Protein Alignment tup and LHX6

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_055183.2
• Gene: LHX6 / 26468
• HGNCID: 21735
• Length: 392
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 97/326 - (29%)
• Similarity: 149/326 - (45%)
• Gaps: 64/326 - (19%)

  Fly    54 CVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCDK 118
            |..||.:|.|:|:|:| .:|.||..||:|..||..|.:..:|::::.:.:||.||...|||||.:
Human    99 CSSCGLEILDRYLLKV-NNLIWHVRCLECSVCRTSLRQQNSCYIKNKEIFCKMDYFSRFGTKCAR 162

  Fly   119 CGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSLT 183
            ||.....:|:|.||:...:|:.||.|.:|.|||..|:||.|.:...| |:..:|.:
Human   163 CGRQIYASDWVRRARGNAYHLACFACFSCKRQLSTGEEFGLVEEKVL-CRIHYDTM--------- 217

  Fly   184 SSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRPSGPSDGKPT-RVRTV 247
               :| |...::.|.|...|                  .|:..|.:|.:|      ||. |.||.
Human   218 ---IE-NLKRAAENGNGLTL------------------EGAVPSEQDSQP------KPAKRARTS 254

  Fly   248 LNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKE 312
            ...:||..::..:..:..|||...::|.:||.||.|||:|||||.|.:.||.|.|
Human   255 FTAEQLQVMQAQFAQDNNPDAQTLQKLADMTGLSRRVIQVWFQNCRARHKKHTPQ---------- 309

  Fly   313 GRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQPPWKALSDFALHADLDSN---GAINTHT 374
                     ..:|...:.|.|..|.|: ..:....:..|.:|.. ..||..::|.   |.::...
Human   310 ---------HPVPPSGAPPSRLPSALS-DDIHYTPFSSPERARM-VTLHGYIESQVQCGQVHCRL 363

  Fly   375 P 375
            |
Human   364 P 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	20/53 (38%)
		LIM2_Isl	116..171	CDD:188760	21/54 (39%)
		HOX	241..297	CDD:197696	23/56 (41%)
LHX6	NP_055183.2	LIM1_Lhx6	99..152	CDD:188766	20/53 (38%)
		LIM2_Lhx6	160..214	CDD:188768	21/54 (39%)
		Homeodomain	249..305	CDD:459649	22/55 (40%)