Protein Alignment tup and lhx1a

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_571291.1
• Gene: lhx1a / 30463
• ZFINID: ZDB-GENE-980526-347
• Length: 405
• Species: Danio rerio
• Alignment Length: 461
• Identity: 141/461 - (30%)
• Similarity: 211/461 - (45%)
• Gaps: 85/461 - (18%)

  Fly    53 HCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCD 117
            ||.||...|.|:::|.|. |..||..|::|.||:..|.|.  ||.|:||.|||.|:.|.|||||.
Zfish     3 HCAGCERPILDRFLLNVL-DRAWHIKCVQCCECKCNLTEK--CFSREGKLYCKNDFFRRFGTKCA 64

  Fly   118 KCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSL 182
            .|....|.||.|.||::|:||:.||.|..|.:||..|:|..:.|.....||:|:........|:|
Zfish    65 GCAQGISPNDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKDDYLSNTNGKDSNL 129

  Fly   183 TSSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTV 247
            .|.:..|:.::|..:.:  .|.::...:|:.::||  .|:|::::  |.:..|   ||....||.
Zfish   130 LSVTACSDPSLSPDSQD--QLQDDVKDAEIANLSD--KETGNNEN--DDQNLG---GKRRGPRTT 185

  Fly   248 LNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKE 312
            :..|||.||:..:.|.|:|...::|||.:.|.|:.|||:|||||:|.|:::        |:|
Zfish   186 IKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERR--------MKQ--- 239

  Fly   313 GRKLGYGAMQGIPMIASSPVRH---DSPLNLQGLDVQTYQPPWKALSDFALHADLDSNGAINTHT 374
                         :.|....||   .||..::.| |...:|           .:|..||..:.:.
Zfish   240 -------------LSALGARRHAFFRSPRRMRTL-VDRLEP-----------GELIPNGPFSYYG 279

  Fly   375 PAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGP------PHQHP--PPPGG-----PHNHQNQQ- 425
            ....:.......||     ..|..|.|..||.|      |...|  .|.||     |.:|.:.:
Zfish   280 DYQSEYYGPGGNYD-----FFPQGPPSSQAQTPVDLPFVPSSGPTGTPLGGMDHPIPGHHPSSEV 339

  Fly   426 ------PNQQPGGS-SLDSGITSHHHPDSTDSYVTYLESDDKSKLALTPSSSSSASAGTSISSPP 483
                  .:..||.| |.:.||....|..|:|   .:..|...:.|:|..|..|:     .:|.||
Zfish   340 QRFSDIMSHHPGDSPSPEPGIPGPLHSMSSD---VFGPSPSFTSLSLNGSGYSN-----HLSHPP 396

  Fly   484 SGVGAG 489
            |.:..|
Zfish   397 SEMNEG 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	24/53 (45%)
		LIM2_Isl	116..171	CDD:188760	22/54 (41%)
		HOX	241..297	CDD:197696	25/55 (45%)
lhx1a	NP_571291.1	LIM1_Lhx1_Lhx5	4..55	CDD:188753	24/53 (45%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	22/54 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..184		8/32 (25%)
		Homeodomain	180..236	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	296..373		22/79 (28%)