Protein Alignment ssp3 and Scaper

DIOPT Version :10

• Sequence 1: NP_609917.2
• Gene: ssp3 / 35149
• FlyBaseID: FBgn0032723
• Length: 1732
• Species: Drosophila melanogaster
• Sequence 2: XP_038938311.1
• Gene: Scaper / 117521
• RGDID: 621585
• Length: 1408
• Species: Rattus norvegicus
• Alignment Length: 1859
• Identity: 429/1859 - (23%)
• Similarity: 674/1859 - (36%)
• Gaps: 665/1859 - (35%)

  Fly     2 EMREVLSREGREAKNLLVYQFCDETTSSGATSGFGSTGGDVGGGSGGDG-PAVGSGGVLLNGDCY 65
            ::|.:::.|||.|:||:.:....|:...                   || |...:||
  Rat    13 KVRRIVAEEGRTARNLIAWSVPLESKDD-------------------DGKPKCQTGG-------- 50

  Fly    66 RKPPMVPPKSPNGTPKNCQSPTSPRLKSSASVGCGGGSSGGPRVRSAS---TGRDKKSELQARYW 127
                 ...::..||.|..:.  ......:.||.|...|:.|.:....|   |...:|.:|:||||
  Rat    51 -----KSKRTIQGTHKTTKQ--FHLFHQNTSVECKITSTTGEKHFDKSPTKTRHPRKIDLRARYW 108

  Fly   128 ALLFGNLQRAINEIYQTVECYENISSCQETILVLENYVRDFKALCEWFKVSWDYESRPLQQRPQS 192
            |.||.||:||::|||.|.|..:::..|:|.:::|:.||||||||.:|.::....|....|.||.|
  Rat   109 AFLFDNLRRAVDEIYVTCESDQSVVECKEVLMMLDYYVRDFKALIDWIQLQEKLEKTDAQSRPTS 173

  Fly   193 LAWEVRKSNPTPRVRTRSLCSPNNSGKSSPALFPGTQSGETSPFCDNGQISPRKLLRAYDQVPKG 257
            |||||:|.:|...|    :.||:
  Rat   174 LAWEVKKMSPGRHV----IQSPS------------------------------------------ 192

  Fly   258 AMRLNVRELFAASKRATQGSSQSDNMEGPLDLSGDKSNFVLRSTQYAQTDLEDPHLTLADVREKM 322
            |.|:||
  Rat   193 ADRMNV----------------------------------------------------------- 198

  Fly   323 RMEAEEREAQNRIENEALEEVTIPIDNEDATESLNKQEPSSLELPIHNVADLSKEPELMEAASEA 387
                                      ...|..|||
  Rat   199 --------------------------TSTARRSLN------------------------------ 207

  Fly   388 TALEMTVASLESMENALLNQQANKEPTPPSTVIKPLAEILKKPQPLNPLSGNNVQNSPLKYSSVL 452
                                                             .||
  Rat   208 -------------------------------------------------FGN------------- 210

  Fly   453 NRPSKKMIPPPGGVAAQKTISTKPGLVKPNLTTTVNGLRSTKTATAPPAIKTTGRSGLQRHPRPS 517
                     .||.|.|                               |.:..||.|...:
  Rat   211 ---------LPGAVTA-------------------------------PCLAPTGVSWADK----- 230

  Fly   518 SKTECYGPPNNVASRLSARSRTMLEINGRNTNSSAR--TLPKKTNPGSILSTATRTKMSSRLSSR 580
                                     :...:|.||..  |..:...|.::..|       ||.:.|
  Rat   231 -------------------------VKAHHTGSSTSEVTAAQPCAPMAVQKT-------SRKNER 263

  Fly   581 EDITSSTSTLKASNEQLSNSRNTLKAENQHSEPKQIQPPTDADDGWLTVKNRRRTSMHWANRFNQ 645
            :|.                                        :||.||:..|..         :
  Rat   264 KDA----------------------------------------EGWETVQRGRPV---------R 279

