Protein Alignment tup and lin-11

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_492696.1
• Gene: lin-11 / 172893
• WormBaseID: WBGene00003000
• Length: 405
• Species: Caenorhabditis elegans
• Alignment Length: 421
• Identity: 119/421 - (28%)
• Similarity: 176/421 - (41%)
• Gaps: 85/421 - (20%)

  Fly    15 PLHNHNHNQ--------------------TGLQPSLVMNHHLDLDCHGHDVIKKQRLSHCVGCGG 59
            |.| |.|.|                    |.:.||.....|:. :..|::         |..|..
 Worm    20 PAH-HLHQQSIEDVGSVTSSATLLLLDSATWMMPSSTTQPHIS-EISGNE---------CAACAQ 73

  Fly    60 QIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCDKCGNSFS 124
            .|.|:|:..|.... ||.:||:|.:||..:  |.|||.|||...||.|:.|.:..:|..|.....
 Worm    74 PILDRYVFTVLGKC-WHQSCLRCCDCRAPM--SMTCFSRDGLILCKTDFSRRYSQRCAGCDGKLE 135

  Fly   125 KNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSLTSSSVES 189
            |.|.|.||:.|:|||.||:||.|.|.|..||:..:.:.....|:.|.....|:|    |.:|:..
 Worm   136 KEDLVRRARDKVFHIRCFQCSVCQRLLDTGDQLYIMEGNRFVCQSDFQTATKTS----TPTSIHR 196

  Fly   190 NNNISSSNNNNTNLSNNNHSSELG---SMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTVLNEK 251
            ..:..|..|::....|.:...|:|   ...|.|.::....:...:|  ||        ||.:..|
 Worm   197 PVSNGSECNSDVEEDNVDACDEVGLDDGEGDCGKDNSDDSNSAKRR--GP--------RTTIKAK 251

  Fly   252 QLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKEGRKL 316
            ||.||:..:.|.|:|...::|||...|.|:.|||:|||||:|.|:::        |:|.:.|
 Worm   252 QLETLKNAFAATPKPTRHIREQLAAETGLNMRVIQVWFQNRRSKERR--------MKQLRFG--- 305

  Fly   317 GYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQPPWKALSDFALHADLDSNGAINTHT----PAF 377
            ||.        .|...|.|..:::...|.|.|.||  ..|:.....|..:....|..|    |.|
 Worm   306 GYR--------QSRRPRRDDIVDMFPNDQQFYPPP--PPSNVQFFCDPYTTSPNNPETIQMAPQF 360

  Fly   378 QQLVNQMHGYDLNGMPILPPHPHSHPAQGPP 408
            ......|:         :.|.|::..:..||
 Worm   361 AVPTENMN---------MVPEPYTEQSATPP 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	22/53 (42%)
		LIM2_Isl	116..171	CDD:188760	21/54 (39%)
		HOX	241..297	CDD:197696	25/55 (45%)
lin-11	NP_492696.1	LIM	68..123	CDD:395333	24/57 (42%)
		LIM2_Lhx1_Lhx5	127..182	CDD:188761	21/54 (39%)
		Homeodomain	242..298	CDD:459649	28/65 (43%)