Protein Alignment tup and lhx5

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_571293.1
• Gene: lhx5 / 30465
• ZFINID: ZDB-GENE-980526-484
• Length: 399
• Species: Danio rerio
• Alignment Length: 453
• Identity: 134/453 - (29%)
• Similarity: 192/453 - (42%)
• Gaps: 100/453 - (22%)

  Fly    53 HCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCD 117
            ||.||...|.|:::|.|. |..|||.|::|.||...|.|.  ||.||||.|||.|:.|.|||||.
Zfish     4 HCAGCERPILDRFLLNVL-DRAWHAKCVQCCECNCNLTEK--CFSRDGKLYCKIDFFRRFGTKCA 65

  Fly   118 KCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSL 182
            .|....|.:|.|.||::|:||:.||.|..|.:||..|:|..:.|.....||||:  |..|:...:
Zfish    66 GCLQGISPSDLVRRARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKEDY--LSASAIKEV 128

  Fly   183 TSSSVESNNNISSSNN------NNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPSDGKP 241
            ..:||.|..:.|.|.:      ::|..::|:.||:..:.::...|..|....|     ||
Zfish   129 NLNSVSSCTDRSLSPDLPDQIQDDTKETDNSTSSDKDTNNNENEEQNSCTKRR-----GP----- 183

  Fly   242 TRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQ 306
               ||.:..|||.||:..:.|.|:|...::|||.:.|.|:.|||:|||||:|.|:::
Zfish   184 ---RTTIKAKQLETLKAAFVATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERR-------- 237

  Fly   307 MQQEKEGRKLGYGAMQGIPMIASSPVRH---DSPLNLQGLDVQTYQPPWKALSDFALHADLDSNG 368
            |:|                :.|....||   ..|..::.|..:...|            |:...|
Zfish   238 MKQ----------------LSALGARRHAFFRGPRRMRPLGGRLEDP------------DIMGPG 274

  Fly   369 AINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQQP--- 430
                             ||...|       .:.....||...:...|.||.:.|...|.:.|
Zfish   275 -----------------GYSYYG-------EYQGDYYGPVVNYDFFPHGPPSSQAHSPAESPYLL 315

  Fly   431 --GGSSLDSGITSHHHPDSTDSYVTYLESDDKSKLALTPSSSSSASAGTSISSPPSGVGAGGG 491
              |..:|:.|..|.|||.....:...:...|      |||.....:.  .:.|.|.|.|...|
Zfish   316 SSGSGALEGGPVSAHHPSDDQRFTDMISHAD------TPSPEPGMTG--PLHSNPQGEGGFTG 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	26/53 (49%)
		LIM2_Isl	116..171	CDD:188760	22/54 (41%)
		HOX	241..297	CDD:197696	25/55 (45%)
lhx5	NP_571293.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	26/53 (49%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	22/54 (41%)
		COG5576	126..>242	CDD:227863	41/152 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..185		11/61 (18%)
		Homeodomain	181..237	CDD:459649	28/68 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..399		19/78 (24%)