Protein Alignment tup and Lhx5

DIOPT Version :10

• Sequence 1: NP_476775.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_620605.1
• Gene: Lhx5 / 124451
• RGDID: 71079
• Length: 402
• Species: Rattus norvegicus
• Alignment Length: 435
• Identity: 137/435 - (31%)
• Similarity: 205/435 - (47%)
• Gaps: 72/435 - (16%)

  Fly    53 HCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTYCKRDYVRLFGTKCD 117
            ||.||...|.|:::|.|. |..||..|::|.||:..|.|.  ||.|:||.|||.|:.|.|||||.
  Rat     4 HCAGCERPILDRFLLNVL-DRAWHIKCVQCCECKTNLSEK--CFSREGKLYCKNDFFRRFGTKCA 65

  Fly   118 KCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSL 182
            .|....|.:|.|.:|::|:||:.||.|..|.:||..|:|..:.|.....||:|:          |
  Rat    66 GCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDY----------L 120

  Fly   183 TSSSVE--SNNNISSSNN------------NNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKRP 233
            :|||::  |.|::||..:            ::...::|:.||:..:.::...|..|....|
  Rat   121 SSSSLKEGSLNSVSSCTDRSLSPDLQDPLQDDPKETDNSTSSDKETANNENEEQNSGTKRR---- 181

  Fly   234 SGPSDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKK 298
             ||        ||.:..|||.||:..:.|.|:|...::|||.:.|.|:.|||:|||||:|.|:::
  Rat   182 -GP--------RTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERR 237

  Fly   299 KTIQMKLQMQQE------KEGRKLGYGAMQGIPMIASSPVR----HDSPLNLQG--LDVQTYQPP 351
            ......|..::.      :..|.|| |.:....|:.|:|..    :.|.....|  .|...:.||
  Rat   238 MKQLSALGARRHAFFRSPRRMRPLG-GRLDESEMLGSTPYTYYGDYQSDYYAPGGNYDFFAHGPP 301

  Fly   352 WKALSDFALHAD---LDSNGAINTHTPAFQQLVNQMHGYDLNGMPILPPHPHS-HPAQG-PPHQH 411
            .:|.|.    ||   |.::|..:|...|.:..:...||.|......:..||.: .|..| |...|
  Rat   302 SQAQSP----ADSSFLAASGPGSTPLGALEPPLAGPHGADNPRFTDMISHPDTPSPEPGLPGALH 362

  Fly   412 PPP----PGGPHNHQNQQPNQQPGGSSLDSGITSHHHPDSTDSYV 452
            |.|    .|||      .|.....|:|..||..||.:|:..::.|
  Rat   363 PMPGEVFSGGP------SPPFPMSGTSGYSGPLSHPNPELNEAAV 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_476775.1	LIM1_Isl	54..108	CDD:188752	24/53 (45%)
		LIM2_Isl	116..171	CDD:188760	20/54 (37%)
		HOX	241..297	CDD:197696	25/55 (45%)
Lhx5	NP_620605.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	24/53 (45%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	20/54 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..186		14/74 (19%)
		Homeodomain	181..237	CDD:459649	28/68 (41%)
		PHA03378	<247..>392	CDD:223065	40/155 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..402		33/114 (29%)