Protein Alignment tup and Lhx1

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_032524.1
• Gene: Lhx1 / 16869
• MGIID: 99783
• Length: 406
• Species: Mus musculus
• Alignment Length: 461
• Identity: 141/461 - (30%)
• Similarity: 201/461 - (43%)
• Gaps: 90/461 - (19%)

  Fly    53 HCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCD 117
            ||.||...|.|:::|.|. |..||..|::|.||:..|.|.  ||.|:||.|||.|:.|.|||||.
Mouse     3 HCAGCKRPILDRFLLNVL-DRAWHVKCVQCCECKCNLTEK--CFSREGKLYCKNDFFRCFGTKCA 64

  Fly   118 KCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSL 182
            .|....|.:|.|.||::|:||:.||.|..|.:||..|:|..:.|.....||||:          |
Mouse    65 GCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGEELYIIDENKFVCKEDY----------L 119

  Fly   183 TSSSVESNNNI-SSSNNNNTNLSNNNH--------SSELGSMSD--SGSESGSHKSIRDKRPSGP 236
            ::|||...|:: |::..::.:||.::.        .||..::||  .||.....:::..|| .||
Mouse   120 SNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESANVSDKEGGSNENDDQNLGAKR-RGP 183

  Fly   237 SDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTI 301
                    ||.:..|||.||:..:.|.|:|...::|||.:.|.|:.|||:|||||:|.|:::
Mouse   184 --------RTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERR--- 237

  Fly   302 QMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRH---DSPLNLQGLDVQTYQPPWKALSDFALHAD 363
                 |:|                :.|....||   .||..::.| |...:|           .:
Mouse   238 -----MKQ----------------LSALGARRHAFFRSPRRMRPL-VDRLEP-----------GE 269

  Fly   364 LDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQ 428
            |..||..:.:.....:.......||     ..|..|.|..||.|......|..|        |:.
Mouse   270 LIPNGPFSFYGDYQSEYYGPGGNYD-----FFPQGPPSSQAQTPVDLPFVPSSG--------PSG 321

  Fly   429 QPGGSSLDSGITSHHHPDSTDSYVTYL---ESDDKSKLALTPSSSSSASAGTSISSPP-SGVGAG 489
            .|.| .||..:..||.......:...|   ..|..|.....|....|.||.....||| |.:...
Mouse   322 TPLG-GLDHPLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVN 385

  Fly   490 GGGAVG 495
            ||.:.|
Mouse   386 GGASYG 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	24/53 (45%)
		LIM2_Isl	116..171	CDD:188760	22/54 (41%)
		HOX	241..297	CDD:197696	25/55 (45%)
Lhx1	NP_032524.1	LIM1_Lhx1_Lhx5	4..55	CDD:188753	24/53 (45%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	22/54 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..189		16/69 (23%)
		Homeodomain	181..237	CDD:459649	27/63 (43%)
		dnaA	<263..>382	CDD:455861	32/143 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	294..372		23/91 (25%)