Protein Alignment tup and Lmx1a

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_001099437.2
• Gene: Lmx1a / 289201
• RGDID: 1304784
• Length: 382
• Species: Rattus norvegicus
• Alignment Length: 431
• Identity: 121/431 - (28%)
• Similarity: 180/431 - (41%)
• Gaps: 110/431 - (25%)

  Fly    52 SHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKC 116
            |.|.||...|.|:::||: .|..||..|::|..|::.|:  .|||.||.|.|||..|.:||..||
  Rat    33 SVCEGCQRVISDRFLLRL-NDSFWHEQCVQCASCKEPLE--TTCFYRDKKLYCKYHYEKLFAVKC 94

  Fly   117 DKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSS 181
            ..|..:.:.|:|||||:..::|:.||.|..|.|||..||||.|:: |.|.||.|::  ::....|
  Rat    95 GGCFEAIAPNEFVMRAQKSVYHLSCFCCCVCERQLQKGDEFVLKE-GQLLCKGDYE--KERELLS 156

  Fly   182 LTSSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESG-SHKSIRDKRPSGPSDGKPTRVR 245
            |.|.:...    |..:::..:|..:.|.:..|:     ||.| .||  |.|||           |
  Rat   157 LVSPAASD----SGKSDDEESLCKSAHGAGKGA-----SEDGKDHK--RPKRP-----------R 199

  Fly   246 TVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQE 310
            |:|..:|....:..:..:.:|...::|.|...|.||.||::|||||:|.|.||...:.:.|.|.:
  Rat   200 TILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQQDQ 264

  Fly   311 KEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQPPWKALSDFALHADLDSNGAINTHT- 374
            :..::|......|                                     ..:....|.:|.:|
  Rat   265 QNTQRLSSAQTNG-------------------------------------SGNAGMEGIMNPYTT 292

  Fly   375 -PAFQQLV---NQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQQPGGSSL 435
             |..|||:   ..::..|                  |..|...||            |.||
  Rat   293 LPTPQQLLAIEQSVYNSD------------------PFRQGLTPP------------QMPG---- 323

  Fly   436 DSGITSHHHPDSTDSYVTYLESDDKSKLALTPSSSSSASAG 476
                 .|.||...:.....|:|||.|...|.....:::.||
  Rat   324 -----DHMHPYGAEPLFHDLDSDDTSLSNLGDCFLATSEAG 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	23/53 (43%)
		LIM2_Isl	116..171	CDD:188760	25/54 (46%)
		HOX	241..297	CDD:197696	19/55 (35%)
Lmx1a	NP_001099437.2	LIM1_Lmx1a	35..86	CDD:188756	23/53 (43%)
		LIM2_Lmx1a_Lmx1b	94..148	CDD:188764	25/54 (46%)
		Homeodomain	196..252	CDD:459649	22/66 (33%)