Protein Alignment tup and Lhx4

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_001101818.2
• Gene: Lhx4 / 360858
• RGDID: 1308044
• Length: 390
• Species: Rattus norvegicus
• Alignment Length: 460
• Identity: 121/460 - (26%)
• Similarity: 183/460 - (39%)
• Gaps: 141/460 - (30%)

  Fly    46 IKKQRLSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVR 110
            :..|::..|.||...|.|::||:|. |..||::||||.:|:..|.:  .||.|.|..|||.|:.:
  Rat    22 VPMQQIPQCAGCNQHILDKFILKVL-DRHWHSSCLKCADCQMQLAD--RCFSRAGSVYCKEDFFK 83

  Fly   111 LFGTKCDKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLE 175
            .|||||..|.........|.:|:..::|:.||.|..|.|||..||||.|.:.|.|.||||::.
  Rat    84 RFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYET-- 146

  Fly   176 KSSQSSLTSSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPSDGK 240
                                        :..|..||.|:                |||
  Rat   147 ----------------------------AKQNDDSEAGA----------------KRP------- 160

  Fly   241 PTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDK-------- 297
                ||.:..|||.||:..|..:|:|...::|||...|.|..||::|||||:|.|:|
  Rat   161 ----RTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGR 221

  Fly   298 -------KKTIQMKLQMQQEKEG--------------------RKLGY--------GAMQGIPMI 327
                   |...:.:...:||||.                    .:||:        |.:.|..::
  Rat   222 HRWGQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLM 286

  Fly   328 ASSPVRHDSPLNLQGLDVQTYQPPWKALSDFALHADLDSNGAINTHTPAFQQLVNQMHGYDL--- 389
            ..|       .::.|.. |:|| ..:..|.:.:.....|..::.:|.|.       :.|.|.
  Rat   287 NGS-------FSMDGTG-QSYQ-DLRDGSPYGIPQSPSSISSLPSHAPL-------LSGLDYTVD 335

  Fly   390 NGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQQPGGSSLDSGITSHHHPDSTDSYVTY 454
            :.:.::     :||.||.........|||             .|.|.:| :|..:||...|..::
  Rat   336 SNLGVI-----AHPGQGVSQTLRAMAGGP-------------TSDLSTG-SSVGYPDFPTSPASW 381

  Fly   455 LESDD 459
            |:..|
  Rat   382 LDEMD 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	24/53 (45%)
		LIM2_Isl	116..171	CDD:188760	22/54 (41%)
		HOX	241..297	CDD:197696	24/55 (44%)
Lhx4	NP_001101818.2	LIM1_Lhx4	30..81	CDD:188852	24/53 (45%)
		LIM2_Lhx3_Lhx4	89..144	CDD:188762	22/54 (41%)
		Homeodomain	158..214	CDD:459649	27/66 (41%)