Protein Alignment tup and Lim1

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_572505.1
• Gene: Lim1 / 31813
• FlyBaseID: FBgn0026411
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 556
• Identity: 145/556 - (26%)
• Similarity: 210/556 - (37%)
• Gaps: 158/556 - (28%)

  Fly    16 LHNHNHNQTGLQPSLVMNHHLDLDCHGHDVIKKQRLSHCVGCGGQIHDQYILRVAPDLEWHAACL 80
            ||...||....:|.:.:.                  ..|.||...|.|:::|.|. :..|||:|:
  Fly     7 LHTSQHNIGRSEPPVGVG------------------DPCAGCNKPILDKFLLNVL-ERAWHASCV 52

  Fly    81 KCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCDKCGNSFSKNDFVMRAKTKIFHIECFRCS 145
            :|.||.|.|.:.  ||.|:.|.||:.|:.|.:||||..||...:.:|.|.:.:.|:||:.||.|.
  Fly    53 RCCECLQPLTDK--CFSRESKLYCRNDFFRRYGTKCSGCGQGIAPSDLVRKPRDKVFHLNCFTCC 115

  Fly   146 ACARQLLPGDEFALRDAGALYCKEDHDVLEK-------SSQSSLTSSSVESNNNIS--------- 194
            .|.:||..|::..:.|.....||:|: :|.|       |...||..|:.|.:::..
  Fly   116 ICRKQLSTGEQLYVLDDNKFICKDDY-LLGKAPSCGHNSLSDSLMGSASEDDDDDDPPHLRATAL 179

  Fly   195 ----------------------SSNNNNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPS 237
                                  |..:.:|:..|.:..|:.||: |...:........:|.|...:
  Fly   180 GLGVLGPNGPDSAGGPLGTSDISVQSMSTDSKNTHDDSDQGSL-DGDPDGRGDSQAENKSPDDAN 243

  Fly   238 DGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQ 302
            ..|....||.:..|||..|:|.:|..|:|...::|||.:.|.|..|||:|||||||.|:::
  Fly   244 GSKRRGPRTTIKAKQLEVLKTAFNQTPKPTRHIREQLAKETGLPMRVIQVWFQNKRSKERR---- 304

  Fly   303 MKLQMQQEKEGRKLGYGA---MQGIPMIASSPVRHDSPLNLQ--GLDVQTYQPPWKALSDFALHA 362
            ||   |....||...:|.   |:|.||            ||.  |||
  Fly   305 MK---QITSMGRPPFFGGARKMRGFPM------------NLSPGGLD------------------ 336

  Fly   363 DLDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPN 427
              |..|     .|.|........||   |.|.   |||..|      ..|..||||      .|.
  Fly   337 --DGPG-----FPYFAADAKFEFGY---GGPF---HPHDGP------YFPGHPGGP------MPF 376

  Fly   428 QQPGGSSLDSGITSHHHPDSTDSYVTYLESDDKSKLALTPSSSSSASAG-------TSISSPPSG 485
            ..|||....||                 .....::..|||.::....||       :::..||..
  Fly   377 NAPGGPMDHSG-----------------PIPMVNEFGLTPEATFLGQAGGPPMQLQSAVGPPPPP 424

  Fly   486 VGAGGGGAVGGGSGVLGLGVVANQSATEQLMQMLQK 521
            ........:...:      ..|.|.|.:|..|..|:
  Fly   425 PPPSAEHLMAAAA------AAAQQQAAQQQQQQQQQ 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	22/53 (42%)
		LIM2_Isl	116..171	CDD:188760	18/54 (33%)
		HOX	241..297	CDD:197696	26/55 (47%)
Lim1	NP_572505.1	LIM1_Lhx1_Lhx5	27..78	CDD:188753	22/53 (42%)
		LIM2_Lhx1_Lhx5	86..141	CDD:188761	18/54 (33%)
		COG5576	185..324	CDD:227863	42/146 (29%)
		Homeodomain	248..304	CDD:459649	26/55 (47%)