Protein Alignment tup and Lhx2

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_001407283.1
• Gene: Lhx2 / 16870
• MGIID: 96785
• Length: 414
• Species: Mus musculus
• Alignment Length: 398
• Identity: 109/398 - (27%)
• Similarity: 175/398 - (43%)
• Gaps: 73/398 - (18%)

  Fly    46 IKKQRLSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYV- 109
            |...|.:.|.||||:|.|:|.| :|.|.:||..||||.||:..|:...|||.:||..|||.||.
Mouse    45 ISSDRAALCAGCGGKISDRYYL-LAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYS 108

  Fly   110 -------RLFGT-KCDKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALY 166
                   |.|.. :|.:|....|.::.||||:..::|:.||.|:.|.:.|..||.|.::|: .:|
Mouse   109 PSLHGPHRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDS-LVY 172

  Fly   167 CKEDHDVLEKSS----------QSSLTSSSVESNNNISSSNNNNTNLSNNN-------------- 207
            |:...:.|.:..          .::..:::...:..:.|:..|...|...|
Mouse   173 CRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGSAGANPLGLPYYNGVGTVQKGRPRKRK 237

  Fly   208 ---HSSELGSMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTVLNEKQLHTLRTCYNANPRPDAL 269
               ..::|.:.:.:.|.:.:.....|:....||..|..|:||.....||.|:::.:..|..|||.
Mouse   238 SPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAK 302

  Fly   270 MKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQEKEG-RKLGYGAMQ-GIPMIASSPV 332
            ..:||.:.|.|:.||::|||||.|.|.::..      ::||..| .|.....:| |.|   |.|.
Mouse   303 DLKQLAQKTGLTKRVLQVWFQNARAKFRRNL------LRQENTGVDKTSDATLQTGTP---SGPA 358

  Fly   333 RHDSPLNLQGLDVQTYQPPWKALSDFALHADLDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPP 397
            ...|..:|......|      .|:|.       ::..:.|.|.....:...:.|::
Mouse   359 SELSNASLSPSSTPT------TLTDL-------TSPTLPTVTSVLTSVPGNLEGHE--------- 401

  Fly   398 HPHSHPAQ 405
             ||| |:|
Mouse   402 -PHS-PSQ 407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	28/53 (53%)
		LIM2_Isl	116..171	CDD:188760	19/54 (35%)
		HOX	241..297	CDD:197696	23/55 (42%)
Lhx2	NP_001407283.1	LIM1_Lhx2	43..106	CDD:188853	30/61 (49%)
		LIM2_Lhx2_Lhx9	119..177	CDD:188763	19/58 (33%)
		COG5576	<255..386	CDD:227863	41/152 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..278		5/19 (26%)
		Homeodomain	275..331	CDD:459649	23/55 (42%)
		Nuclear localization signal. /evidence=ECO:0000255	315..331		9/15 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..383		14/62 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	395..414		6/24 (25%)