  Fly   646 PTGYASLPTLALLNEQQKEQEHKEKQKGEDDGKVIVKTISAKTKAPIEVAKAKAKTSIVITRPEI 710
            ....|.:|.::|:.|..:.::..:|:.                               :...||.
  Rat   280 SRSTAVMPKVSLVTEALRAKDDSDKEN-------------------------------ICLLPEE 313

  Fly   711 KNAKAKVNSFPVQKSNTNQVKKPEKQEKSDTTAPAAIASSSNTRNSSHSICVGRNSIIKRQKSDL 775
            ...|.|    ||:                |..|||...|..:...|.|.:
  Rat   314 SIQKGK----PVE----------------DRCAPAESPSKDSLHPSDHPL--------------- 343

  Fly   776 TGLKMTSLHKEYMRSEKNALRKLQQKEQGNQQHNSSSSSAETVVESCNEDHSKIDIKIQTNCEF- 839
                     .|.::...:.|..:  |..|:.|.||..:|.   :.:.:.|...:.:..||....
  Rat   344 ---------SERIQFTVSILDDV--KNSGSSQDNSVHTSE---IPAIHSDVVCVAVTPQTTTALP 394

  Fly   840 -------SKTIGELYESIAHCKLPSGSLKTNASTLSACD-------ENEEQNTDDNEEERNERIL 890
                   ::|:|.:.|:..    ||     :.|.:||.|       ..:|:..|..|:...|.|.
  Rat   395 TDKDRVPAETVGMVTETTD----PS-----DISNVSAADWSMAEVLAKKEELADRLEKANEEAIA 450

  Fly   891 GEV--QESLERQIRELEQTEIDVDTETDETDCEVQLEEQDDGVDGLEMGSGDDSAVFVTMSDDEN 953
            ..:  :|.|.|:|...|..:|:::|:.| :|...            .||||  |..|..||.|.|
  Rat   451 SAIAEEEQLTREIEAEENNDINIETDND-SDFSA------------SMGSG--SLSFCGMSLDWN 500

  Fly   954 ---ASLELRYQALLSDMSWNERAEALATLQAYVARHPGRAQELHQKLSSPSRRRSLQETLKKYQA 1015
               |..|.| ::...:.||.:      .::...||.||....:|:|||||||:|::.|:.|||:.
  Rat   501 DVLADYEAR-ESWRQNTSWGD------IVEEEPARLPGHGIHMHEKLSSPSRKRTIAESKKKYEE 558

  Fly  1016 KQARAQQKRNLLQQEKAAKLQQLFSRVEDVKAAKNQIIEDKRQKMQGRLQRAAENREQYLKQIIE 1080
            |..:|||.|..|::||:.|||:|..|.:||:..|.::::.:|:.|:.:|..|...||..|:.|::
  Rat   559 KHMKAQQLREKLREEKSLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVK 623

  Fly  1081 KAHDEEKKLKEINFIKNIEAQNKRLDLLESSKETEGRLQDLEQERQKRVEEKLAKEAAVERRRQA 1145
            ||.:||.|:.||.||..:||||||.|:|...||.|.||.:|::|||:|.|||.|::.||:.|::|
  Rat   624 KAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRA 688

  Fly  1146 LEKERLLKLEKMNETRLEKEQRIGKMQEQKEKQRQALAREKARDREERLLALQVQQQQTTEELQR 1210
            ||.||..::|::...|.|:|.||.:.:::|||.|:..|||:||||||||.||...||:..||||:
  Rat   689 LEAERQARVEELLTKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQK 753

  Fly  1211 KILQKQMESARRHEENIEHIRQRALELT------------------------------------- 1238
            ||..|..||.|||.|.||..:::|.||:
  Rat   754 KIQLKHDESIRRHMEQIEQRKEKAAELSSGRHASTDYAPKLTPYERKKQCSLCNVLIASEVYLFS 818

