                                                             .||
  Rat   208 -------------------------------------------------FGN------------- 210

  Fly   453 NRPSKKMIPPPGGVAAQKTISTKPGLVKPNLTTTVNGLRSTKTATAPPAIKTTGRSGLQRHPRPS 517
                     .||.|.|                               |.:..||.|...:
  Rat   211 ---------LPGAVTA-------------------------------PCLAPTGVSWADK----- 230

  Fly   518 SKTECYGPPNNVASRLSARSRTMLEINGRNTNSSAR--TLPKKTNPGSILSTATRTKMSSRLSSR 580
                                     :...:|.||..  |..:...|.::..|       ||.:.|
  Rat   231 -------------------------VKAHHTGSSTSEVTAAQPCAPMAVQKT-------SRKNER 263

  Fly   581 EDITSSTSTLKASNEQLSNSRNTLKAENQHSEPKQIQPPTDADDGWLTVKNRRRTSMHWANRFNQ 645
            :|.                                        :||.||:..|..         :
  Rat   264 KDA----------------------------------------EGWETVQRGRPV---------R 279

  Fly   646 PTGYASLPTLALLNEQQKEQEHKEKQKGEDDGKVIVKTISAKTKAPIEVAKAKAKTSIVITRPEI 710
            ....|.:|.::|:.|..:.::..:|:.                               :...||.
  Rat   280 SRSTAVMPKVSLVTEALRAKDDSDKEN-------------------------------ICLLPEE 313

  Fly   711 KNAKAKVNSFPVQKSNTNQVKKPEKQEKSDTTAPAAIASSSNTRNSSHSICVGRNSIIKRQKSDL 775
            ...|.|    ||:                |..|||...|..:...|.|.:
  Rat   314 SIQKGK----PVE----------------DRCAPAESPSKDSLHPSDHPL--------------- 343

  Fly   776 TGLKMTSLHKEYMRSEKNALRKLQQKEQGNQQHNSSSSSAETVVESCNEDHSKIDIKIQTNCEF- 839
                     .|.::...:.|..:  |..|:.|.||..:|.   :.:.:.|...:.:..||....
  Rat   344 ---------SERIQFTVSILDDV--KNSGSSQDNSVHTSE---IPAIHSDVVCVAVTPQTTTALP 394

  Fly   840 -------SKTIGELYESIAHCKLPSGSLKTNASTLSACD-------ENEEQNTDDNEEERNERIL 890
                   ::|:|.:.|:..    ||     :.|.:||.|       ..:|:..|..|:...|.|.
  Rat   395 TDKDRVPAETVGMVTETTD----PS-----DISNVSAADWSMAEVLAKKEELADRLEKANEEAIA 450

  Fly   891 GEV--QESLERQIRELEQTEIDVDTETDETDCEVQLEEQDDGVDGLEMGSGDDSAVFVTMSDDEN 953
            ..:  :|.|.|:|...|..:|:::|:.| :|...            .||||  |..|..||.|.|
  Rat   451 SAIAEEEQLTREIEAEENNDINIETDND-SDFSA------------SMGSG--SLSFCGMSLDWN 500

  Fly   954 ---ASLELRYQALLSDMSWNERAEALATLQAYVARHPGRAQELHQKLSSPSRRRSLQETLKKYQA 1015
               |..|.| ::...:.||.:      .::...||.||....:|:|||||||:|::.|:.|||:.
  Rat   501 DVLADYEAR-ESWRQNTSWGD------IVEEEPARLPGHGIHMHEKLSSPSRKRTIAESKKKYEE 558

  Fly  1016 KQARAQQKRNLLQQEKAAKLQQLFSRVEDVKAAKNQIIEDKRQKMQGRLQRAAENREQYLKQIIE 1080
            |..:|||.|..|::||:.|||:|..|.:||:..|.::::.:|:.|:.:|..|...||..|:.|::
  Rat   559 KHMKAQQLREKLREEKSLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVK 623

  Fly  1081 KAHDEEKKLKEINFIKNIEAQNKRLDLLESSKETEGRLQDLEQERQKRVEEKLAKEAAVERRRQA 1145
            ||.:||.|:.||.||..:||||||.|:|...||.|.||.:|::|||:|.|||.|::.||:.|::|
  Rat   624 KAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRA 688

  Fly  1146 LEKERLLKLEKMNETRLEKEQRIGKMQEQKEKQRQALAREKARDREERLLALQVQQQQTTEELQR 1210
            ||.||..::|::...|.|:|.||.:.:::|||.|:..|||:||||||||.||...||:..||||:
  Rat   689 LEAERQARVEELLTKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQK 753

  Fly  1211 KILQKQMESARRHEENIEHIRQRALELT------------------------------------- 1238
            ||..|..||.|||.|.||..:::|.||:
  Rat   754 KIQLKHDESIRRHMEQIEQRKEKAAELSSGRHASTDYAPKLTPYERKKQCSLCNVLIASEVYLFS 818

