DRSC/TRiP Functional Genomics Resources

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Protein Alignment tup and ISL2

DIOPT Version :9

Sequence 1:NP_001286068.1 Gene:tup / 35147 FlyBaseID:FBgn0003896 Length:534 Species:Drosophila melanogaster
Sequence 2:NP_665804.1 Gene:ISL2 / 64843 HGNCID:18524 Length:359 Species:Homo sapiens


Alignment Length:381 Identity:204/381 - (53%)
Similarity:245/381 - (64%) Gaps:43/381 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 VMNHHLDLDCHGHDVIKKQRLSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTC 95
            ::.|:..|...|....||...:.|||||.|||||:||||:||||||||||||.||.|:|||:|||
Human     4 IIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTC 68

  Fly    96 FVRDGKTYCKRDYVRLFGTKCDKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALR 160
            ||||||||||||||||||.||.||...||.:|.||||:..::||||||||.|:|||||||||:||
Human    69 FVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLR 133

  Fly   161 DAGALYCKEDHD-VLEKSSQSSLTSSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESGS 224
            : ..|.|:.||. :||:::..|..|......             :...|..:.||..........
Human   134 E-HELLCRADHGLLLERAAAGSPRSPGPLPG-------------ARGLHLPDAGSGRQPALRPHV 184

  Fly   225 HKSIRDKRPSGPSDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWF 289
            ||...          |.|||||||||||||||||||.|||||||||||||||||.||||||||||
Human   185 HKQTE----------KTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWF 239

  Fly   290 QNKRCKDKKKTIQMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQPPWKA 354
            ||||||||||:|.|| |:||::...|.....:.|.|::|.||:||::.:....::||||||||||
Human   240 QNKRCKDKKKSILMK-QLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKA 303

  Fly   355 LSDFALHADLDSNGAINTHTPAFQQLVN--------QMHGYDLNGMPI-LPPHPHS 401
            ||:|||.:|||.        |||||||:        ...|.|:..:.. ||..|:|
Human   304 LSEFALQSDLDQ--------PAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNS 351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tupNP_001286068.1 LIM1_Isl 54..108 CDD:188752 46/53 (87%)
LIM2_Isl 116..171 CDD:188760 32/54 (59%)
HOX 241..297 CDD:197696 52/55 (95%)
ISL2NP_665804.1 LIM1_Isl 27..81 CDD:188752 46/53 (87%)
LIM2_Isl2 89..143 CDD:188855 32/54 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 151..191 7/62 (11%)
HOX 191..247 CDD:197696 52/55 (95%)
LIM-binding domain (LID). /evidence=ECO:0000250 272..301 13/28 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 326..359 6/26 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159375
Domainoid 1 1.000 126 1.000 Domainoid score I5419
eggNOG 1 0.900 - - E33208_3BAXJ
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 401 1.000 Inparanoid score I1932
Isobase 1 0.950 - 0 Normalized mean entropy S3195
OMA 1 1.010 - - QHG45829
OrthoDB 1 1.010 - - D403874at33208
OrthoFinder 1 1.000 - - FOG0002096
OrthoInspector 1 1.000 - - otm42026
orthoMCL 1 0.900 - - OOG6_105408
Panther 1 1.100 - - LDO PTHR24204
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5473
SonicParanoid 1 1.000 - - X1777
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.750

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