Protein Alignment tup and LHX1

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_005559.2
• Gene: LHX1 / 3975
• HGNCID: 6593
• Length: 406
• Species: Homo sapiens
• Alignment Length: 467
• Identity: 144/467 - (30%)
• Similarity: 205/467 - (43%)
• Gaps: 102/467 - (21%)

  Fly    53 HCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCD 117
            ||.||...|.|:::|.|. |..||..|::|.||:..|.|.  ||.|:||.|||.|:.|.|||||.
Human     3 HCAGCKRPILDRFLLNVL-DRAWHVKCVQCCECKCNLTEK--CFSREGKLYCKNDFFRCFGTKCA 64

  Fly   118 KCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSL 182
            .|....|.:|.|.||::|:||:.||.|..|.:||..|:|..:.|.....||||:          |
Human    65 GCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDY----------L 119

  Fly   183 TSSSVESNNNI-SSSNNNNTNLSNNNH--------SSELGSMSD--SGSESGSHKSIRDKRPSGP 236
            ::|||...|:: |::..::.:||.::.        .||..::||  :||.....:::..|| .||
Human   120 SNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEAGSNENDDQNLGAKR-RGP 183

  Fly   237 SDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTI 301
                    ||.:..|||.||:..:.|.|:|...::|||.:.|.|:.|||:|||||:|.|:::
Human   184 --------RTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERR--- 237

  Fly   302 QMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRH---DSPLNLQGLDVQTYQPPWKALSDFALHAD 363
                 |:|                :.|....||   .||..::.| |...:|           .:
Human   238 -----MKQ----------------LSALGARRHAFFRSPRRMRPL-VDRLEP-----------GE 269

  Fly   364 LDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQ 428
            |..||..:.:.....:.......||     ..|..|.|..||.|......|..|
Human   270 LIPNGPFSFYGDYQSEYYGPGGNYD-----FFPQGPPSSQAQTPVDLPFVPSSG----------- 318

  Fly   429 QPGGSSLDSGITSH----HHPDS-----TDSYVTYLESDDKSKLALTPSSSSSASAGTSISSPP- 483
             |.|:.|  |...|    |||.|     || .:.:...|..|.....|....|.||.....|||
Human   319 -PSGTPL--GGLEHPLPGHHPSSEAQRFTD-ILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPF 379

  Fly   484 SGVGAGGGGAVG 495
            |.:...||.:.|
Human   380 SSLSVNGGASYG 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	24/53 (45%)
		LIM2_Isl	116..171	CDD:188760	22/54 (41%)
		HOX	241..297	CDD:197696	25/55 (45%)
LHX1	NP_005559.2	LIM1_Lhx1_Lhx5	4..55	CDD:188753	24/53 (45%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	22/54 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..187		16/67 (24%)
		Homeodomain	181..237	CDD:459649	27/63 (43%)
		dnaA	<263..>382	CDD:455861	35/149 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..374		27/100 (27%)