Protein Alignment tup and Isl2

DIOPT Version :9

• Sequence 1: NP_001286068.1
• Gene: tup / 35147
• FlyBaseID: FBgn0003896
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: XP_006510819.1
• Gene: Isl2 / 104360
• MGIID: 109156
• Length: 370
• Species: Mus musculus
• Alignment Length: 373
• Identity: 201/373 - (53%)
• Similarity: 244/373 - (65%)
• Gaps: 49/373 - (13%)

  Fly    45 VIKKQR------LSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFVRDGKTY 103
            |:::||      .:.|||||.|||||:||||:||||||||||||.||.|:|||:|||||||||||
Mouse    23 VLQRQRNGEKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTY 87

  Fly   104 CKRDYVRLFGTKCDKCGNSFSKNDFVMRAKTKIFHIECFRCSACARQLLPGDEFALRDAGALYCK 168
            ||||||||||.||.:|...||.:|.||||:..::||||||||.|:|||||||||:||: ..|.|:
Mouse    88 CKRDYVRLFGIKCAQCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLRE-HELLCR 151

  Fly   169 EDHD-VLEKSSQSSLTSSSVESNNNISSSNNNNTNLSNNNHSSELGSMSDSGSESGSHKSIRDKR 232
            .||. :||:::..|..|......             :...|..:.||.......:..||...
Mouse   152 ADHGLLLERAAAGSPRSPGPLPG-------------ARGLHLPDAGSGRQPSLRTHVHKQAE--- 200

  Fly   233 PSGPSDGKPTRVRTVLNEKQLHTLRTCYNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDK 297
                   |.|||||||||||||||||||.|||||||||||||||||.||||||||||||||||||
Mouse   201 -------KTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDK 258

  Fly   298 KKTIQMKLQMQQEKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQPPWKALSDFALHA 362
            ||:|.|| |:||::...|.....:.|.|::|.||:||::.:....::||||||||||||:|||.:
Mouse   259 KKSILMK-QLQQQQHSDKASLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQS 322

  Fly   363 DLDSNGAINTHTPAFQQLVN--------QMHGYDLNGMPI-LPPHPHS 401
            |||.        |||||||:        ...|.|:..:.. ||..|:|
Mouse   323 DLDQ--------PAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNS 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tup	NP_001286068.1	LIM1_Isl	54..108	CDD:188752	46/53 (87%)
		LIM2_Isl	116..171	CDD:188760	31/54 (57%)
		HOX	241..297	CDD:197696	52/55 (95%)
Isl2	XP_006510819.1	LIM1_Isl	38..92	CDD:188752	46/53 (87%)
		LIM2_Isl2	100..154	CDD:188855	31/54 (57%)
		HOX	202..258	CDD:197696	52/55 (95%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849744
Domainoid	1	1.000	126	1.000	Domainoid score	I5395
eggNOG	1	0.900	-	-		E33208_3BAXJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1918
Isobase	1	0.950	-	0	Normalized mean entropy	S3195
OMA	1	1.010	-	-		QHG45829
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002096
OrthoInspector	1	1.000	-	-		otm44078
orthoMCL	1	0.900	-	-		OOG6_105408
Panther	1	1.100	-	-	LDO	PTHR24204
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5473
SonicParanoid	1	1.000	-	-		X1777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740