Protein Alignment tup and LHX9

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: XP_011508083.2
• Gene: LHX9 / 56956
• HGNCID: 14222
• Length: 403
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 107/341 - (31%)
• Similarity: 163/341 - (47%)
• Gaps: 34/341 - (9%)

  Fly     7 GGHLAHQL-PLHNHNHNQTGLQPSLVMNHHLDLDCHGHDV----IKKQRLSHCVGCGGQIHDQYI 66
            |||:...: .:...:..:..|.....:|        |.|.    :..::.:.|.||||:|.|:|.
Human    33 GGHIQGIMEEMERRSKTEARLAKGAQLN--------GRDAGMPPLSPEKPALCAGCGGKISDRYY 89

  Fly    67 LRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGT-KCDKCGNSFSKNDFVM 130
            | :|.|.:||..||||.||:..|:...|||.:||..|||.||.|.|.. :|.:|....|.::.||
Human    90 L-LAVDKQWHLRCLKCCECKLALESELTCFAKDGSIYCKEDYYRRFSVQRCARCHLGISASEMVM 153

  Fly   131 RAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVL---EKSSQSSLTSSSVESNN- 191
            ||:..::|:.||.||.|.:.|..||.|.::|: .:||:...:.|   |...|.|.|..:.:|..
Human   154 RARDSVYHLSCFTCSTCNKTLTTGDHFGMKDS-LVYCRAHFETLLQGEYPPQLSYTELAAKSGGL 217

  Fly   192 NISSSNNNNT---NLSNNNHSSELG----SMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTVLN 249
            .:...|...|   .......|..||    :.:...:|:.:....||::|..||. |..|:||...
Human   218 ALPYFNGTGTVQKGRPRKRKSPALGVDIVNYNSGCNENEADHLDRDQQPYPPSQ-KTKRMRTSFK 281

  Fly   250 EKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKEGR 314
            ..||.|:::.:..|..|||...:||.:.|.|:.||::|||||.|.|.::..      ::||..|.
Human   282 HHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNL------LRQENGGV 340

  Fly   315 KLGYGAMQGIPMIASS 330
            ....|.....|..|.|
Human   341 DKADGTSLPAPPSADS 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	28/53 (53%)
		LIM2_Isl	116..171	CDD:188760	20/54 (37%)
		HOX	241..297	CDD:197696	23/55 (42%)
LHX9	XP_011508083.2	LIM1_Lhx2	67..130	CDD:188853	28/63 (44%)
		LIM2_Lhx2_Lhx9	135..193	CDD:188763	20/58 (34%)
		Homeodomain	274..330	CDD:459649	23/55 (42%)