Protein Alignment tup and lmx1a

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_001020669.1
• Gene: lmx1a / 558036
• ZFINID: ZDB-GENE-041014-332
• Length: 366
• Species: Danio rerio
• Alignment Length: 438
• Identity: 126/438 - (28%)
• Similarity: 172/438 - (39%)
• Gaps: 127/438 - (28%)

  Fly    50 RLSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGT 114
            |.|.|.||...|.|:|:|||...| ||..||.|..||:.|.:  |||:|:...||||||.:||..
Zfish    22 RKSVCEGCNELIRDRYLLRVQDGL-WHERCLHCASCREPLKD--TCFLRNKTLYCKRDYQKLFVV 83

  Fly   115 KCDKCGNSFSKNDFVMRAK-TKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSS 178
            :|..|....|.::.||||: :.:||:.||.|..|..:|..||...||..|.......|:.|
Zfish    84 RCQGCSEIISPSELVMRAQGSAVFHLRCFCCCVCGCRLQKGDHCVLRGDGLFCATHFHNQL---- 144

  Fly   179 QSSLTSSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPSDGKPTR 243
             :|.|||....:.:|...|::..||.....|:..|.:        .||  |.|||
Zfish   145 -ASPTSSDSGKSEDIEEDNDDEDNLKTAGESNITGDV--------EHK--RPKRP---------- 188

  Fly   244 VRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQ 308
             ||:|..:|....:..:..:.:|...::|.|...|.||.||::|||||:|.|.||...:.:.|.|
Zfish   189 -RTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLVRRQQQQKQ 252

  Fly   309 ----QEKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQ-----TYQPPWKALSDFALHADL 364
                |||.                .||.:..:..:...|.|:     :|..|.:.||       |
Zfish   253 TVCPQEKR----------------ESPSQQHTATSCGALPVELECAGSYPLPQQNLS-------L 294

  Fly   365 DSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQQ 429
            ||           |.|.             |.|.                      .|...|.|.
Zfish   295 DS-----------QSLK-------------LDPF----------------------RQGLTPPQM 313

  Fly   430 PGGSSLDSGITSHHHPDSTDSYVTYLESD---------DKSKLA-LTP 467
            ||         .|.||...|:.....:||         ..|:|: |||
Zfish   314 PG---------DHMHPYGCDTLYDETDSDPLCHFGDCMSSSELSFLTP 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	26/53 (49%)
		LIM2_Isl	116..171	CDD:188760	19/55 (35%)
		HOX	241..297	CDD:197696	19/55 (35%)
lmx1a	NP_001020669.1	LIM1_Lmx1a	26..77	CDD:188756	26/53 (49%)
		LIM	84..140	CDD:413332	19/55 (35%)
		Homeodomain	186..242	CDD:459649	22/66 (33%)