DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tup and isl2a

DIOPT Version :9

Sequence 1:	NP_001286068.1	Gene:	tup / 35147	FlyBaseID:	FBgn0003896	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	XP_005163214.1	Gene:	isl2a / 30157	ZFINID:	ZDB-GENE-980526-562	Length:	360	Species:	Danio rerio

Alignment Length:	386	Identity:	207/386 - (53%)
Similarity:	248/386 - (64%)	Gaps:	52/386 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VMNHHLDLDCHGHDVIKKQRLSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTC 95
            ::.|...|...|....||..::.|||||.||||||||||:||||||||||||.||.|:|||:|||
Zfish     4 ILPHPSFLGDMGDHSKKKSGIAMCVGCGSQIHDQYILRVSPDLEWHAACLKCAECSQYLDETCTC 68

  Fly    96 FVRDGKTYCKRDYVRLFGTKCDKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALR 160
            ||||||||||||||||||.||.||...|..:|.||||:..::|:||||||.|:|.|||||||:||
Zfish    69 FVRDGKTYCKRDYVRLFGIKCAKCNIGFCSSDLVMRARDNVYHMECFRCSVCSRHLLPGDEFSLR 133

  Fly   161 DAGALYCKEDHDVL-EKSSQSSLTSSSVESNNNISSSN-----NNNTNLSNNNHSSELGSMSDSG 219
            |. .|.|:.||.:| |::|     :.|..|..||.||.     .....:....|.:.:...|:
Zfish   134 DE-ELLCRADHGLLMERAS-----AGSPISPGNIHSSRPLHIPGKPVPVRQPPHRNHVHKQSE-- 190

  Fly   220 SESGSHKSIRDKRPSGPSDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRV 284
                                |.|||||||||||||||||||||||||||||||||||||.|||||
Zfish   191 --------------------KTTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTGLSPRV 235

  Fly   285 IRVWFQNKRCKDKKKTIQMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQ 349
            |||||||||||||||:|.|| |:||::...|.....:.|.|::|.||:|||:.:....::|||||
Zfish   236 IRVWFQNKRCKDKKKSILMK-QLQQQQHNDKTNLQGLTGTPLVAGSPIRHDTTVQGNPVEVQTYQ 299

  Fly   350 PPWKALSDFALHADLDSNGAINTHTPAFQQLVN--------QMHGYDLNGMPI-LPPHPHS 401
            |||||||:|||.:|||.        |||||||:        ...|.|:..:.. ||..|:|
Zfish   300 PPWKALSEFALQSDLDQ--------PAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNS 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_001286068.1	LIM1_Isl	54..108	CDD:188752	47/53 (89%)
		LIM2_Isl	116..171	CDD:188760	30/54 (56%)
		HOX	241..297	CDD:197696	53/55 (96%)
isl2a	XP_005163214.1	LIM1_Isl	27..81	CDD:188752	47/53 (89%)
		LIM2_Isl	89..143	CDD:188760	30/54 (56%)
		HOX	192..248	CDD:197696	53/55 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595531
Domainoid	1	1.000	126	1.000	Domainoid score	I5343
eggNOG	1	0.900	-	-		E33208_3BAXJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	403	1.000	Inparanoid score	I1876
OMA	1	1.010	-	-		QHG45829
OrthoDB	1	1.010	-	-		D403874at33208
OrthoFinder	1	1.000	-	-		FOG0002096
OrthoInspector	1	1.000	-	-		otm25849
orthoMCL	1	0.900	-	-		OOG6_105408
Panther	1	1.100	-	-	LDO	PTHR24204
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5473
SonicParanoid	1	1.000	-	-		X1777
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800