  Fly  1239 ----------IPTRQADEGR--GDQDVSEDILNGNATSTTNEDCDLSSSLSEVGGNNAHTRSYKK 1291
                      :....:.:||  .|::|....|.........|    |::..|...:....:..||
  Rat   819 HIKGKKHQQAVRENSSIQGRELSDEEVEHLSLKKYVVDIVIE----SAAPPEPMKDGEERQKNKK 879

  Fly  1292 KMKKLKQRMNQCAAEYLESLEA------LPAHARRDSTVPKLL-NLVVKGGG------AQGLDRN 1343
            |.||:|.|||..|.||..|:|.      .|..|:.......|: .|.|:..|      |..|||.
  Rat   880 KAKKIKARMNTRAKEYENSVETKNSGSESPYKAKLQRLAKDLVKQLQVQDSGSWVNNKASALDRT 944

  Fly  1344 LGNLLRVIPKAQTLDFLAFLCMDGLGILAN--HVISKGMDEN--SEISRKSVYLAAQLYRNACSV 1404
            ||.:.|::.|....|.:||....||..|.|  .|::...:.|  |.|..||:..|..:|...||.
  Rat   945 LGEIARILEKENVADQIAFQVAGGLTALENILQVVAPATNMNTVSRIPPKSLCNAINVYNLTCSN 1009

  Fly  1405 CPQIARHALLGNSITVLFDAI--NKSFQLPEEK--------SPQHPVELSTELMLACTEALSSSY 1459
            |.:.....|..|.||.|.|.:  ..:..:|:|.        :.|....|:|.|:.|.....|...
  Rat  1010 CSENCTDVLFSNKITFLMDLLIHQLTVYIPDENNAVLGRNTNKQVFEGLTTGLLRAGAVVFSCLI 1074

  Fly  1460 VKK---NTHPKVPE------------------RLPDMINYAVITGLIEILSRRIQKVRESIESNK 1503
            ..:   |:.|..|:                  |:.|:|:|.|..|||:.|......|:..::.|.
  Rat  1075 ANRPDGNSRPATPKISTQEMKNKPSQGDAFNSRVQDLISYVVNMGLIDRLRGCFLSVQGPVDENP 1139

  Fly  1504 SVMLSLLTTLGFLSRFIDVC-----------QPGPADPTRLLSAAKSTELFGTVSMLYGCVMPMG 1557
            .:...|....|||.....:|           .....|||.|.:|.::|:|.|.:.||| |::..|
  Rat  1140 KMATFLQHAAGFLRGICMLCFTVTGRSSSIFDSNHQDPTGLTAALQATDLAGVLHMLY-CILFHG 1203

  Fly  1558 ----------ECIPPRTTALAASTFHLYVSLASLDVNTFQETLTVEGPLSLKLLDVMTVIL-NCS 1611
                      |.....|..:|..:...:.|.|.||::.||..:..|| |||....:.:.:| :||
  Rat  1204 TISDASTSPKESYTQNTIQVAIQSLRFFNSFAVLDLSAFQSIVGAEG-LSLAFRHMASSLLGHCS 1267

  Fly  1612 LVNDQWTTNSESCPMLI-DLVASMAFFCVNNRRHQDLLISEQYAVIFKRMAKLPTQF--NP---- 1669
            .|         ||..|: :::..:.:|.||:..:|.::.|.::..:.:::.:||.|:  :|
  Rat  1268 QV---------SCESLLHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIK 1323

  Fly  1670 VIYPFLVTVSFNNPPAREFLSKDFD----LTFLDEYSKS 1704
            |::|.|:....||...:..|.::..    .||:.:::::
  Rat  1324 VLFPSLIAACHNNHQNKLILEQEMSCVLLATFIQDFAQT 1362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ssp3	NP_609917.2	SCAPER_N	113..208	CDD:406813	45/97 (46%)
		Smc	878..>1192	CDD:440809	125/318 (39%)
Scaper	XP_038938311.1	SCAPER_N	94..191	CDD:406813	44/100 (44%)
		PTZ00121	<446..>961	CDD:173412	186/540 (34%)
		Smc	<546..>794	CDD:440809	111/247 (45%)