  Fly  1239 ----------IPTRQADEGR--GDQDVSEDILNGNATSTTNEDCDLSSSLSEVGGNNAHTRSYKK 1291
                      :....:.:||  .|::|....|.........|    |::..|...:....:..||
  Rat   819 HIKGKKHQQAVRENSSIQGRELSDEEVEHLSLKKYVVDIVIE----SAAPPEPMKDGEERQKNKK 879

  Fly  1292 KMKKLKQRMNQCAAEYLESLEA------LPAHARRDSTVPKLL-NLVVKGGG------AQGLDRN 1343
            |.||:|.|||..|.||..|:|.      .|..|:.......|: .|.|:..|      |..|||.
  Rat   880 KAKKIKARMNTRAKEYENSVETKNSGSESPYKAKLQRLAKDLVKQLQVQDSGSWVNNKASALDRT 944

  Fly  1344 LGNLLRVIPKAQTLDFLAFLCMDGLGILAN--HVISKGMDEN--SEISRKSVYLAAQLYRNACSV 1404
            ||.:.|::.|....|.:||....||..|.|  .|::...:.|  |.|..||:..|..:|...||.
  Rat   945 LGEIARILEKENVADQIAFQVAGGLTALENILQVVAPATNMNTVSRIPPKSLCNAINVYNLTCSN 1009

  Fly  1405 CPQIARHALLGNSITVLFDAI--NKSFQLPEEK--------SPQHPVELSTELMLACTEALSSSY 1459
            |.:.....|..|.||.|.|.:  ..:..:|:|.        :.|....|:|.|:.|.....|...
  Rat  1010 CSENCTDVLFSNKITFLMDLLIHQLTVYIPDENNAVLGRNTNKQVFEGLTTGLLRAGAVVFSCLI 1074

  Fly  1460 VKK---NTHPKVPE------------------RLPDMINYAVITGLIEILSRRIQKVRESIESNK 1503
            ..:   |:.|..|:                  |:.|:|:|.|..|||:.|......|:..::.|.
  Rat  1075 ANRPDGNSRPATPKISTQEMKNKPSQGDAFNSRVQDLISYVVNMGLIDRLRGCFLSVQGPVDENP 1139

  Fly  1504 SVMLSLLTTLGFLSRFIDVC-----------QPGPADPTRLLSAAKSTELFGTVSMLYGCVMPMG 1557
            .:...|....|||.....:|           .....|||.|.:|.::|:|.|.:.||| |::..|
  Rat  1140 KMATFLQHAAGFLRGICMLCFTVTGRSSSIFDSNHQDPTGLTAALQATDLAGVLHMLY-CILFHG 1203

  Fly  1558 ----------ECIPPRTTALAASTFHLYVSLASLDVNTFQETLTVEGPLSLKLLDVMTVIL-NCS 1611
                      |.....|..:|..:...:.|.|.||::.||..:..|| |||....:.:.:| :||
  Rat  1204 TISDASTSPKESYTQNTIQVAIQSLRFFNSFAVLDLSAFQSIVGAEG-LSLAFRHMASSLLGHCS 1267

  Fly  1612 LVNDQWTTNSESCPMLI-DLVASMAFFCVNNRRHQDLLISEQYAVIFKRMAKLPTQF--NP---- 1669
            .|         ||..|: :::..:.:|.||:..:|.::.|.::..:.:::.:||.|:  :|
  Rat  1268 QV---------SCESLLHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIK 1323

  Fly  1670 VIYPFLVTVSFNNPPAREFLSKDFD----LTFLDEYSKS 1704
            |::|.|:....||...:..|.::..    .||:.:::::
  Rat  1324 VLFPSLIAACHNNHQNKLILEQEMSCVLLATFIQDFAQT 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp3	NP_609917.2	SCAPER_N	113..208	CDD:293110	45/97 (46%)
		FAM184	870..1060	CDD:292293	64/201 (32%)
		SPEC	991..1192	CDD:295325	93/200 (47%)
		GBP_C	<1111..1193	CDD:303769	40/81 (49%)
Scaper	XP_038938311.1	SCAPER_N	94..191	CDD:406813	44/100 (44%)
Scaper	XP_038938311.1	PTZ00121	<538..924	CDD:173412	143/389 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348855
Domainoid	1	1.000	96	1.000	Domainoid score	I7203
eggNOG	1	0.900	-	-		E1_KOG4722
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1612
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D51626at33208
OrthoFinder	1	1.000	-	-		FOG0006395
OrthoInspector	1	1.000	-	-		oto98018
orthoMCL	1	0.900	-	-		OOG6_106354
Panther	1	1.100	-	-	LDO	PTHR31434
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5352
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800