DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tup and lim-7

DIOPT Version :9

Sequence 1:	NP_001286068.1	Gene:	tup / 35147	FlyBaseID:	FBgn0003896	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_491668.1	Gene:	lim-7 / 172236	WormBaseID:	WBGene00002989	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	476	Identity:	168/476 - (35%)
Similarity:	233/476 - (48%)	Gaps:	103/476 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EIGG----------HLAHQLPLHNHNHNQTGLQPSLVMNHHLDLDCHGHDVIKKQRLSHCVGCGG 59
            ||||          :|....|:....|     ||.:.:                     |.||..
Worm    23 EIGGSFWKDEPDTKYLCLDSPVEQRQH-----QPPMAV---------------------CAGCRL 61

  Fly    60 QIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCDKCGNSFS 124
            :|.|:|.|||.|:||:||.||||.:|.:.|||:.|.||::|:|||:.||.|||.|:|.:|...|.
Worm    62 EISDRYFLRVNPNLEFHAQCLKCVQCSRPLDENQTAFVKNGQTYCRDDYRRLFTTRCSRCHGDFD 126

  Fly   125 KNDFVMRA-KTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEK-SSQSSLTSSSV 187
            |.|.|||| ...:||:.||.|.||.::|..|:||.::: .:|||:.|...|:. .:.:|:...|.
Worm   127 KTDLVMRAGPQNVFHLNCFACVACEKRLQTGEEFQIKN-NSLYCRSDCRGLDNPDTSASVPDYSK 190

  Fly   188 ESNNNISSSNNNNTNLS--------------NNNHSSELGSMSDSGSES---GSHKSIRDKRPSG 235
            .:|||.:.:||:::|..              :||.||.|||....|..:   |.|.|     .||
Worm   191 LNNNNNNDNNNSSSNFDEDEWDEERSTLTSLDNNTSSPLGSPKSDGVRTPLFGHHNS-----GSG 250

  Fly   236 PS---------DGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQN 291
            .|         |.:.|||||||||.||..||.||:.|.||||.:||:|||||.||.|||||||||
Worm   251 GSTSSCGKKKKDKQATRVRTVLNENQLKILRDCYSINSRPDATLKERLVEMTGLSARVIRVWFQN 315

  Fly   292 KRCKDKKKTIQM-KLQMQQEKEGRKLGYGAMQGI-PMIASSPVRH-DSPLNLQGLDVQTYQPPWK 353
            |||||||:.||: :.::..|:| ..|....:.|| |::......| |:.|. ..:|:|.: ..|
Worm   316 KRCKDKKRQIQITENRLNSERE-EVLNRVRVNGIGPLMVQPATPHIDNTLG-GPIDIQHF-AQW- 376

  Fly   354 ALSDFALHADLDSNGAINTHTPAF--QQLVNQMHGYDLNGM--PILPPHPHSHPAQGP------P 408
                         ||......|.:  ..:.|....:|::.:  |:.|.......|.||      |
Worm   377 -------------NGTPPPPPPQYGNPMMFNSPSTFDVSVILAPVAPNVTSPSEALGPLGASVFP 428

  Fly   409 H---QHPPPPGGPHNHQNQQP 426
            |   ||.|.....|:..:..|
Worm   429 HFSPQHAPFTATSHDISSPAP 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_001286068.1	LIM1_Isl	54..108	CDD:188752	29/53 (55%)
		LIM2_Isl	116..171	CDD:188760	23/55 (42%)
		HOX	241..297	CDD:197696	42/55 (76%)
lim-7	NP_491668.1	LIM1_Isl	56..110	CDD:188752	29/53 (55%)
		LIM	118..172	CDD:413332	23/54 (43%)
		HOX	267..321	CDD:197696	41/53 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166995
Domainoid	1	1.000	92	1.000	Domainoid score	I4846
eggNOG	1	0.900	-	-		E33208_3BAXJ
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1661
Inparanoid	1	1.050	237	1.000	Inparanoid score	I2137
Isobase	1	0.950	-	0	Normalized mean entropy	S3195
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D403874at33208
OrthoFinder	1	1.000	-	-		FOG0002096
OrthoInspector	1	1.000	-	-		oto20625
orthoMCL	1	0.900	-	-		OOG6_105408
Panther	1	1.100	-	-	LDO	PTHR24204
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5473
SonicParanoid	1	1.000	-	-		X1777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740