Protein Alignment tup and LHX8

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: XP_016856805.1
• Gene: LHX8 / 431707
• HGNCID: 28838
• Length: 363
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 102/343 - (29%)
• Similarity: 153/343 - (44%)
• Gaps: 67/343 - (19%)

  Fly    54 CVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCDK 118
            |..||.:|.|:|:|:| .||.||..||.|..||..|....:|:::|...:||.||.|.:||:|.:
Human    65 CNSCGLEIVDKYLLKV-NDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSR 128

  Fly   119 CGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSLT 183
            ||......|:|.|||..::|:.||.|.:|.|||..|:||||.:...| |:..:|.:
Human   129 CGRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVL-CRVHYDCM--------- 183

  Fly   184 SSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTVL 248
                        .:|....:.|.|..|..|::.       :.:.:...:|:       .|.||..
Human   184 ------------LDNLKREVENGNGISVEGALL-------TEQDVNHPKPA-------KRARTSF 222

  Fly   249 NEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKEG 313
            ...||..::..:..:..|||...::|.|.|.||.|||:|||||.|.:.||
Human   223 TADQLQVMQAQFAQDNNPDAQTLQKLAERTGLSRRVIQVWFQNCRARHKK--------------- 272

  Fly   314 RKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQPPWKALSDFALHADL-DSNGAINTHTPA- 376
             .:........|:.|..|.|...|: |:.:....|.|....:.. |||:.: |::.|::.|.|.
Human   273 -HVSPNHSSSTPVTAVPPSRLSPPM-LEEMAYSAYVPQDGTMLT-ALHSYMDDTHAAVHIHLPGR 334

  Fly   377 ---FQQLVNQMHGYDLNG 391
               ||       ||..||
Human   335 MWRFQ-------GYSNNG 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	22/53 (42%)
		LIM2_Isl	116..171	CDD:188760	23/54 (43%)
		HOX	241..297	CDD:197696	22/55 (40%)
LHX8	XP_016856805.1	LIM1_Lhx7_Lhx8	64..119	CDD:188767	23/54 (43%)
		LIM2_Lhx7_Lhx8	126..180	CDD:188769	23/54 (43%)
		Homeodomain	216..272	CDD:459649	22/55 (40%)